A5100421839- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Hippo pathway signaling and YAP/TAZ
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- Protein Degradation and Inhibitors
- Complexity and Algorithms in Graphs
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Glycosylation and Glycoproteins Research
- Adenosine and Purinergic Signaling
- Bone health and treatments
- Endoplasmic Reticulum Stress and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Game Theory and Voting Systems
- Palliative Care and End-of-Life Issues
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Auction Theory and Applications
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Formal Methods in Verification
- Chromatin Remodeling and Cancer
University of Pennsylvania
2009-2025
Women's Hospital, School of Medicine, Zhejiang University
2021-2025
Guangxi Medical University
2025
Nantong University
2025
University of Toledo
2025
Affiliated Hospital of Nantong University
2025
Washington University in St. Louis
2022-2024
Medizinische Hochschule Hannover
2024
Radboud University Medical Center
2024
Shanghai East Hospital
2024
In vitro hypoxic preconditioning (HP) of mesenchymal stem cells (MSCs) could ameliorate their viability and tissue repair capabilities after transplantation into the injured through yet undefined mechanisms. There is also experimental evidence that HP enhances expression both stromal-derived factor-1 (SDF-1) receptors, CXCR4 CXCR7, which are involved in migration survival MSCs vitro, but little known about role vivo therapeutic effectiveness renal ischemia/reperfusion (I/R) injury. Here, we...
Abstract The MarkVCID consortium was formed under cooperative agreements with the National Institute of Neurologic Diseases and Stroke (NINDS) on Aging (NIA) in 2016 goals developing validating biomarkers for cerebral small vessel diseases associated vascular contributions to cognitive impairment dementia (VCID). Rigorously validated have consistently been identified as crucial multicenter studies identify effective strategies prevent treat VCID, specifically detect increased VCID risk,...
Abstract Background Mesenchymal stem cells (MSCs) hold a great promise for cell-based therapy in the field of regenerative medicine. In this study, we aimed to evaluate safety and efficacy intravenous infusion human umbilical cord-derived MSCs (HUC-MSCs) patients with aging frailty. Methods randomized, double-blind, placebo-controlled trial, participants diagnosed frailty were randomly assigned receive administrations HUC-MSCs or placebo. All serious adverse events AEs monitored treatment...
Importance Among patients with advanced solid malignant tumors, early specialty palliative care (PC) is guideline recommended, but strategies to increase PC access and effectiveness in community oncology are lacking. Objective To test whether algorithm-based defaults opting out accountable justification embedded the electronic health record (EHR) completed visits. Design, Setting, Participants This 2-arm cluster randomized clinical trial was conducted from November 1, 2022, December 31,...
Tryptophan is metabolized along the kynurenine and serotonin pathways, resulting in formation of metabolites, neuroactive melatonin. Each pathway critical for maintaining healthy homeostasis. However, two pathways are extremely unequal their ability to degrade tryptophan, little known about mechanisms balance between them. Here, we demonstrated that PC12 cells, a change expression key genes one resulted other. Melatonin, end product pathway, played an important role tryptophan metabolism by...
We study the problem of estimating maximum matching size in graphs whose edges are revealed a streaming manner. consider both insertion-only streams and dynamic present new upper lower bound results for models. On front, we show that an $\alpha$-approximate estimate can be computed using $\widetilde{O}({n^2/\alpha^4})$ space, $\widetilde{O}(n/\alpha^2)$-space. prove any $\alpha$-approximation algorithm graph requires $\Omega(\sqrt{n}/\alpha^{2.5})$ bits even if underlying is sparse has...
Abstract The therapeutic efficiency of allogenic/intrinsic neural stem cells (NSCs) after spinal cord injury is severely compromised because the hostile niche at lesion site incurs massive astroglial but not neuronal differentiation NSCs. Although many attempts are made to reconstruct a permissive for nerve regeneration, solely using living cell material build an all‐in‐one, multifunctional, promoting while inhibiting NSCs reported. Here, ectomesenchymal (EMSCs) reported serve as living,...
Chondrogenesis is a major contributor to skeletal development and maintenance, as well bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) key regulator of osteogenesis adipogenesis, but how TAZ regulates chondrogenesis remains undefined. Here, we found that expression gradually increased during chondrogenic differentiation. Deletion in chondrocyte lineage impaired articular growth plate, the TAZ-deficient mice. Consistently, loss fracture healing. Mechanistically, ectopic...
