A5100417699- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Spinal Cord Injury Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Osteoarthritis Treatment and Mechanisms
- Peripheral Neuropathies and Disorders
- Cancer Immunotherapy and Biomarkers
- Spinal Dysraphism and Malformations
- Facial Rejuvenation and Surgery Techniques
- Extracellular vesicles in disease
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Imaging and Diagnostics
- Hereditary Neurological Disorders
- Cancer therapeutics and mechanisms
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- Facial Nerve Paralysis Treatment and Research
- Tuberous Sclerosis Complex Research
- Vagus Nerve Stimulation Research
- Cervical and Thoracic Myelopathy
- MicroRNA in disease regulation
- Enhanced Recovery After Surgery
- Infectious Encephalopathies and Encephalitis
Second Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Shaanxi University of Chinese Medicine
2023-2025
Hebei Eye Hospital
2024-2025
Nanjing Medical University
2023-2025
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
Jiujiang University
2025
Lanzhou University
2024
Hainan Medical University
2024
Ningxia Medical University
2024
Objective To examine the correlation between SIRI and probability of cardiovascular mortality as well all-cause in individuals with chronic kidney disease. Methods A cohort 3,262 participants from US National Health Nutrition Examination Survey (NHANES) database were included study. We categorized into five groups based on stage weighted Cox regression model was applied to assess relationship mortality. Subgroup analyses, Kaplan–Meier survival curves, ROC curves conducted. Additionally,...
Osteoarthritis (OA) is a multifaceted disease characterized by imbalances in extracellular matrix metabolism, chondrocyte and synoviocyte senescence, as well inflammatory responses mediated macrophages. Although there have been notable advancements pharmacological surgical interventions, achieving complete remission of OA remains formidable challenge, oftentimes accompanied significant side effects. Mesenchymal stem cells (MSCs) emerged promising avenue for treatment, given their ability to...
In recent times, it has been recognized that mesenchymal stem cells (MSCs) possess the capability to address osteoarthritis (OA). The objective of this research was examine impact injecting human adipose-derived (hADSCs) into a novel rabbit model with dual damage.
Background The current treatment strategy for metastatic Hormone-Sensitive Prostate Cancer (mHSPC) is the combination of Androgen Receptor Signaling Inhibitors (ARSIs) medicines with androgen deprivation therapy (ADT). However, there a lack real-world data comparing efficacy different ARSI pharmaceuticals. Therefore, objective this study was to compare effectiveness and safety bicalutamide, abiraterone, enzalutamide, apalutamide in ADT patients mHSPC. Methods We retrospectively analyzed 82...
Background: Chronic obstructive pulmonary disease (COPD) is characterized by and systemic inflammation. The peripheral blood (neutrophil + monocyte)/lymphocyte ratio (NMLR) can predict the clinical outcomes of several inflammatory diseases. However, its prognostic value in COPD remains unknown. Methods: This retrospective study included 870 patients with due to acute exacerbation, 5-year all-cause mortality these was recorded. Kaplan-Meier method used compare risk according their NMLR value....
Engineered extracellular vesicles play an increasingly important role in the treatment of spinal cord injury. In order to prepare more effective engineered vesicles, we biologically modified M2 microglia. Angiopep-2 (Ang2) is oligopeptide that can target blood–brain barrier. Through single-cell sequencing and immunofluorescence experiments, confirmed expression LRP-1, targeted receptor Ang2, was elevated after Subsequently, integrated Ang2 peptide segment into microglia obtain Ang2-EVs,...
Tuberculous pleural effusion (TPE) is a challenging extrapulmonary manifestation of tuberculosis, with traditional diagnostic methods often involving invasive surgery and being time-consuming. While various machine learning statistical models have been proposed for TPE diagnosis, these are typically limited by complexities in data processing difficulties feature integration. Therefore, this study aims to develop model using ChatGPT-4, large language (LLM), compare its performance logistic...
Background: Patients with diabetic liver injury are in the dilemma of lowering glucose and protecting function. This study aimed to uncover protective effect mechanism 1-deoxynojirimycin (1-DNJ), an alpha-glucosidase inhibitor, against injury. Methods: The db/db mice were gavaged 25 mg/kg, 50 100 mg/kg 1-DNJ for 8 weeks. At end administration, serum isolated further detection. biochemical indices including TC, TG, LDL-C, AST, ALT, TBiL detected serum. livers analyzed H&E, oil red, Masson...
