A5101519115- Phagocytosis and Immune Regulation
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Pancreatic function and diabetes
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- Advanced Glycation End Products research
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Erythrocyte Function and Pathophysiology
- Nanoparticles: synthesis and applications
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cell death mechanisms and regulation
- Calcium signaling and nucleotide metabolism
- Eosinophilic Disorders and Syndromes
- Photosynthetic Processes and Mechanisms
Shanghai Tenth People's Hospital
2015-2025
Tongji University
2015-2025
Nanjing Medical University
2015-2024
Jiangsu Province Hospital
2017-2024
Affiliated Hospital of North Sichuan Medical College
2024
Shihezi University
2024
Guangzhou University of Chinese Medicine
2018-2023
Zhaoqing University
2023
Baylor College of Medicine
2010-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2018-2023
Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potential for promoting functional behavioral recovery following SCI. However, MSCs are usually exposed normoxia in vitro, which differs greatly from the hypoxic micro-environment vivo. Thus, main purpose of this study was determine whether derived under hypoxia (HExos) exhibit greater effects on...
Approximately 10% of bone fractures do not heal satisfactorily, leading to significant clinical and socioeconomic implications. Recently, the role macrophages in regulating marrow stem cell (BMSC) differentiation through osteogenic pathway during fracture healing has attracted much attention. Methods: The tibial monocortical defect model was employed determine critical macrophage scavenger receptor 1 (MSR1) intramembranous ossification (IO) vivo. potential functions mechanisms MSR1 were...
Abstract Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and a severe health issue faced by elderly population. Mixed lineage kinase 3 (MLK3), member MAP3K family, associated with aging, inflammation, oxidative stress, related such as CHF. MLK3 has also been reported to play an important role in protecting against cardiomyocyte injury; however, its function myocardial fibrosis unknown. To investigate fibrosis, we inhibited expression MLK3, examined cardiac...
Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive hydrogel...
Abstract Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such is extremely challenging, as their loading capacity inherently limited by the compatibility between molecules and carrier materials. To mitigate drug-carrier limitation towards therapeutics encapsulation, we developed a sequential solidification strategy. In this strategy, precisely...
The Caenorhabditis elegans Bcl-2–like protein CED-9 prevents programmed cell death by antagonizing the Apaf-1–like cell-death activator CED-4. Endogenous and CED-4 proteins localized to mitochondria in wild-type embryos, which most cells survive. By contrast, embryos had been induced die, assumed a perinuclear localization. translocation EGL-1 was blocked gain-of-function mutation ced-9 but not dependent on ced-3 function, suggesting that precedes caspase activation execution phase of death....
// Weiqi Dai 1,* , Fan Wang Jie Lu Yujing Xia 1 Lei He Kan Chen Jingjing Li Sainan Tong Liu Yuanyuan Zheng Jianrong 1,2 Wenxia Yuqing Zhou 1,3 Qin Yin Huerxidan Abudumijiti Rongxia Rong Zhang Zhu Jing Yang Chengfen Huawei Yingqun Ling Xu 4 and Chuanyong Guo Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School Medicine, Shanghai, China 2 The First Clinical Medical College Nanjing University, Nanjing, 3 Affiliated Hospital Soochow Suzhou, Tongren Jiaotong...
Spinal cord injury (SCI) is a severe neurological disease; however, there no effective treatment for spinal injury. Neuroinflammation involves the activation of resident microglia and infiltration macrophages major pathogenesis SCI secondary considered to be therapeutic target SCI. Parthenolide (PN) has been reported exert anti-inflammatory effects in fever, migraines, arthritis, superficial inflammation; role PN therapeutics not clarified. In this study, we showed that could improve...
Spinal cord injury (SCI) is a catastrophic disease which has complicated pathogenesis including inflammation, oxidative stress and glial scar formation. Astrocytes are the most abundant cells in central nervous system fulfill homeostatic functions. Recent studies have described new reactive phenotype of astrocytes, A1, induced by may negative effects SCI. As Notch signaling pathway been linked to cell differentiation we aimed investigate its potential role astrocytes Contusive SCI rat model...
Apoptotic cells in animals are engulfed by phagocytic and subsequently degraded inside phagosomes. To study the mechanisms controlling degradation of apoptotic cells, we developed time-lapse imaging protocols developing Caenorhabditis elegans embryos established temporal order multiple events during engulfment phagosome maturation. These include sequential enrichment on membranes receptor cell death abnormal 1 (CED-1), large GTPase dynamin (DYN-1), phosphatidylinositol 3-phosphate (PI(3)P),...
Objective Astaxanthin, a potent antioxidant, exhibits wide range of biological activities, including atherosclerosis and antitumor activities. However, its effect on concanavalin A (ConA)-induced autoimmune hepatitis remains unclear. The aim this study was to investigate the protective effects astaxanthin ConA-induced in mice, elucidate mechanisms regulation. Materials Methods Autoimmune induced Balb/C mice using ConA (25 mg/kg), orally administered daily at two doses (20 mg/kg 40 mg/kg) for...
Abstract Background A sustained inflammatory response following spinal cord injury (SCI) contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major participants in response, transform into foamy macrophages after phagocytosing myelin debris, subsequently releasing factors and amplifying secondary injury. Here, we assessed effect of macrophage scavenger receptor 1 (MSR1) phagocytosis debris SCI explained its possible mechanism. Methods The model was employed...
Abstract New treatment strategies for spinal cord injury with good therapeutic efficacy are actively pursued. Here, acetalated dextran (AcDX), a biodegradable polymer obtained by modifying vicinal diols of dextran, is demonstrated to protect the traumatically injured cord. To facilitate its administration, AcDX formulated into microspheres (≈7.2 µm in diameter) droplet microfluidic technique. Intrathecally injected effectively reduce traumatic lesion volume and inflammatory response cord,...
Bleomycin (BLM) is a chemotherapeutic agent which associated with Idiopathic pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, bioflavonoid has been reported possess antioxidant, anti-inflammatory, wound healing, and antiapoptotic potential. To evaluate the therapeutic potential of hesperidin against BLM-induced decipher possible mechanism action. Intraperitoneal administration BLM (6 IU/kg) caused induction IPF in Sprague-Dawley rats. Rats were treated (25, 50, 100...
Background: Survival rates for Colorectal cancer (CRC) patients who experienced early relapse have usually been relatively low. Our study aims at developing an autophagy signature that could help to detect cases in CRC. Methods: Propensity score matching analysis was carried out between from the group and long-term survival GSE39582. For both groups, respectively, global expression changes were then analyzed identify differentially expressed prognostic related genes by conducting Linear...
Abstract Improving the function of blood–spinal cord barrier (BSCB) benefits functional recovery mice following spinal injury (SCI). The death endothelial cells and disruption BSCB at site contribute to secondary damage, ubiquitin–proteasome system is involved in regulating protein function. However, little known about regulation deubiquitinated enzymes their effect on after SCI. We observed that Sox17 predominantly localized significantly upregulated SCI LPS-treated brain microvascular...