A5044685480- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Heat shock proteins research
- interferon and immune responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Circular RNAs in diseases
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Genital Health and Disease
- Histone Deacetylase Inhibitors Research
- Cervical Cancer and HPV Research
- Inflammatory mediators and NSAID effects
- Glioma Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
Northwest A&F University
2015-2025
Hubei Cancer Hospital
2025
Sun Yat-sen Memorial Hospital
2023-2024
Sun Yat-sen University
2023-2024
Chengdu Third People's Hospital
2024
Southwest Jiaotong University
2024
Affiliated Hospital of Guizhou Medical University
2024
Guiyang Medical University
2024
Children's Hospital of Chongqing Medical University
2010-2023
Chongqing Medical University
2010-2023
MicroRNAs (miRNAs) are noncoding RNA molecules of 21-24 nt that regulate the expression target genes in a post-transcriptional manner. Evidence indicates miRNAs play essential roles embryogenesis, cell differentiation and pathogenesis human diseases. This study describes comparison between miRNA profile systemic lupus erythematosus (SLE) patients controls to develop further understanding SLE. Peripheral blood mononuclear cells were isolated from samples 23 SLE patients, 10 idiopathic...
Cancer is a common comorbidity of diabetic patients; however, little known about the effects that antidiabetic drugs have on tumors. We discovered classes used in type 2 diabetes mellitus, hypoglycemic dipeptidyl peptidase-4 inhibitors (DPP-4i) saxagliptin and sitagliptin, as well antineuropathic α-lipoic acid (ALA), do not increase tumor incidence but risk metastasis existing Specifically, these induce prolonged activation nuclear factor E2-related (NRF2)-mediated antioxidant response...
// Yi Huang 1,2,* , Chunling Ma 1,3,4,* Qunyuan Zhang 5 Jian Ye 1 Fang Wang 1,6 Yanping 7 Pamela Hunborg Mark A. Varvares 8 Daniel F. Hoft Eddy C. Hsueh and Guangyong Peng Department of Internal Medicine, Saint Louis University School Louis, MO, USA 2 Center for Clinical Molecular Children’s Hospital Chongqing Medical University, Chongqing, P. R. China 3 Laboratory Women Health Care Linyi City, Linyi, 4 Biology Experimental Center, Shandong College, Genetics, Washington Medicine in St....
Dysregulated miR-7 and aberrant NF-κB activation were reported in various human cancers. However, the expression profile, clinical relevance dysregulated mechanism of RelA/p65 gastric cancers (GC) metastasis remain largely unknown. This study is to investigate GC explore potential therapeutic effect distant metastasis.TCGA STAD NCBI GEO database used profile relevance. Lentivirus-mediated gene delivery was applied GC. Real-time PCR, FACS, IHC, IF, reporter assay, IP, pre-miRNA-7 processing...
Objectives To investigate sex difference in global gastric cancer incidence by year, age and socioeconomical status. Design An international comparative study. Setting We obtained the national sex-specific of caner year from Global Burden Disease Study 2017. The human development index (HDI) 2017 as an indicator status was extracted Human Development Report. Main outcome measures Sex-specific compared at level. Linear regression analyses were performed to explore socioeconomic-associated...
We aimed to develop and validate a comprehensive nomogram containing pre-treatment plasma HSP90AA1 predict the risk of breast cancer onset metastasis.We assessed expression HSP90s in patients using an online database. To verify results, 677 diagnosed with 146 benign disease between 2014 2019 were selected from our hospital divided into metastasis cohorts. focused on elucidate risks cohorts.Expression levels HSP90AA1, HSP90AA2, HSP90AB1, HSP90B1, TRAP1 linked progression. Survival analysis...
Abstract Understanding the role of different subtypes tumor-infiltrating lymphocytes (TIL) in immunosuppressive tumor microenvironment is essential for improving cancer treatment. Enriched γδ1 T-cell populations TILs suppress responses and dendritic cell maturation breast cancer, where their presence correlated negatively with clinical outcomes. However, mechanism(s) that explain increase this class regulatory T cells (γδ Treg) patients have yet to be elucidated. In study, we show IP-10...
Whole body heat stress had detrimental effect on male reproductive function. It's known that the nuclear factor erythroid 2-related 2 (Nrf2) activates expression of cytoprotective genes to enable cell adaptation protect against oxidative stress. However, it's still unclear about exactly effects Nrf2 testis. Here, we investigate protective whole stress-induced damage in mouse Male mice were exposed elevated ambient temperature (42°C) daily for h. During period twelve consecutive days,...
