A5100442310- Nanoplatforms for cancer theranostics
- Photochromic and Fluorescence Chemistry
- Luminescence and Fluorescent Materials
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Microtubule and mitosis dynamics
- Pancreatic function and diabetes
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Tryptophan and brain disorders
- Drug Transport and Resistance Mechanisms
- Industrial Technology and Control Systems
- Advanced Drug Delivery Systems
- Abdominal vascular conditions and treatments
- Photodynamic Therapy Research Studies
- Anesthesia and Pain Management
- Advanced Nanomaterials in Catalysis
- Ubiquitin and proteasome pathways
- Neurotransmitter Receptor Influence on Behavior
University of Hong Kong
2013-2025
Chinese University of Hong Kong
2020-2025
Hebei Medical University
2002-2025
Second Hospital of Hebei Medical University
2008-2025
Henan Provincial Eye Hospital
2025
Henan Provincial People's Hospital
2025
University of Science and Technology of China
2009-2024
National University of Defense Technology
2009-2024
Wuhan University
2006-2024
University of Science and Technology Beijing
2024
Therapeutic nanoreactors have been proposed to treat cancers through in situ transformation of low-toxicity prodrugs into toxic therapeutics the body. However, vivo applications are limited by low tissue-specificity and different tissue distributions between sequentially injected prodrugs. Herein, we construct a block copolymer prodrug-based polymersome nanoreactor that can achieve novel orchestrated oxidation/chemotherapy cancer via specific activation at tumor sites. The copolymers...
Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness can lead to systemic side effects. Photodynamic therapy (PDT) a photoresponsive cancer based on photosensitizers generate reactive oxygen species (ROS) eradicate tumor cells. Our previous study showed that exosomes derived from human γδ-T cells (γδ-T exosomes) could control Epstein–Barr virus-associated tumors. Here, we combined PDT for targeted photoimmunotherapy by...
Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially during G2/M, it remained unknown how PR-Set7 itself was regulated. In this study, we discovered mechanisms that govern dynamic regulation of mitosis, and perturbation these pathways results defective mitotic progression. First, found is phosphorylated at Ser 29 (S29) specifically by cyclin-dependent kinase 1 (cdk1)/cyclinB complex,...
High-efficiency upconverted light would be a desirable stimulus for triggered drug delivery. Here we present general strategy to achieve photoreactions based on triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET). We designed PLA-PEG micellar nanoparticles containing in their cores hydrophobic photosensitizer annihilator molecules which, when stimulated with green light, undergo TTA-UC. The was then transferred by FRET photocleavable group (DEACM),...
Background microRNAs (miRNAs) are a class of small, non-coding endogenous RNAs that post-transcriptionally regulate some protein-coding genes. miRNAs play an important role in many cardiac pathophysiological processes, including myocardial infarction, hypertrophy, and heart failure. miR-499, specifically expressed skeletal muscle cells, is differentially regulated functions development. However, the function miR-499 mature poorly understood.Results We report cardiac-abundant could protect...
Choroidal neovascularization (CNV) is the major cause of vision loss in wet age-related macular degeneration (AMD). Current therapies require repeated intravitreal injections, which are painful and can infection, bleeding, retinal detachment. Here we develop nanoparticles (NP-[CPP]) that be administered intravenously allow local drug delivery to diseased choroid via light-triggered targeting. NP-[CPP] formed by PEG-PLA chains modified with a cell penetrating peptide (CPP). Attachment DEACM...
Folic acid (FA) has been extensively exploited to facilitate targeted delivery of nanomedicines by recognizing the folate receptor-α (FR-α) overexpressed in many human cancers. Unfortunately, none have approved for clinical use yet. Here we reveal that FA functionalization induces heavy natural IgM absorption on liposomal surface, depriving receptor recognition and accelerating complement activation vivo. does not enhance distribution liposomes FR-α-overexpressed tumors comparison plain...
The low utilization efficiency of pesticides exerts an adverse impact on the environment and human health. Polymer-related controlled-release nanosized pesticide systems provide a promising efficient way to overcome problem. In this work, biodegradable light-responsive amphiphilic polymer was synthesized via 1,1,3,3-tetramethylguanidine-promoted polyesterification under mild conditions (low temperature, no vacuum, inert gas protection). We used fabricate light-triggered system. herbicide,...
Abstract Ferroptosis as programmed cell death received considerable attention in cancer research. Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because PDT promotes glutathione (GSH) deletion, peroxidase 4 (GPX4) degradation, and lipid peroxide accumulation. However, PDT‐induced may be potentially prevented by suppressor protein 1 (FSP1). To address this limitation, herein, a novel strategy is developed to trigger FSP1 inhibition. For enhancement of strategy,...
Abstract Nowadays, cancer has become the leading cause of death worldwide, driving need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) been widely applied as an antitumor modality, owing its minimal invasiveness, localized tumor damage, and high safety profile. However, efficacy is limited by poor stability photosensitizers, inadequate accumulation, a complex microenvironment. To overcome these challenges, extensive endeavors have made explore co‐assembly...
Expression of antioxidant and phase 2 xenobiotic metabolizing enzyme genes is regulated through cis-acting sequences known as response elements. Transcriptional activation the elements involves members CNC (Cap 'n' Collar) family basic leucine zipper proteins including Nrf1 Nrf2. Nrf2 activity by Keap1-mediated compartmentalization in cell. Given structural similarities between Nrf2, we sought to investigate whether similarly also resides normally cytoplasm cells. Cytoplasmic localization...
BackgroundMiR-499 is a cardiac-abundant miRNA. However, the biological functions of miR-499 in differentiated cardiomyocytes or cardiomyocyte differentiation process not very clear. Sox6 believed to be one its targets, and also play role cardiac differentiation. Therefore, our aim was investigate association between during Methodology/Principal FindingsUsing well-established vitro system, mouse P19CL6 cells, we found that highly expressed late stage In cells stably transfected with (P-499...
ES cells proliferate with very short gap phases yet maintain their capacity to differentiate. It had been thought that the levels of cyclins and other substrates ubiquitin ligase APC/C remain nearly constant Cdk activity remains constitutively high in mouse cells. Here we demonstrate (anaphase-promoting complex/cyclosome) enzyme is active but attenuated by Emi1 (early mitotic inhibitor-1) protein. Despite presence during G1 phase, chromatin can be effectively licensed for DNA replication...
We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), light-triggered phase transition of their lipid bilayers consequent release payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) injected subcutaneously rat footpad. Irradiation an 808 nm...
Islet 1 (ISL1), a LIM-homeodomain transcription factor is essential for promoting pancreatic islets proliferation and maintaining endocrine cells survival in embryonic postnatal islets. However, how ISL1 exerts the role adult is, to date, not clear.Our results show that expression was up-regulated at mRNA level both cultured undergoing glucose oxidase stimulation as well type 2 diabetes mouse models. The knockdown of increased apoptosis HIT-T15 islet cells. Using primary cell models, we...
The targeted delivery of therapeutic cargos using noninvasive stimuli has the potential to improve efficacy and reduce off-target effects (toxicity). Here, we demonstrate a targeting mechanism that uses thermoresponsive copolymer mask peptide ligand binds widely distributed receptor (integrin β1) on surface silica core-gold shell nanoparticles. nanoparticles convert NIR light into heat, which causes collapse, exposing peptide, allowing cell binding. use could allow plasmonic deep within...