A5008544946- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Retinoids in leukemia and cellular processes
- Porphyrin and Phthalocyanine Chemistry
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Cancer Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
- Synthesis and Biological Evaluation
- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
Pfizer (United States)
2007-2025
Ningxia Medical University General Hospital
2021-2025
Ningxia Medical University
2021-2025
Zhengzhou University
2015-2024
Yantai Academy of Agricultural Sciences
2023-2024
Institute of Plant Protection
2024
Yantai University
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2019-2024
Jinan University
2024
Kunming Medical University
2024
A series of substituted 2-(aminopyridyl)- and 2-(aminopyrimidinyl)thiazole-5-carboxamides was identified as potent Src/Abl kinase inhibitors with excellent antiproliferative activity against hematological solid tumor cell lines. Compound 13 orally active in a K562 xenograft model chronic myelogenous leukemia (CML), demonstrating complete regressions low toxicity at multiple dose levels. On the basis its robust vivo favorable pharmacokinetic profile, selected for additional characterization...
Abstract Therapeutically targeting aberrant intracellular kinase signaling is attractive from a biological perspective but drug development often hindered by toxicities and inadequate efficacy. Predicting behaviors using cellular animal models confounded redundant activities, lack of unique substrates, cell-specific networks. Cyclin-dependent (CDK) drugs exemplify this phenomenon because they are reported to target common processes yet have distinct clinical activities. Tumor cell studies...
Checkpoints are present in all phases of the cell cycle and regarded as gatekeepers maintaining integrity genome. Many conventional agents used to treat cancer impart damage genome activate checkpoints. tumors defective tumor suppressor p53 therefore lack a functional G(1) checkpoint. In these tumors, however, S-G(2) checkpoints remain intact and, response DNA damage, arrest progression allowing time for repair. Checkpoint kinase 1 (Chk1) is key element pathway plays crucial role...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation primary resistant to EGFR-TKIs such gefitinib. Curcumin has been known a potential therapeutic agent for several major human cancers. In this study, we investigated the effect of curcumin on reversal gefitinib resistance cells well their molecular bases. H157 (wild-type KARS...
Background microRNAs (miRNAs) are a class of small, non-coding endogenous RNAs that post-transcriptionally regulate some protein-coding genes. miRNAs play an important role in many cardiac pathophysiological processes, including myocardial infarction, hypertrophy, and heart failure. miR-499, specifically expressed skeletal muscle cells, is differentially regulated functions development. However, the function miR-499 mature poorly understood.Results We report cardiac-abundant could protect...
Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles mechanisms of hydroxychloroquine (HCQ) in combination with chemotherapy lung treatment.The effects combined treatment on non-small cell (NSCLC) were using viability assays animal models. The influence HCQ lysosomal pH was evaluated by sensors confocal microscopy. tumour microenvironment analysed flow cytometry.HCQ elevates cells to...
Abstract Esophageal squamous carcinoma (ESCC) may be developed through a progressive sequence from mild to severe dysplasia, in situ, and finally, invasive carcinoma. Chemoprevention can block or weaken the influence of development. Recent study has shown luteolin, bioflavonoid, possesses anti-inflammatory, antioxidant, anti-proliferative effects, it might have preventive effect this progress. In study, we focused on luteolin cell cycle regulation human Squamous Carcinoma Cell Line EC1...
Highlights•Atirmociclib (PF-07220060) is a next-generation CDK4 selective inhibitor•Impact reduction on neutrophils was in proportion to increase selectivity•Greater target coverage results deeper anti-tumor responses•Combinatorial agents further atirmociclib efficacySummaryCDK4/6 inhibitors have revolutionized treatment of hormone receptor positive (HR+), HER2 non-amplified (HER2−) breast cancer. Yet, all "dual" CDK4/6 show common dose-limiting hematologic toxicities, foremost neutropenia....
Mammalian Chk1 and Chk2 are two Ser/Thr effector kinases that play critical roles in DNA damage-activated cell cycle checkpoint signaling pathways downstream of ataxia telangiectasia-mutated telangiectasia-related. Endogenous substrates have been identified for human hCds1/Chk2 Chk1; however, the sequences surrounding substrate residues appear unrelated, consensus motifs remain unknown. We utilized peptide library analyses to develop specific, highly preferred Chk1. The optimal similar both...
Recent studies have revealed the scientific basis for use of intravenous (i.v.) vitamin C or ascorbic acid (ascorbate) in treating cancers, and raised possibility using i.v. ascorbate as a prooxidant anticancer therapy. Through production H2O2, pharmacologic can induce some cancer cell death vitro inhibit number types tumor growth animal models. However, mechanism triggered by is not well understood. In this study, we investigated cytotoxicity pharmacological concentrations to human prostate...
Sepsis-induced cardiac apoptosis is one of the major pathogenic factors in myocardial dysfunction. As it enhances numerous proinflammatory factors, lipopolysaccharide (LPS) considered principal mediator this pathological process. However, detailed mechanisms involved are unclear. In study, we attempted to explore LPS-induced cardiomyocyte apoptosis. We found that LPS stimulation inhibited microRNA (miR)-499 expression and thereby upregulated SOX6 PDCD4 neonatal rat cardiomyocytes....
