A5100636634- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Liver Diseases and Immunity
- Radiopharmaceutical Chemistry and Applications
- Drug-Induced Hepatotoxicity and Protection
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Chronic Myeloid Leukemia Treatments
- Genomics, phytochemicals, and oxidative stress
Shanghai Tenth People's Hospital
2014-2025
Tongji University
2014-2025
Shanghai Ninth People's Hospital
2013-2025
Shanghai Jiao Tong University
2013-2025
Shenzhen Second People's Hospital
2021-2025
Xinjiang Medical University
2024
Fujian Medical University
2016-2024
University of Manchester
2024
Zhejiang Sci-Tech University
2015-2024
Fujian Provincial Cancer Hospital
2016-2024
Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability excise all tumor tissue (if operable), a lack blood-brain barrier (BBB) penetration chemotherapies/targeted agents, and intrinsic radio-/chemo-resistance. Ataxia-telangiectasia mutated (ATM) protein orchestrates cellular DNA damage response (DDR) cytotoxic double-strand breaks induced by ionizing radiation (IR). ATM genetic ablation pharmacological inhibition results in...
Abstract The aim of this study was to investigate the effect quercetin on hepatic fibrosis, a characteristic response acute or chronic liver injury. Mice were randomized bile duct ligation (BDL) carbon tetrachloride (CCl 4 ) cirrhosis models. Quercetin (100 mg/kg 200 daily) administered by gavage for 2 weeks. Liver tissue and blood samples collected histological molecular analysis. results our experiments showed that reduced BDL CCl inhibited extracellular matrix formation, regulated...
Abstract Purpose: Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing T790M resistance mutations. To treat metastatic brain disease, blood–brain barrier (BBB) permeability considered desirable for increasing clinical efficacy. Experimental Design: We examined the level penetration 16 irreversible reversible EGFR-TKIs using multiple in vitro vivo BBB preclinical models. Results: In osimertinib was weakest substrate human efflux transporters...
Hepatocellular carcinoma (HCC) is a common primary malignant tumor which usually progresses to an advanced stage because of late diagnosis. Sorafenib (Sora) first line medicine for HCC; however, it has been faced with enormous resistance. Simvastatin (Sim) cholesterol-lowering drug and reported inhibit growth. The present study aims determine whether Sora Sim co-treatment can improve resistance in HCC.The HCC cell LM3 established Sora-resistant (LM3-SR) were used the relationship between...
Abstract Objective Hepatocellular carcinima is one of the most common tumors in clinic and also leading causes death from cancer worldwide. Quercetin shows significant effects on blocking development various cancers. Methods We used human hepatocellular carcinoma LM3 nude mice tumor model to assess quercetin clarify its mechanism action. collected cell line treated with different doses at time periods determined vital indexes. The liver tissues were for western boltting (WB), Hematoxylin...
Serious illness conversations (SICs) between oncology clinicians and patients are associated with improved quality of life may reduce aggressive end-of-life care. However, most cancer die without a documented SIC.To test the impact behavioral nudges to prompt SICs on SIC rate outcomes among at high risk death within 180 days (high-risk patients) as identified by machine learning algorithm.This prespecified 40-week analysis stepped-wedge randomized clinical trial conducted June 17, 2019,...
Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting and atherosclerosis activated platelets CD36-dependent manner. now show mitogen-activated protein kinase c-Jun N-terminal (JNK)2 its upstream activator MKK4 were phosphorylated exposed oxLDL. Using apoE(-/-) mice as model hyperlipidemia, we JNK was constitutively Inhibition src activity reduced...
Background: Hepatic ischemia reperfusion (IR) is an important issue in complex liver resection and transplantation. The aim of the present study was to determine protective effect astaxanthin (ASX), antioxidant, on hepatic IR injury via reactive oxygen species/mitogen-activated protein kinase (ROS/MAPK) pathway. Methods: Mice were randomized into a sham, IR, ASX or + group. mice received at different doses (30 mg/kg 60 mg/kg) for 14 days. Serum tissue samples 2 h, 8 h 24 after abdominal...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation primary resistant to EGFR-TKIs such gefitinib. Curcumin has been known a potential therapeutic agent for several major human cancers. In this study, we investigated the effect of curcumin on reversal gefitinib resistance cells well their molecular bases. H157 (wild-type KARS...
Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated an increased risk of mortality, cancer progression, resistance to therapy. However, the effect genistein on HIF-1α hepatocellular carcinoma (HCC) still unclear. Cell viability, apoptosis rate, lactate production, glucose uptake were measured HCC cell lines incubation. Lentivirus-expressed transporter...
