A5100411165- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Spinal Cord Injury Research
- Antibiotic Resistance in Bacteria
- Spine and Intervertebral Disc Pathology
- Mesenchymal stem cell research
- Spinal Fractures and Fixation Techniques
- Allergic Rhinitis and Sensitization
- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Food Allergy and Anaphylaxis Research
- Bone health and treatments
- Animal Genetics and Reproduction
- Antibiotics Pharmacokinetics and Efficacy
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Bone Metabolism and Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
- E-commerce and Technology Innovations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chronic Myeloid Leukemia Treatments
Shanghai East Hospital
2014-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Nanjing University of Chinese Medicine
2024-2025
Jiangsu Province Hospital
2015-2024
Nanjing Medical University
2015-2024
Shanghai Ocean University
2018-2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Zunyi Medical University
2022-2024
Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive hydrogel...
Tyrophagus putresecentiae is an important mite species in rural and urban environments, causing sensitization allergic disease. While evidence suggests that microRNAs (miRNAs) may regulate the expression of allergen-encoding genes, no study has directly investigated this possibility. Here, gap was addressed by profiling miRNAs elucidating their target allergen messenger RNAs (mRNAs) species.Small RNA transcriptome libraries were constructed for eggs, larvae, nymphs, adults. After deep miRNA...
Abstract Background Dust mite extract contains multiple components that, while useful in clinical allergy diagnosis and treatment, can cause serious side effects. Defining of dust is important their contributions to allergic disease. This study aimed characterize a novel allergen, Der p 22. Methods We amplified the cDNA encoding 22 from total RNA Dermatophagoides pteronyssinus, inserted it into an expression construct for transformation competent cells. Purified recombinant (r) was tested...
Spinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition poses medical, economic, and social challenges. SCI is typically categorized into primary secondary injuries. Inflammation, oxidative stress, scar formation, the immune microenvironment impede axon regeneration subsequent functional restoration. Numerous studies have shown that destruction of blood-brain barrier (BBB) microvessels crucial factor in severe injury....
Abstract Background Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate safety and efficacy intravenous infusion human umbilical cord-derived MSCs (HUC-MSCs) patients with aging frailty. Methods randomized, double-blind, placebo-controlled trial, participants diagnosed frailty were randomly assigned receive administrations HUC-MSCs or placebo. All serious adverse events AEs monitored treatment...
Root rot of Panax notoginseng has received great attention due to its threat on the plantation and sustainable utilization P. notoginseng. To suppress root-rot disease, natural ingredients are importance because their environment friendly properties. In this study, we found that methanol extract from Artemisia annua leaves strong antifungal effects growth Fusarium oxysporum solani resulting into disease. Essential oil (EO) thereof was be most active. GC-MS analysis revealed 58 camphor,...
Neural stem cell-derived small extracellular vesicles (NSC-sEVs) play an important role in the repair of tissue damage. Our previous vitro and vivo studies found that preconditioning with NSC-sEVs promoted recovery functional behaviors following spinal cord injury by activating autophagy. However, underlying mechanisms for such observations remain unclear. In this study, we further explored which via We contain 14-3-3t protein, overexpression or knockdown enhanced decreased autophagy,...
Abstract In pneumonia, the deficient or delayed pathogen clearance can lead to proliferation and subsequent overactive immune responses, inducing acute lung injury (ALI). While screening human genome coding genes using our peripheral blood cell chemotactic platform, we unexpectedly find SLP adaptor CSK interacting membrane protein (SCIMP), a with neutrophil activity secreted during ALI. However, specific role of SCIMP in ALI remains unclear. this study, investigate secretion exosomes (SCIMP...
Abstract Background Percutaneous kyphoplasty is the main method in treatment of thoracolumbar osteoporotic compression fractures. However, much radiation exposure during operation harms health surgeons and patients. In addition, accuracy this surgery still needs to be improved. This study aimed assess clinical efficacy Tirobot-assisted vertebroplasty treating fracture. Methods Included retrospective cohort were 60 patients (60–90 years) who had undergone unilateral for fracture at our...
Airway inflammation is a prominent feature of asthma and may play an important role in disease pathophysiology. Despite the increasing incidence worldwide, reliable diagnostic biomarkers are lacking widely lead to misdiagnosis. Neutrophil-lymphocyte ratio (NLR) biomarker systemic inflammation, addition NLR-alanine aminotransferase (NAR) NLR-albumin (NBR). The aim this study was evaluate associations NLR, NAR, NBR with diagnosis childhood determine if they can aid clinical diagnosis.This...
ABSTRACT Danatinib, a brand‐new compound synthesized in our laboratory for the treatment of acute myeloid leukemia (AML), demonstrates remarkable antitumor activity. However, pharmacokinetic profile Danatinib mice was short with its half‐life only 0.476 h. To address this issue and optimize therapeutic efficacy, study investigated metabolic profiles mice, both vitro vivo, using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry (UHPLC/Q‐TOF MS)...
The relationship between dyslipidemia and mortality varies by age, with an inverse association observed in the oldest age groups. There is limited research examining lipid profiles' correlation short-term risk older adults. This study aimed to investigate associations of profiles ratios 28-day non-surgical patients critical illnesses. A retrospective cohort was conducted illness who were admitted ICU Shanghai East Hospital January 2022 November 2024. All data collected via hospitalization...
Background/Aims: The purpose of this study was to investigate the role autophagy in oxygen-glucose-deprivation/reoxygenation (OGD/R) injury rat neurons. Methods and results: Cortical neurons were isolated from Sprague-Dawley rats identified by immunofluorescence. cortical randomly assigned one four groups: control group (I), experimental (OGD/R group, II), JNK inhibitor pretreatment (III) + OGD/R (IV). Neuronal cell viability significantly decreased after 6h 12h reoxygenation Group IV (P...
Abstract The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused relatively short-lived proteins; how ubiquitylation modifies the and its regulatory effect adult lifespan is unclear. Here we profile age-dependent dynamics proteomes in Drosophila by mass spectrometry using isotope switching coupled antibody-enriched ubiquitylome analysis. Our data describe landscapes somatic...
Functional dyspepsia (FD) is a prevalent global disorder of the upper digestive tract characterized by functional impairment. It often coexists with anxiety/depression, significantly impairing occupational productivity and overall quality life. This study aimed to identify emerging patterns prominent themes within FD anxiety/depression research through bibliometric analysis help explore new innovative avenues for investigating this type FD. A comprehensive review literature encompassing was...
Background/Aims: Endogenous parathyroid hormone (PTH) plays an important role in fracture healing. This study investigated whether endogenous PTH regulates healing by bone morphogenetic protein (BMP) and/or the transforming growth factor-β (TGF-β) signaling pathway. Methods: Eight-week-old wild-type (WT) and PTH-knockout (PTH KO) male mice were selected, models of open right-femoral constructed. Fracture callus characteristics two groups compared X-ray, micro-computed tomography,...