Rationale: Blepharoptosis is a common disorder characterized by abnormal eyelid position that affects both visual function and esthetics. Postoperative upper retraction, which often due to overcorrection, major problem. Under normal circumstances, the operation usually performed on overcorrected eye. Here, we present case of patient who had previously undergone surgery correct right blepharoplasty, resulted in asymmetry. Utilizing Hering’s law, decided only left eye, resulting remarkable...
Abstract The blood-spinal cord barrier (BSCB) is a physical between the blood and spinal parenchyma. Current evidence suggests that disruption of BSCB integrity after injury can lead to secondary injuries such as edema excessive inflammatory response. Regulatory T (Treg) cells are effective anti-inflammatory inhibit neuroinflammation injury, their infiltration exhibits same temporal spatial characteristics automatic repair BSCB. However, few studies have assessed relationship Treg...
Background ALK-positive histiocytosis is an exceptionally rare neoplasm of histiocytes that predominantly involves the nervous system and can also affect skin other parts body. Previous relevant literature has provided limited information regarding imaging manifestations this disease with neurological involvement. Methods We reported a case multisystem Together comprehensive review, characteristics in were summarized. Results A 3-year-old girl abdominal pain ambulation difficulty checked at...
Objective Although several studies have examined the relationship between thyroid function and muscle strength, their population primarily derived from Asian areas, results were controversial. Thus, this study aimed to explore association handgrip strength (HGS) in U.S. population. Methods A total of 1,067 participants NHANES categorized into three different age groups including young (<45 years), middle (45~64 old (≥65 years) groups. Thyroid was measured by competitive binding...
Abstract Background Chronic obstructive pulmonary disease (COPD) is a globally prevalent respiratory disease, and programmed cell death plays pivotal role in the development of COPD. Disulfidptosis newly discovered type that may be associated with progression However, expression disulfidptosis‐related genes (DRGs) COPD remain unclear. Methods The DRGs was identified by analyzing RNA sequencing (RNA‐seq) data Further, patients were classified into two subtypes unsupervised cluster analysis to...
Abstract Cancer cells often exhibit defects in the execution of cell death, resulting poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form programmed death characterized by intracellular iron overload and lipid peroxidation membrane. Increasing evidence suggests that ferroptosis closely associated wide variety physiological pathological processes, particularly cancer. Notably, various bioactive natural products have been shown to induce...
Abstract Boosting anti-tumor immune responses can be achieved by activating the innate system. Despite ongoing development of numerous STING and TLR agonists for this purpose, none them have progressed to late-stage clinical evaluation. Alpha protein kinase-1 (ALPK1) is an intracellular receptor newly identified its ability detect ADP-heptose, a metabolite released during biosynthesis degradation lipopolysaccharides (LPS). Since heptose not naturally present in mammalian cells, recognition...
Abstract Aims This study aims to develop a scoring system for evaluating the degree of pulmonary vascular stenosis in fibrosing mediastinitis (FM). Methods and results A retrospective single-centre was conducted on 56 patients with FM China between April 2014 August 2021. The involvement vessels assessed using dual-phase computed tomography angiography, we found that 85.7% had both artery (PA) vein (PV) involvement. PA mainly located proximal upper bilateral basal trunk levels lower lungs....
A rapid screening test for urinary tract infections (UTIs) in children is needed to avoid unnecessary cultures and provide prompt reports make appropriate clinical decisions. We have evaluated the first time performance of Sysmex UF-5000 flow cytometer as a tool UTIs children.
Abstract Background Pulmonary fibrosis (PF) is a progressive and difficult-to-heal lung disease that poses significant threat to human life health. This study aimed investigate the potential pathological mechanisms of PF identify new avenues for treatment PF. Methods Clinical samples were collected assess effect disulfide-bond A oxidoreductase-like protein (DsbA-L) on TGF-β1-induced MLE-12 cell model bleomycin (BLM)-induced mice established. Changes in physiological morphology observed...