A5045685144- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Mesenchymal stem cell research
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Plant-Microbe Interactions and Immunity
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Plant nutrient uptake and metabolism
- Autophagy in Disease and Therapy
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Plant tissue culture and regeneration
- Plant Pathogenic Bacteria Studies
- Glycosylation and Glycoproteins Research
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Supramolecular Self-Assembly in Materials
Central South University
2016-2025
Hainan Medical University
2020-2023
Ludong University
2021-2022
Haikou City People's Hospital
2017-2021
China Agricultural University
2021
Case Western Reserve University
2020
Cornell University
2020
Hainan University
2016-2019
N6-methyladenosine (m6A) is the most common form of messenger RNA (mRNA) modification. An increasing number studies have proven that m6A methylation regulators are overexpressed in many cancers and participate development cancer through dynamic regulation regulators. However, prognostic role bladder (BC) poorly understood. In present study, we downloaded mRNA expression data from The Cancer Genome Atlas (TCGA) database corresponding clinical information. relationship between...
Verticillium wilt is a severe plant disease that causes massive losses in multiple crops. Increasing the resistance to critical challenge worldwide. Here, we report hemibiotrophic dahliae-secreted Asp f2-like protein VDAL leaf wilting when applied cotton leaves vitro but enhances V. dahliae overexpressed Arabidopsis or without affecting growth and development. interacts with E3 ligases U-box 25 (PUB25) PUB26 ubiquitinated by PUBs vitro. However, not degraded PUB25 planta. Besides, pub25...
Background: Ferroptosis is closely related to the occurrence and development of cancer. An increasing number studies have induced ferroptosis as a treatment strategy for However, predictive value ferroptosis-related lncRNAs in bladder cancer (BC) still need be further elucidated. The purpose this study was construct signature based on long noncoding RNAs (lncRNAs) predict prognosis BC patients. Methods: We downloaded RNA-seq data corresponding clinical prognostic from Cancer Genome Atlas...
Previous study has demonstrated that long noncoding RNA cyclin-dependent kinase inhibitor 2B antisense 1 (CDKN2B-AS1) was abnormally expressed in diabetic nephropathy (DN). However, the underlying mechanism allows CDKN2B-AS1 progression of DN remains to be further elucidated.Peripheral blood cells 24 diabetes patients with and 20 without were collected. Human glomerular mesangial (HGMC) cultured high glucose or low medium. The expression levels CDKN2B-AS1, microRNA (miR)-424-5p mobility...
Bile duct injuries remain a significant clinical challenge following hepatobiliary surgeries. Recently, 3D-printed tubular scaffolds have shown promise as effective solutions for bile tissue repair. This study presents novel bi-layered scaffold, fabricated using advanced three-dimensional printing technology. The inner layer of this scaffold is constructed from poly(ε-caprolactone) methacrylate (PCLMA), which imparts high mechanical strength. outer composed biocompatible methacrylated...
Bladder cancer remains one of the most common malignant tumors that threatens human health worldwide. It imposes a heavy burden on patients and society due to high medical costs associated with its easy metastasis recurrence. Although several treatment options for bladder are available, their clinical efficacy unsatisfactory. Therefore, actively exploring new drugs mechanisms action is very important. Scabertopin major sesquiterpene lactones found in Elephantopus scaber L. Sesquiterpene...
Abnormal autophagy is closely related to the development of cancer. Many studies have demonstrated that plays an important role in biological function clear cell renal carcinoma (ccRCC). This study aimed construct a prognostic signature for ccRCC based on autophagy-related genes (ARGs) predict prognosis ccRCC. Differentially expressed ARGs were obtained from RNA-seq data The Cancer Genome Atlas (TCGA) database. enriched by gene ontology (GO) and Kyoto Encyclopedia Genes Genomes (KEGG). used...
Abstract To investigate the effect of low-intensity pulsed ultrasound (LIPUS) on proliferation human adipose-derived mesenchymal stromal cells (hASCs) and uncovered its stimulation mechanism. LIPUS at 30 mW/cm 2 was applied for 5 min/day to promote hASCs. Flow cytometry used study cell surface markers, cycle, apoptosis The hASCs detected by counting kit-8, cycle assay, RT-PCR. expression cytokines determined ELISA. differences between transcriptional genes metabolites were analyzed...
