A5100455469- Bone Tissue Engineering Materials
- Marine Sponges and Natural Products
- Diatoms and Algae Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Marine Biology and Environmental Chemistry
- biodegradable polymer synthesis and properties
- Calcium Carbonate Crystallization and Inhibition
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Bone health and treatments
- Paleontology and Stratigraphy of Fossils
- Enzyme function and inhibition
- Geochemistry and Elemental Analysis
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Geological and Geochemical Analysis
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Bone and Dental Protein Studies
- Hepatitis C virus research
- Bone Metabolism and Diseases
- Geochemistry and Geologic Mapping
- Silk-based biomaterials and applications
- Biosensors and Analytical Detection
- Microbial Natural Products and Biosynthesis
Xuzhou Central Hospital
2025
Guizhou University
2025
Johannes Gutenberg University Mainz
2015-2024
University Medical Center of the Johannes Gutenberg University Mainz
2015-2024
Huazhong Agricultural University
2015-2024
China Medical University
2019-2024
Hefei Normal University
2023-2024
Institute of Oceanology
2015-2024
Chinese Academy of Sciences
2010-2024
Tsinghua University
2002-2024
In vitro hypoxic preconditioning (HP) of mesenchymal stem cells (MSCs) could ameliorate their viability and tissue repair capabilities after transplantation into the injured through yet undefined mechanisms. There is also experimental evidence that HP enhances expression both stromal-derived factor-1 (SDF-1) receptors, CXCR4 CXCR7, which are involved in migration survival MSCs vitro, but little known about role vivo therapeutic effectiveness renal ischemia/reperfusion (I/R) injury. Here, we...
The present study examined whether transplantation of adherent bone marrow-derived stem cells, termed pMultistem, induces neovascularization and cardiomyocyte regeneration that stabilizes bioenergetic contractile function in the infarct zone border (BZ) after coronary artery occlusion.Permanent left anterior descending occlusion swine caused ventricular remodeling with a decrease ejection fraction from 55+/-5.6% to 30+/-5.4% (magnetic resonance imaging). Four weeks occlusion, BZ myocardium...
The genomic sequences of viruses that are highly mutable and cause chronic infection tend to diverge over time. We report these changes represent both immune-driven selection and, in the absence immune pressure, reversion toward an ancestral consensus. Sequence hepatitis C virus (HCV) structural nonstructural genes were studied a cohort women accidentally infected with HCV rare common-source outbreak. compared present serum obtained 18–22 yr after shared inoculum found evolved along distinct...
Stromal-derived factor 1alpha (SDF-1alpha) is a key stem cell homing that crucial for mobilization of cells from bone marrow to peripheral blood and subsequent engraftment the tissue diseased organs. It has been reported SDF-1alpha transiently over-expressed in ischemic myocardium. Therefore, there may be limited time window after acute myocardial infarction (AMI) during which are recruited injured myocardium repair. This study aimed at investigating whether controlled release via novel...
A potential therapy for myocardial infarction is to deliver isolated mesenchymal stem cells (MSCs) the infarcted site. key issue with this technology development of a suitable system MSC delivery. Our delivery interest fibrin-based patch used entrap during polymerization. This vehicle has many advantages; however mechanical properties and limited capacity tailoring cell response may restrict its application. We have developed PEGylated fibrin transplantation by modifying fibrinogen (Fgn)...
Abstract Glioblastoma multiforme (GBM) is a devastating brain tumor with poor prognosis and low median survival time. Standard treatment includes radiation chemotherapy the DNA alkylating agent temozolomide (TMZ). However, large percentage of tumors are resistant to cytotoxic effects TMZ-induced lesion O6-methylguanine due elevated expression repair protein O6-methylguanine-DNA methyltransferase (MGMT) or defect in mismatch (MMR) pathway. Although majority lesions (N7-methylguanine...
Abstract SIRT3 is a key mitochondrial protein deacetylase proposed to play roles in regulating metabolism but there has been considerable debate about its actual size, the sequences required for activity, and subcellular localization. A previously cloned mouse high sequence similarity with C‐terminus of human lacks an N‐terminal targeting no detectable deacetylation activity vitro . Using 5′ rapid amplification cDNA ends, we entire SIRT3, as well rat rabbit SIRT3. Importantly, find that...
We investigated the effect of bioglass (bioactive glass) on growth and mineralization bone-related SaOS-2 cells, encapsulated into a printable biodegradable alginate/gelatine hydrogel. The hydrogel was supplemented either with polyphosphate (polyP), administered as polyP•Ca2+-complex, or silica, biosilica that had been enzymatically prepared from ortho-silicate by silicatein. These hydrogels, together were bioprinted to computer-designed scaffolds. results revealed (nano)particles, size 55...
Physiological amorphous polyphosphate nano/micro-particles, injectable and implantable, attract stimulate MSCs into implants for tissue regeneration.
Here, we studied the potential role of inorganic polyphosphate (polyP) as an energy source for ADP and ATP formation in extracellular space. In SaOS-2 cells, show that matrix vesicles are released into space after incubation with polyP. These contain both alkaline phosphatase (ALP) adenylate kinase (AK) activities (mediated by ALPL AK1 enzymes). Both enzymes translocate to cell membrane response To distinguish process(es) AMP during ALP hydrolysis from generated via AK reaction, inhibition...
Abstract The management of diabetic wounds (DWs) continues to pose a significant challenge in the field medicine. DWs are primarily prevented from healing due damage macrophage efferocytosis and fibroblast dysfunction. Consequently, treatment strategy that involves both immunoregulation promotion extracellular matrix (ECM) formation holds promise for DWs. Nevertheless, existing methods necessitate complex interventions associated with increased costs, example, use cytokines cell therapy,...
Current therapies for heart failure due to transmural left ventricular (LV) infarction are limited. We have developed a novel patch method delivering autologous bone marrow stem cells sites of myocardial the purpose improving LV function and preventing aneurysm formation. The consisted fibrin matrix seeded with porcine mesenchymal labeled lacZ. applied this swine model postinfarction remodeling. Myocardial was produced by using 60-min occlusion anterior descending coronary artery distal...
Optical scattering coefficient from ex vivo unfixed normal and malignant ovarian tissue was quantitatively extracted by fitting optical coherence tomography (OCT) A-line signals to a single model. 1097 average measurements at wavelength of 1310 nm were performed 108 sites obtained 18 ovaries. The the group consisted 833 88 2.41 mm−1 (±0.59), while 264 20 1.55 (±0.46). showed significant lower than (p < 0.001). amount collagen within OCT imaging depth analyzed histological section stained...