Cathepsins play a role in regulation of cell function through their presence the nucleus. However, Cathepsin K (Ctsk) as an epigenetic regulator osteoclasts remains unknown. Our data demonstrated that
Fibromyalgia is characterised by widespread chronic pain and often accompanied comorbidities such as sleep disorders, anxiety, depression. Because it many adverse symptoms lack of effective treatment, important to search for the pathogenesis treatment fibromyalgia. Astaxanthin, a carotenoid pigment known its anti-inflammatory antioxidant properties, has demonstrated analgesic effects in neuropathic pain. However, impact on fibromyalgia remains unclear. Therefore, this study, we constructed...
Following the publication of this paper, an interested reader drew to attention authors and Editorial Office that a number data panels shown for cell migration assays in Figs. 1, 3, 4 5 contained overlapping data, such indicated results purportedly representing different experiments were derived from same original sources. Furthermore, it was noted scratch‑wound assay had apparently been included four Fig. 5D intended represent performed under conditions. After having investigated matter...
Cell division cycle-associated 5 (CDCA5) can regulate cell cycle-related proteins to promote the proliferation of cancer cells. The purpose present study was investigate expression level CDCA5 in prostate (PCa) and its effect on PCa progression. signalling pathway by which functions through also attempted elucidate. Clinical specimens patients were collected from Second Hospital Tianjin Medical University. tissues paracancerous detected RT-qPCR analysis IHC. relationship between survival...
In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity mortality, poorer vaccination efficiency. Many factors, such as genetics, diet, lifestyle, impact aging. This study aimed investigate how immune responses change with age in healthy Dutch Tanzanian individuals identify common metabolites associated an aged profile. We performed untargeted metabolomics from plasma age-associated metabolites, we correlated their concentrations ex-vivo cytokine...
The ability to reason about changes in a distributed system's state enables network administrators better diagnose protocol misconfigurations, detect intrusions, and pinpoint performance bottlenecks. We propose novel provenance model called Distributed Time-aware Provenance (DTaP) that aids forensics debugging systems by explicitly representing time, state, changes. Using Datalog abstraction for modeling protocols, we prove the DTaP provides sound complete representation correctly captures...
Previous study has demonstrated that long noncoding RNA cyclin-dependent kinase inhibitor 2B antisense 1 (CDKN2B-AS1) was abnormally expressed in diabetic nephropathy (DN). However, the underlying mechanism allows CDKN2B-AS1 progression of DN remains to be further elucidated.Peripheral blood cells 24 diabetes patients with and 20 without were collected. Human glomerular mesangial (HGMC) cultured high glucose or low medium. The expression levels CDKN2B-AS1, microRNA (miR)-424-5p mobility...
Background Effective therapeutic strategies to address intestinal complications after radiation exposure are currently lacking. Mesenchymal stem cells (MSCs), which display the ability repair injured intestine, have been considered as delivery vehicles for genes. In this study, we evaluated effect of hepatocyte growth factor (HGF)-gene-modified MSCs on radiation-induced injury (RIII). Methods Female 6- 8-week-old mice were radiated locally at abdomen with a single 13-Gy dose and then treated...
Osteosarcoma is the most common primary malignancy of bone in children and adolescents. Others our previous studies have shown that Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) as core components Hippo pathway are crucial regulators osteosarcoma formation progression. Recent demonstrated verteporfin (VP) an inhibitor YAP/TAZ signaling xenograft osteosarcoma. However, whether VP can inhibit mice unknown. Mutations Trp53 Rb1 occur approximately 50~70%...
Abstract: Cyclin-Dependent Kinase 8 (CDK8) is a paracrine transcriptional regulator involved in regulating cellular stress response, growth, and neurological functions conjunction with mediator complex subunits 12 (MED12), MED13, cyclin C. Studying the relationship be-tween CDK8 cervical squamous cell carcinoma (CESC) has significant clinical implications diagnosis, treatment, prognosis. Therefore, we analyzed between poor prognosis of CESC. The results indicated that was overexpressed CESC,...