A5016282865- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Spinal Cord Injury Research
- Intracranial Aneurysms: Treatment and Complications
- Advanced Cellulose Research Studies
- Vascular Procedures and Complications
- Reconstructive Surgery and Microvascular Techniques
- SARS-CoV-2 and COVID-19 Research
- Vascular Malformations Diagnosis and Treatment
- Extracellular vesicles in disease
- COVID-19 Impact on Reproduction
- Reconstructive Facial Surgery Techniques
- Congenital Heart Disease Studies
- Mosquito-borne diseases and control
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- RNA Interference and Gene Delivery
- Central Venous Catheters and Hemodialysis
- Legume Nitrogen Fixing Symbiosis
- Advanced Drug Delivery Systems
- Heart Failure Treatment and Management
- Peripheral Artery Disease Management
- Thyroid Cancer Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
Nanjing University
2024-2025
Nanjing General Hospital of Nanjing Military Command
2024-2025
Xuzhou Medical College
2022-2024
Jiangsu University
2008-2024
Jiangsu Academy of Agricultural Sciences
2019-2024
Wuxi People's Hospital
2024
Southeast University
2024
Yangzhou University
2024
Jiangsu Shengze Hospital
2020-2023
Nanjing Medical University
2020-2023
In China, large-scale outbreaks of severe diarrhea caused by viruses have occurred in pigs since late 2010. To investigate the prevalence and genetic evolution diarrhea-associated responsible for outbreaks, a total 2987 field diarrheal samples collected from 168 pig farms five provinces Southern China during 2012-2018 were tested.Porcine epidemic virus (PEDV) was most frequently detected with rates between 50.21 62.10% samples, 96.43% (162/168) premises, respectively. Porcine...
Abstract Background The distal transradial access (dTRA) has become an attractive and alternative to the conventional (TRA) for cardiovascular interventional diagnosis and/or treatment. There was a lack of randomized clinical trials evaluate effect dTRA on long-term radial artery occlusion (RAO). Methods This prospective, controlled study. primary endpoint incidence RAO at 3 months after discharge. secondary endpoints included successful puncture rate, time, other access-related...
Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse fetal outcomes. Several studies have indicated that ZIKV damage the brain directly; however, whether ZIKV-induced maternal placental injury contributes outcomes is sparsely defined. Here, we demonstrated causes pyroptosis of cells by activating executor gasdermin E (GSDME) in vitro and vivo. Mechanistically, TNF-α release induced upon recognition viral genomic RNA RIG-I, followed activation caspase-8...
The full-length genome sequence of a novel swine acute diarrhea syndrome coronavirus (SADS-CoV), CH/FJWT/2018, was determined, which genetically most closely related to CN/GDWT/2017, recently discovered in Fujian, China. indel sites the spike (S) gene CH/FJWT/2018 were similar those bat-origin SADS-related coronaviruses.
The COVID-19 pandemic continues to spread worldwide. To protect and control the of SARS-CoV-2, varieties subunit vaccines based on spike (S) proteins have been approved for human applications. Here, we report a new vaccine design strategy that functions as both an antigen carrier adjuvant in immunization elicit high-level immune responses. complex 2-hydroxypropyl-trimethylammonium chloride chitosan amylose entangles Au nanoparticles (HTCC/amylose/AuNPs) forming 40 nm nanocarriers with...
Abstract The blood-spinal cord barrier (BSCB) is a physical between the blood and spinal parenchyma. Current evidence suggests that disruption of BSCB integrity after injury can lead to secondary injuries such as edema excessive inflammatory response. Regulatory T (Treg) cells are effective anti-inflammatory inhibit neuroinflammation injury, their infiltration exhibits same temporal spatial characteristics automatic repair BSCB. However, few studies have assessed relationship Treg...
From 2010, porcine epidemic diarrhea virus (PEDV) variants caused sequential outbreaks of disease in Asia and the United States. In this retrospective study, 49 complete spike (S) gene sequences were obtained from PEDV strains collected China 2014 to 2016. We observed that variant with novel insertions, deletions, multiple S recombination types present China. addition, mixed infections involving different some areas. Based on phylogenetic analyses, we determined newly emerged potentially...
The clearance of myelin debris is a critical step in the functional recovery following spinal cord injury (SCI). As phagocytes do, microvascular endothelial cells (MECs) participate at site within one week. Our group has verified that G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) essential autophagy and angiogenesis, both which are tightly related to uptake degradation by MECs. Here, we analyzed performance mechanism GIT1 after SCI. SCI contusion model was established
BackgroundThere is a lack of randomized clinical trials on whether the 6-French (Fr) Glidesheath Slender (GSS; Terumo, Tokyo, Japan) superior to 6-Fr conventional radial sheath (CS) with respect early-term incidence distal artery occlusion (dRAO) in patients who have undergone coronary angiography (CAG) and/or percutaneous intervention (PCI) via transradial access.MethodsThis was prospective, single-centre trial were undergo CAG PCI either GSS or CS. The primary end point dRAO at 24 hours...
The study aimed to investigate the efficacy and safety of coronary intervention via distal transradial access (dTRA) in patients with low body mass index (BMI). A total 67 BMI who underwent intervention, comprising 29 dTRA 38 conventional (cTRA), were retrospectively included. There was no significant difference puncture success rate between two groups (dTRA 96.6%, cTRA 97.4%, P=0.846). Compared group, one-needle group lower (51.7% vs. 81.6%, P=0.020). compression haemostasis time shorter...
Abstract Background: In China, large-scale outbreaks of severe diarrhea caused by viruses have occurred in pigs since late 2010. To investigate the prevalence and genetic evolution diarrhea-associated responsible for outbreaks, a total 2,987 field diarrheal samples derived from 168 pig farms five provinces southern China were collected during 2012-2018 tested. Results: Porcine epidemic virus (PEDV) was mostly frequently detected with rates between 50.21% 62.10% samples, 96.43% (162/168)...
To investigate the clinical application of adjuvant coiling techniques in treating anterior-circulation wide-necked aneurysms.Over 4·5 years, 93 wide-neck aneurysms 81 patients were treated with different endovascular techniques: balloon-assisted, stent-assisted, and double-microcatheter coiling. Demographic, clinical, angiographic data reviewed retrospectively.Of aneurysms, 45 using stent, 28 balloon, 20 double microcatheter. The proportion ruptured was significantly lower stent group...
A carotid-jugular fistula is a direct communication between the carotid artery and jugular vein. Both congenital spontaneous internal carotid-jugulars are extremely rare. We describe first case of successful endovascular treatment for fistula. reported 64-year-old woman who presented with pulsatile mass swelling over left cervical region hemiplegia after cough. Digital subtraction angiography confirmed diagnosis high-flow The was successfully treated by fractional stent-assisted embolization.
Small cell neuroendocrine carcinoma (SCNEC) of the ureter is a rare tumour, accounting for less than 0.5% all ureteral tumours. SCNEC tumours are highly aggressive and patients have poor prognosis. Ureteral colliding with other pathological types extremely rare. In this paper, we present case patient small squamous review literature regarding clinicopathological features, treatment prognosis thus tumour. To best our knowledge, second identified SCC.A 64-year-old male presented history 1...