A5100438230- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Sleep and Wakefulness Research
- China's Ethnic Minorities and Relations
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Photoreceptor and optogenetics research
- Vibrio bacteria research studies
- Neuroscience and Neural Engineering
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Ferroptosis and cancer prognosis
- Bacteriophages and microbial interactions
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Plant and animal studies
- RNA regulation and disease
Shantou University
2025
Shantou University Medical College
2025
Southern University of Science and Technology
2023-2025
Shandong University
2018-2025
Allen Institute for Brain Science
2018-2025
Johns Hopkins University
2017-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Women's Hospital, School of Medicine, Zhejiang University
2019-2025
Agricultural Information Institute
2024
Egocentric representation of objects The lateral entorhinal cortex (LEC) and medial (MEC) are the two major cortical projections to hippocampus. discovery a variety functional cell types in MEC has greatly advanced our understanding anatomy entorhinal-hippocampal circuits. However, function LEC behavioral correlates cells still not fully understood. Wang et al. analyzed firing properties neurons. They found that used different reference frames, with encoding egocentrically. Science , this...
Optogenetics is a valuable tool for studying the mechanisms of neurological diseases and now being developed therapeutic applications. In rodents macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While photoexcitation neurons has achieved, noninvasive inhibition treating hyperexcitability-induced disorders remained elusive. There critical need effective inhibitory tools that are highly light-sensitive capable suppressing neuronal activity...
Background and Purpose— Activation of NMDA subtypes glutamate receptors is implicated in cell damage induced by ischemia as well for the establishment ischemic tolerance after preconditioning animal models. We investigated contributions NR2A- NR2B-containing to death a rat model transient global ischemia. Methods— Transient was produced rats 4-vessel occlusion. Neuronal injury analyzed Fluoro-Jade B Nissl staining. Phosphorylation CREB detected Western blotting immunohistochemistry. In situ...
Data from clinical trials for hemophilia B using adeno-associated virus (AAV) vectors have demonstrated decreased transgenic coagulation factor IX (hFIX) expression 6-10 weeks after administration of a high vector dose. While it is likely that capsid-specific cytotoxic T lymphocytes eliminate vector-transduced hepatocytes, thereby resulting in hFIX, this observation not intuitively consistent with restored hFIX levels following prednisone application. Although the innate immune response...
Cancer morbidity and mortality can be reduced if the cancer is detected early. Cell-free DNA (cfDNA) fragmentomics emerged as a novel epigenetic biomarker for early detection, however, it still at its infancy requires technical improvement. We sought to apply single-strand sequencing technology, measuring genetic fragmentomic features of cfDNA evaluate performance in detecting multiple cancers.
Abstract: Cyclin-Dependent Kinase 8 (CDK8) is a paracrine transcriptional regulator involved in regulating cellular stress response, growth, and neurological functions conjunction with mediator complex subunits 12 (MED12), MED13, cyclin C. Studying the relationship be-tween CDK8 cervical squamous cell carcinoma (CESC) has significant clinical implications diagnosis, treatment, prognosis. Therefore, we analyzed between poor prognosis of CESC. The results indicated that was overexpressed CESC,...
The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information CA3 region. In turn, attractor dynamics in perform a pattern completion or error correction operation before sending its output CA1. mouse model of congenital hypoplasia DG, deficiency Wntless (Wls) gene, specifically cells expressing Gfap-Cre , which targets neuronal progenitors, led an almost total absence granule modestly impaired performance...
Understanding the evolving patterns of cardiovascular disease (CVD) burden attributable to ambient particulate matter pollution (APMP) is essential. Furthermore, research on underlying mechanisms has mostly been limited laboratory and animal models, with few large-scale population-based studies. Using data from Global Burden Disease Study (GBD) 2021, we analyzed disability-adjusted life years mortality for CVD APMP (measured as [PM]2.5) 1990 2021. We examined shifts in between household air...
Classical studies on the development of ocular dominance (OD) organization in primary visual cortex (V1) have revealed a postnatal critical period (CP), during which inputs between two eyes are most effective shaping cortical circuits through synaptic competition. A brief closure one eye CP caused pronounced shift response preference V1 neurons toward open eye, form plasticity developing V1. However, it remains unclear what particular property binocular is responsible for mediating this...
Adeno-associated virus (AAV) vectors have been successfully applied in hemophilia clinical trials. However, this approach is limited to patients without AAV-neutralizing antibodies (NAbs). In study, we explored the feasibility of AAV re-administration A dogs treated initially 8 years ago with AAV8.canine FVIII. After two NAb-negative AAV8 carrying human factor VIII (hFVIII), along proteasome inhibitor bortezomib, observed a phenotypic improvement both that persisted one dog. Phenotypic...
Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of vectors: hepatocyte tropism neutralizing antibodies (Nabs). In this study, we attempted to isolate variants the ability transduce hepatocytes escape Nabs using a directed evolution approach
As a fundamental global staple crop, rice plays pivotal role in human nutrition and agricultural production systems. However, its complex genetic architecture extensive trait variability pose challenges for breeders researchers optimizing yield quality. Particularly to expedite breeding methods like genomic selection, isolating core SNPs related target traits from genome-wide data reduces irrelevant mutation noise, enhancing computational precision efficiency. Thus, exploring efficient...
Protein disulfide isomerases (PDIs) are essential catalysts for the formation and isomerization of bonds in diverse substrate proteins exert multiple functions under pathophysiological conditions. Here, we show that anterior gradient 2 (AGR2), a member PDIs, acts as negative regulator antiviral immunity. RNA virus infection stimulated expression secretion AGR2 epithelial cells. While is absent immune cells, both intracellular extracellular compromised type I interferon (IFN-I) production...
Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the results suggest that capsid-specific CD8+T cell response has a negative effect on therapeutic success. In an vitro analysis using engineered AAV carrying immune-dominant SIINFEKL peptide capsid backbone, we previously demonstrated antigen presentation from full (genome containing) capsids requires endosome escape and is proteasome dependent no induced empty...
Abstract Optogenetics is a valuable tool for studying the mechanisms of neurological diseases and now being developed therapeutic applications. In rodents macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. While photoexcitation neurons has achieved, noninvasive inhibition treating hyperexcitability-induced disorders remained elusive. There critical need effective inhibitory tools that are highly light-sensitive capable suppressing neuronal...