We successfully fabricated artificial bile duct via 3D printing technique which was composed of poly (lactic-co-glycolic acid) (PLGA) and gelatin methacrylate (GelMA). The PLGA-inner layer provided sufficient strength to support the contraction, GelMA-outer possessed good biocompatibility provide a living environment for cells. Moreover, IKVAV laminin peptide (Ile-Lys-Val-Ala-Val) ultrasmall superparamagnetic iron oxide (USPIO) were used regulate scaffold cell adhesion magnetic resonance...
Background: Ras-related C3 botulinum toxin substrate 3 (Rac3) is overexpressed in malignancies and promotes tumor progression. However, the correlations between Rac3 expression clinicopathological characteristics prognoses of patients with bladder cancer (BC) remain unclear. Methods: Data from The Cancer Genome Atlas (TCGA) were used to analyze BC normal tissues validated using Oncomine database, quantitative real-time PCR (qRT-PCR) western blot. Kaplan-Meier method was relationship...
Background: RNA methylation modification plays an important role in immune regulation. m7G is emerging research hotspot the field. However, its tumor microenvironment of kidney renal clear cell carcinoma (KIRC) still unclear. Methods: We analyzed expression profiles 29 regulators KIRC, integrated multiple datasets to identify a novel regulator-mediated molecular subtype, and developed score. evaluated microenvironments clusters correlation score with cells drug sensitivity. tested predictive...
Human intracellular chloride channel 3 (CLIC3) is involved in the development of various cancers, but expression and prognostic value CLIC3 mRNA bladder cancer (BC) remain unclear.The gene data clinical information were obtained from Gene Expression Omnibus (GEO) database verified Oncomine The Cancer Genome Atlas (TCGA) database. BC tissues adjacent normal was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Kaplan-Meier method used to analyze relationship between...
Polyamine metabolism (PM) is closely related to the tumor microenvironment (TME) and involved in antitumor immunity. Clear cell renal carcinoma (ccRCC) not only has high immunogenicity but also significant metabolic changes. However, role of PM immune ccRCC remains unclear. This study aimed reveal prognostic value PM-related genes (PMRGs) expression their correlation with TME. The levels PMRGs different cells were characterized single-cell sequencing analysis. PMRG pattern 777 patients was...
// Fei Wang 1, * , Yingai Zhang 2, Shunlan 2 Yadong 3 Dinglan Wu 4 Chong 5 Yuanhui Gao Xi Liu Weifu 1 and Shufang Department of Urology, People's Hospital Hainan Province, Haikou, Hainan, 570311, P.R. China Central Laboratory, Haikou Hospital, South University Xiangya School Medicine Affiliated 570208, First Sun Yat-Sen University, Guangzhou, Guangdong, 510080, Shenzhen Southern Medical Shenzhen, 518110, Joint first author Correspondence to: Zhang, email: shufangzhanghk@163.com Wang,...
Background: Many studies have shown that solute carrier family 35 member F2 (SLC35F2) plays a key role in the biological processes of multiple cancers. However, there been no reports on SLC35F2 occurrence and development bladder cancer (BC). Methods: expression data clinical prognostic information from BC patients were obtained databases. was verified by quantitative real-time PCR (qRT-PCR). The influence knockdown proliferation, apoptosis, migration invasion 5637 T24 cell lines studied,...
Non-muscle-invasive bladder cancer (NMIBC) is a common tumor of the urinary system. Given its high rates recurrence, progression, and drug resistance, NMIBC seriously affects quality life limits survival time patients. Pirarubicin (THP) infusion chemotherapy recommended by guidelines for NMIBC. Although widespread use THP reduces recurrence rate NMIBC, 10-50% patients still suffer from which closely related to resistance drugs. This study was performed screen critical genes causing in cell...
Abstract SVIL is a member of the villin/gelsolin superfamily and responsible for encoding supervillin. It has been reported to be closely related occurrence development various tumors. However, mechanism in bladder cancer not yet. In this research, we evaluated relationship between expression public dataset examined cell lines, tissue microarrays patients our cohort. Our work determined that was significantly lower than normal tissue. tissues, high associated with poor prognosis. This kind...