An ascorbate-mediated production of oxidative stress has been shown to retard tumor growth. Subsequent glycolysis inhibition suggested. Here, we further define the mechanisms relevant this observation. Ascorbate was cytotoxic human neuroblastoma cells through H2O2, which led ATP depletion, inhibited GAPDH, and non-apoptotic non-autophagic cell death. The mechanism cytotoxicity is different when PARP-dependent DNA repair machinery active or inhibited. Ascorbate-generated H2O2 damaged DNA,...
Islet-1 (ISL1) belongs to the LIM homeodomain transcription factor family, which is specifically expressed in certain tissue types only. Previously, we reported that ISL1 aberrantly overexpressed gastric cancer (GC). However, its role GC not clear. Here, report upregulated only human carcinoma tissues but also some cell lines. Upregulated expression enhanced xenografted development, while knockdown inhibited growth nude mice. overexpression promoted proliferation, colony formation, and soft...
// Ping Chen 1, 2 , Jing-Yang Zhang Bei-Bei Sha Yan-Er Ma Tao Hu Yang-Cheng Hao Sun 3 Jian-Xiang Shi Zi-Ming Dong Pei Li 1 Cancer Chemoprevention Collaborative Innovation Center in Henan Province, Zhengzhou University, Zhengzhou, Henan, 450001, China Department of Pathophysiology, College Basic Medical Sciences, Public Health, Key Laboratory for Tumor Epidemiology, Affiliated Hospital, Correspondence to: Li, email: lipeifreemai@zzu.edu.cn Dong, Dongzm@zzu.edu.cn Shi, jianxiangshi@zzu.edu.cn...
BACKGROUND:Berberine, a natural isoquinoline alkaloid derived from Berberis genus plants, has been reported to have anti-cancer effects. While cell behavior can be modulated by long non-coding RNAs (lncRNAs), the contributions of lncRNAs in progression and berberine effects on colorectal cancer are largely unknown. Therefore, present study investigated involvement regulatory function lncRNA susceptibility candidate 2 (CASC2) during treatment human using berberine. MATERIAL AND...
The reduction of dust pollution in coal mines is great importance both for protection the environment and occupational safety health mine workers. from anthracite has been a challenge due to its inherent hydrophobicity high metamorphism. As result, surfactants are commonly added water improve wettability coal, thereby improving efficiency spray system. To clarify microscopic perspective effect different on anthracite, models anthracite-surfactant-water system were established, adsorption...
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. interaction between these monomer units can be modified by the action small molecules in binding interface their C-terminal heterodimerization (PasB) domains. Taking advantage presence several cysteine residues located allosteric cavity PasB domain, we applied cysteine-based reactomics "hotspot identification" strategy locate...
Recently, chloroquine (CQ) has been widely used to improve the efficacy of different chemotherapy drugs treat tumors. However, effects single treatment CQ on liver cancer have not investigated. In present study, we examined growth and viability cells in vitro vivo, revealed that triggered G0/G1 cell cycle arrest, induced DNA damage apoptosis a dose- time-dependent manner cells. Moreover, administration tumor-bearing mice suppressed tumor an orthotopic xenograft model cancer. These findings...
Embryonic stem cells (ESCs) and induced pluripotent (iPSCs) have extensive self-renewal capacity the potential to differentiate into all tissue-specific cell lineages, including corneal endothelial (CECs). They are a promising prospect for future of regenerative medicine. The method derivation CECs from ESCs iPSCs, however, remains be elucidated. In this study, mouse iPSCs were using CEC embryonic development events as guide. All-trans retinoic acid (RA) treatment during embryoid body (EB)...
Accumulating evidence demonstrated that alteronol, a novel compound has similar structure with paclitaxel, exerts anticancer effects against diversified tumors. However, whether alteronol induces autophagy and the relationship between its in melanoma remains elusive. In this study, we show not only anti-proliferation activity apoptosis but also A375 UACC62 cells. addition, inhibits cells invasion migration by preventing epithelial-mesenchymal transition (EMT). Blocking enhances...
Abstract The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1) plays a role in the progression of various tumors, emerging as potential therapeutic target. This study aimed to determine target hepatocellular carcinoma (HCC). We detected expression tumor and adjacent tissues patients with HCC using immunohistochemical staining. evaluated effect inhibitor ML-323 on cell proliferation cycle CCK-8 cell-counting kit plate cloning assays, propidium iodide, respectively. Apoptosis was by...
Abstract Cancer cells are addicted to glutamine. However, cancer often suffer from glutamine starvation, which largely results the fast growth of and insufficient vascularization in interior tissues. Herein, based on clinical samples, patient‐derived (PDCs), cell lines, it is found that liver display stem‐like characteristics upon shortage due maintaining stemness tumor initiating (TICs) even promoting transformation non‐TICs into by starvation. Increased expression synthetase (GS) essential...