In Caenorhabditis elegans and Drosophila, removing germline stem cells increases lifespan. C. elegans, this lifespan extension requires DAF-16, a FOXO transcription factor, DAF-12, nuclear hormone receptor. To better understand the regulatory relationships between DAF-16 we used microarray analysis to identify downstream genes. We found that these two factors influence expression of distinct but overlapping sets genes in response loss germline. addition, identified several new are required...
Recent reports suggest that an increasing number of patients with lung cancer, especially those activating mutations the epidermal growth factor receptor (EGFR), also present brain metastases and leptomeningeal metastases. These have poor prognosis as there are no approved drugs for these indications. Available agents efficacy even at well above their standard dose. Herein, we report discovery (4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl...
// Weiqi Dai 1,* , Fan Wang Jie Lu Yujing Xia 1 Lei He Kan Chen Jingjing Li Sainan Tong Liu Yuanyuan Zheng Jianrong 1,2 Wenxia Yuqing Zhou 1,3 Qin Yin Huerxidan Abudumijiti Rongxia Rong Zhang Zhu Jing Yang Chengfen Huawei Yingqun Ling Xu 4 and Chuanyong Guo Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School Medicine, Shanghai, China 2 The First Clinical Medical College Nanjing University, Nanjing, 3 Affiliated Hospital Soochow Suzhou, Tongren Jiaotong...
Non-alcoholic fatty liver disease (NAFLD) is considered to be one of the most common chronic diseases across worldwide. Astaxanthin (Ax) a carotenoid, and beneficial effects astaxanthin, including anti-oxidative, anti-inflammatory, anti-tumour activity, have been identified. The present study aimed elucidate protective effect astaxanthin against NAFLD its underlying mechanism.Mice were fed either high fat or chow diet, with without for up 12 weeks. L02 cells treated free acids combined...
Liver fibrosis is a common pathway leading to cirrhosis and worldwide clinical issue. Astaxanthin red carotenoid pigment with antioxidant, anticancer, anti-inflammatory properties. The aim of this study was investigate the effect astaxanthin on liver its potential protective mechanisms. induced in mouse model using CCL4 (intraperitoneal injection, three times week for 8 weeks), administered everyday at doses (20, 40, 80 mg/kg). Pathological results indicated that significantly improved...
A meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 PUFAs) in lowering liver fat, enzyme (alanine aminotransferase (ALT), aspartate (AST), and gamma-glutamyltransferase (GGT) levels), blood lipids (triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low (LDL)) patients with nonalcoholic disease (NAFLD) or steatohepatitis (NASH). Methods. MEDLINE/PubMed, EMBASE, Cochrane Central Register Controlled Trials, CINAHL, Science...
Background Hepatic ischemia–reperfusion injury (HIRI) remains a pivotal clinical problem after hemorrhagic shock, transplantation, and some types of toxic hepatic injury. Apoptosis autophagy play important roles in cell death during HIRI. It is also known that N-acetylcysteine (NAC) has significant pharmacologic effects on HIRI including elimination reactive oxygen species (ROS) attenuation apoptosis. However, the NAC HIRI-induced have not been reported. In this study, we evaluated apoptosis...
Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance major problem treatment HCC. In this study, two sorafenib‐resistant HCC cell lines nude mouse subcutaneously tumor model were used to explore possible mechanisms leading sorafenib resistance, investigate whether aspirin could sensitivity hepatoma cells sorafenib. The combination resulted synergistic antitumor effect against liver tumors both vitro vivo . High...
Abstract Glycolysis, as an altered cancer cell-intrinsic metabolism, is essential hallmark of cancer. Phosphofructokinase (PFK) a metabolic sensor in the glycolytic pathway and restricting substrate availability for this enzyme has been researched extensively target chemotherapy. In present study, we investigated that effects epigallocatechin-3-gallate (EGCG), active component green tea, on inhibiting cell growth inducing apoptosis by promoting shift away from glycolysis aerobic...
The treatment for advanced primary hepatocellular carcinoma (HCC) is sorafenib (SORA), while HCC has become increasingly drug resistant with enhanced aerobic glycolysis. present study aimed to examine the chemotherapeutic effects of a flavonoid proanthocyanidin B2 (PB2) on HCC.Five kinds cell lines and LO2 were used test effect PB2 proliferation, cycle, apoptosis xenograft mouse model analyzed. Lentivirus overexpressed pyruvate kinase M2 (PKM2) or sh-PKM2 was verify target PB2. detailed...
ObjectiveThis study explored the potential association between Prognostic Nutritional Index (PNI) and incidence of non-alcoholic fatty liver disease (NAFLD) advanced fibrosis (AF) in adult population United States.MethodsInformation on 6409 participants ≥18 years old was downloaded from U.S. National Health Nutrition Examination Survey (NHANES) 2017 to 2020. Multivariate analysis combined with demographic factors assess relationships PNI, NAFLD, AF. A restricted cubic spline (RCS) used...