A5101576018- Adipokines, Inflammation, and Metabolic Diseases
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Autophagy in Disease and Therapy
- Total Knee Arthroplasty Outcomes
- Spinal Cord Injury Research
- Hip disorders and treatments
- Knee injuries and reconstruction techniques
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Inflammation biomarkers and pathways
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
- Epigenetics and DNA Methylation
- Child Nutrition and Feeding Issues
- Attachment and Relationship Dynamics
- Hemostasis and retained surgical items
- Health and Medical Research Impacts
- Education Methods and Practices
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Medicinal Plants and Bioactive Compounds
- China's Socioeconomic Reforms and Governance
- Sirtuins and Resveratrol in Medicine
University of Groningen
2024
Renmin University of China
2024
China Three Gorges University
2021-2024
Yichang Central People's Hospital
2021-2024
Second Hospital of Yichang
2021-2024
Jilin University
2017-2024
Army Medical University
2024
First Hospital of Jilin University
2017-2024
Nanjing Medical University
2020-2023
Jiangsu Province Hospital
2020-2023
Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life patients. Due its etiology and pathogenesis was not studied equivocally yet, there currently a lack effective conservative treatments. Although they have been used for tissue repair, platelet-rich plasma-derived exosomes (PRP-Exo) disadvantage low retention short-lived therapeutic effects. This study aimed determine whether incorporation PRP-Exo in thermosensitive hydrogel...
Ischemia-reperfusion injury is the second most common of spinal cord and has risk neurological dysfunction paralysis, which can seriously affect patient quality life. Salidroside (Sal) an active ingredient extracted from Herba Cistanche with a variety biological attributes such as antioxidant, antiapoptotic, neuroprotective activities. Moreover, Sal shown protective effect in ischemia-reperfusion liver, heart, brain, but its not been elucidated. Here, we demonstrated for first time that...
Increasing evidence shows that metabolic factors are involved in the pathological process of osteoarthritis (OA). Lactate has been shown to contribute onset and progression diseases. While whether lactate is pathogenesis OA through impaired chondrocyte function its mechanism remains unclear. This study confirmed serum levels were elevated patients compared healthy controls positively correlated with synovial fluid levels, which also fasting blood glucose, high-density lipoprotein,...
Disruption of the blood-spinal cord barrier (BSCB) leads to inflammatory cell infiltration and neural death, thus, contributing poor functional recovery after spinal injury (SCI). Previous studies have suggested that Sirtuin 1 (SIRT1), an NAD+-dependent class III histone deacetylase, is abundantly expressed in endothelial cells promotes homeostasis. However, role SIRT1 BSCB function SCI remains poorly defined. Here, we report highly cells, its expression significantly decreases SCI. Using...
Abstract Background Researches have found that alteration of intestinal flora may be closely related to the development autism spectrum disorder (ASD). However, whether probiotics supplementation has a protective effect on ASD remains controversial. This meta-analysis aimed analyze outcome in treatment children. Methods The Pubmed, Cochrane Library, Web Science and Embase were searched until Sep 2022. Randomized controlled trials (RCTs) relevant placebo children screened. Quality assessment...
Spinal cord ischemia-reperfusion (IR) injury (SCIRI) is a significant secondary that causes damage to spinal neurons, leading the impairment of sensory and motor functions. Excessive reactive oxygen species (ROS) production considered one critical mechanism neuron in SCIRI. Nonetheless, molecular mechanisms underlying resistance neurons ROS remain elusive. Our study revealed deletion Git1 mice led poor recovery function after Furthermore, we discovered has beneficial effect on production....
Disgust helps humans avoid potentially pathogenic substances such as bodily effluvia. This reduces illness risks, and is difficult to overcome with cognitive strategies or even through simple habituation in the short term (minutes hours). Whether emerges long-term (months years) an unsolved question. Regular professional exposure disgust elicitors associated lower sensitivity avoidance, but this could be due selection survivorship bias. Here, we these limitations by testing a sample of...