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with an estimated 1.8 million new cases worldwide and associated high mortality rates 881 000 CRC-related deaths in 2018. Screening programs therapies have only marginally improved survival CRC patients. Immune-related genes (IRGs) attracted attention recent years as therapeutic targets. The aim this study was to identify immune-related prognostic signature for CRC. To end, we combined gene expression clinical data from...
The role of brain immune compartments in glioma evolution remains elusive. We profile cells microenvironment and the matched peripheral blood from 11 patients. Glioblastoma exhibits specific infiltration blood-originated monocytes expressing epidermal growth factor receptor (EGFR) ligands EREG AREG, coined as tumor-associated (TAMo). TAMo is mutually exclusive with EGFR alterations (p = 0.019), while co-occurring mesenchymal subtype 4.7 × 10−7) marking worse prognosis 0.004 0.032 two...
microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies reported that miR-223 may serve a suppressor in number of cancer types, however, knowledge its targets non-small cell lung (NSCLC) remains limited. In the current study, was found inhibit proliferation vitro CCK-8 assay, growth curves and an anchorage-independent assay Lewis carcinoma (LLC) line. transfection LLC cells observed significantly...
Abstract This study aimed to evaluate the efficacy and safety of venetoclax plus azacitidine donor lymphocyte infusion (DLI) in treating patients with relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-six AML who allo-HSCT were enrolled treated DLI. Complete remission incomplete recovery (CRi), partial (PR), objective rate (ORR) assessed, then event-free survival (EFS) overall (OS) evaluated. Besides, adverse events documented....
ABSTRACT Deoxynivalenol (DON), a mycotoxin primarily produced by Fusarium species, is commonly found in cereal grains and poses risks to human animal health, as well global grain trade. This study demonstrates that methyl jasmonate (MeJA), natural plant hormone, inhibits the growth conidiation of graminearum . Importantly, MeJA significantly reduces DON production suppressing TRI gene expression toxisome formation. To explore molecular mechanism, we identified MeJA-tolerant mutants,...
This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify optimal LND range for improved survival. By analyzing data from Surveillance, Epidemiology, End Results (SEER) database conducted USA NUWA China, we found that who underwent SEER cohort exhibited significantly long-term survival rates compared those did not undergo LND, while difference was statistically significant cohort. Cox...
Abstract Background Human olfactomedin 4 (OLFM4) gene is a secreted glycoprotein more commonly known as the anti-apoptotic molecule GW112. OLFM4 found to be frequently up-regulated in many types of human tumors including gastric cancer and it was believed play significant role progression cancer. Although function has been indicated studies, recent evidence strongly suggests cell or tissue type-dependent growth apoptosis. The aim this study examine cancer-specific expression apoptosis...
Breast cancer is a heterogeneous group of diseases. The polarization CD4+ T helper (Th) lymphocytes (mainly Th1 and Th2) may differ in breast cancers with different outcomes, but this has not been fully validated.This study bioinformatic analysis, which differentially expressed genes (DEGs) were identified patients low high Th1/Th2 ratios. And then, DEG functions, hub independent predictors determined.Low ratio was associated poor outcome Luminal A basal-like (p < 0.05). GSEA KEGG analysis...
Cancer-associated fibroblasts (CAFs) aggravate gastric cancer (GC) development.Combined with bioinformatics analysis and literature review, miR-223-3p had high expression in microvesicles (MVs) derived from GC CAFs, it could modulate SORBS1. SORBS1 mRNA levels were assessed by qRT-PCR. The of CAFs markers, MVs epithelial-mesenchymal transition (EMT)-associated proteins, protein western blot. isolated observed transmission electron microscopy. Combined immunofluorescence co-culture...
Porcine epidemic diarrhea (PED) caused by virulent strains of porcine virus (PEDV) is a highly contagious enteric disease swine characterized severe enteritis, vomiting, and watery diarrhea.This study investigates the subcellular localization function PEDV M protein through examination its effects on cell growth, cycle progression, interleukin 8 (IL-8) expression.Our results revealed that localized throughout cytoplasm.The altered intestinal epithelial line (IEC) growth induced arrest at...
// Yi Huang 1, * , Meihua Yang 2, Huajian Hu 3, Xiaodong Zhao 1 Liming Bao 4 Daochao 5 Lihua Song 6 Li Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital Medical University, Ministry Education Development Disorders, China International Science Technology Cooperation Base Critical 400014, PR 2 Department Neurosurgery, Xinqiao Third Military 400038, 3 Gastroenterology, Pathology, Dartmouth-Hitchcock Center, Geisel School Medicine at Dartmouth College, Lebanon, NH...