A5042982991- Marine Sponges and Natural Products
- Diatoms and Algae Research
- Marine Biology and Environmental Chemistry
- Invertebrate Immune Response Mechanisms
- Calcium Carbonate Crystallization and Inhibition
- Paleontology and Stratigraphy of Fossils
- Marine Invertebrate Physiology and Ecology
- Bone Tissue Engineering Materials
- Aquaculture disease management and microbiota
- Cell death mechanisms and regulation
- Marine Ecology and Invasive Species
- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Protist diversity and phylogeny
- Geochemistry and Elemental Analysis
- Cytomegalovirus and herpesvirus research
- Synthetic Organic Chemistry Methods
- biodegradable polymer synthesis and properties
- Bone health and treatments
- Venomous Animal Envenomation and Studies
- Organ Transplantation Techniques and Outcomes
- Bone Metabolism and Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Environmental Toxicology and Ecotoxicology
- Immune Response and Inflammation
Johannes Gutenberg University Mainz
2010-2021
University Medical Center of the Johannes Gutenberg University Mainz
2010-2020
Synthetic Biologics (United States)
2020
University of Applied Sciences Mainz
2019
NanotecMARIN (Germany)
2010-2012
Biologie Labor
2003
Freie Universität Berlin
1992-1993
A clear picture of animal relationships is a prerequisite to understand how the morphological and ecological diversity animals evolved over time. Among others, placement acoelomorph flatworms, Acoela Nemertodermatida, has fundamental implications for origin evolution various organ systems. Their position, however, been inconsistent in phylogenetic studies using one or several genes. Furthermore, among least stable taxa recent phylogenomic analyses, which simultaneously examine many genes...
Sponges (phylum Porifera) are the phylogenetically oldest metazoa; as filter feeders, they abundantly exposed to marine microorganisms. Here we present data indicating that demosponge Suberites domuncula is provided with a recognition system for gram-negative bacteria. The lipopolysaccharide (LPS)-interacting protein was identified receptor on sponge cell surface, which recognizes bacterial endotoxin LPS. cDNA isolated, and (Mr 49,937) expressed. During binding LPS, dimerizes interacts...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 178:205-219 (1999) - doi:10.3354/meps178205 Establishment of a primary cell culture from sponge: primmorphs Suberites domuncula Werner E. G. Müller1,*, Matthias Wiens1, Renato Batel2, Renate Steffen1, Heinz C. Schröder1, Radovan Borojevic3, Marcio Reis Custodio1,3 1Institut für Physiologische Chemie,...
During evolution and with the emergence of multicellular animals, need arose to ward off foreign organisms that threaten integrity animal body. Among many different receptors participate in recognition microbial invaders, toll-like (TLRs) play an essential role mediating innate immune response. After binding distinct components, TLRs activate intracellular signaling cascades result induced expression diverse antimicrobial molecules. Because sponges (phylum Porifera) are filter feeders, they...
Treatment with monoclonal IL-2 receptor antibodies has been successfully used for immunosuppressive induction therapy following organ transplantation in the recent past. The present study was conducted to compare first time a cyclosporine-based quadruple regimen including antibody or ATG as after orthotopic liver transplantation. In two groups of 33 patients each, postoperative survival, graft biopsies, function enzymes, and clinical courses OLT were evaluated. Our results indicate that part...
Silicon is, besides oxygen, the most abundant element on earth. Only two taxa use this as a major constituent of their skeleton, namely sponges (phylum Porifera) and unicellular diatoms. Results from combined cytobiological molecularbiological techniques suggest that, in demosponge Suberites domuncula, silicic acid is taken up by transporter. Incubation cells with fluorescent silica tracer PDMPO [2-(4-pyridyl)-5-{[4-(2-dimethylaminoethylaminocarbamoyl)methoxy]phenyl}-oxazole] showed response...
It has been shown that inorganic monomeric and polymeric silica/silicate, in the presence of biomineralization cocktail, increases expression osteoprotegerin (OPG) osteogenic SaOS-2 sarcoma cells vitro. In contrast, silicate does not affect steady-state gene level osteoclastogenic ligand receptor activator NF-κB (RANKL). turn it can be expected concentration ratio mediators OPG/RANKL silicate. addition, enhances growth potential vitro, while causes no effect on RAW 264.7 within a range...
Silicateins are unique enzymes of sponges (phylum Porifera) that template and catalyze the polymerization nanoscale silicate to siliceous skeletal elements. These multifunctional spicules often elaborately shaped, with complex symmetries. They carry an axial proteinaceous filament, consisting silicatein scaffold protein silintaphin-1, which guides silica deposition subsequent spicular morphogenesis. In vivo, synthesis filament very likely proceeds in three steps: (a) assembly monomers form...
SUMMARY To date no nuclear receptors have been identified or cloned from the phylogenetically oldest metazoan phylum, Porifera (sponges). We show that retinoic acid causes tissue regression in intact individuals of demosponge Suberites domuncula and primmorphs, special three-dimensional cell aggregates. Primmorphs were cultivated on a galectin/poly-L-lysine matrix order to induce canal formation. In presence 1 50 μmol l–1 these canals undergo regression, process is reversible. also cDNA S....
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 165:247-257 (1998) - doi:10.3354/meps165247 Induction of gene expression chaperones 14-3-3 and HSP70 by PCB 118 (2,3',4,4',5-pentachlorobiphenyl) in marine sponge Geodia cydonium: novel biomarkers for polychlorinated biphenyls Matthias Wiens1, Claudia Koziol1, Hamdy M. A. Hassanein1, Renato Batel2, Heinz C....
Sponges (phylum Porifera) live in a symbiotic relationship with microorganisms, primarily bacteria. Until now, molecular proof for the capacity of sponges to recognize fungi surrounding aqueous milieu has not been available. Here we demonstrate, demosponge Suberites domuncula (Porifera, Demospongiae, Hadromerida), cell surface receptor that recognizes (1→3)‐β‐ d ‐glucans, e.g. curdlan or laminarin. This receptor, ‐glucan‐binding protein, was identified and its cDNA analysed. The gene coding...