Objective We aimed to describe the trends and influence factors in prevalence, awareness, treatment, control of hypertension among US Adults from 1999 2018. Methods utilized data National Health Nutrition Examination Survey (NHANES) spanning ten survey cycles (n = 53,496). Prevalence, were calculated using weights. Joinpoint regression survey-weighted generalized linear models used analyze factors, respectively. Results The estimated prevalence increased significantly 33.53% 40.58% (AAPC...
Background Oral anticoagulation (OAC) following catheter ablation (CA) of nonvalvular atrial fibrillation (NVAF) is essential for the prevention thrombosis events. Inappropriate application OACs does not benefit stroke but may be associated with a higher risk bleeding. Therefore, this study aims to develop clinical data-driven machine learning (ML) methods predict and bleeding establish more precise strategies patients NVAF. Methods Patients NVAF who underwent CA therapy were enrolled from...
How do natural disasters impact political trust in contemporary China and what is the causal mechanism? Existing literature indicates that severity of disaster, government relief effort information dissemination are three key factors influencing people’s context acute disasters. This study uses Wenchuan earthquake as a experiment focuses specifically on survey data collected right before after earthquake. It finds primarily due to ‘rally round flag’ effect extensive media coverage, public...
Purpose: This study was to evaluate the metabolic score for insulin resistance (METS-IR) in female knee osteoarthritis (KOA) patients a Chinese population. The associations between METS-IR and adipokines, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) were investigated. Patients Methods: included 4686 women from 2011 China Health Retirement Longitudinal Study (CHARLS) 108 who underwent arthroplasty of KOA at university hospital. clinical data collected, adipokines evaluated....
Objective: To evaluate the expression levels of adipokines in synovium and infrapatellar fat pad (IPFP) osteoarthritis (OA) patients with without metabolic syndrome (MetS).Methods: 120 female OA were enrolled, 60 healthy women matched body mass index, age, sex, served as controls. Adipokines measured using a sandwich enzyme-linked immunosorbent assay serum all participants synovial fluid (SF) patients. Local IPFP examined by immunohistochemical analysis. The amount adipokine proteins was...
The clearance of myelin debris is a critical step in the functional recovery following spinal cord injury (SCI). As phagocytes do, microvascular endothelial cells (MECs) participate at site within one week. Our group has verified that G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) essential autophagy and angiogenesis, both which are tightly related to uptake degradation by MECs. Here, we analyzed performance mechanism GIT1 after SCI. SCI contusion model was established
Abstract Rationale: Slipped capital femoral epiphysis (SCFE) is a common hip problem in adolescents, usually individuals between 8 and 15 years old. Because of the frequent finding growth abnormalities affected children, various endocrine disturbances have been reported as cause disease. However, there are few case reports older patients previous literature. To best our knowledge, congenital hypopituitarism with normal hormone (GH) level has not reported. Patient concerns: We describe...
Aims Morphological abnormalities are present in patients with developmental dysplasia of the hip (DDH). We studied and compared pelvic anatomy morphology between affected hemipelvis unaffected side unilateral Crowe type IV DDH using 3D imaging analysis. Methods A total 20 Crowe-IV were included study. The contralateral was considered normal all patients. coordinate system based on sacral base (SB) a reconstructed model established. orientations (tilt, rotation, obliquity) assessed by...
Orthogonal experiment was used to optimize the extraction conditions of Flammulina velutipes mycelia polysaccharides (FvP). Four independent variables (ratio water raw material, initial pH value, extracting temperature, and time) were taken into consideration. A yield FvP 2.19% obtained under an optimized condition material 50:1, value 6.0, temperature 85°C, time 6 h). Subsequently, antioxidative properties FvP-2 (crude polysaccharides) FvP-3 (deproteinized prepared from F. evaluated by...
Abstract Background The incidence of patient dissatisfaction due to anterior knee pain (AKP) and patellar crepitus after total arthroplasty (TKA) remains a concern. However, it has been shown that improvements in the femoral component traditional prostheses could reduce these instances case TKA performed with resurfacing. This study aims investigate whether without resurfacing can also benefit from aforementioned modification reducing AKP post-TKA. Methods Sixty-two patients (85 knees) who...
Whether using tissue adhesive alone after subcutaneous suture can close the skin incision with safety as well cosmetic appearance total hip arthroplasty was not clear.