A5100625184- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer therapeutics and mechanisms
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Mycobacterium research and diagnosis
- Circular RNAs in diseases
Nanjing University of Information Science and Technology
2025
Second Hospital of Shandong University
2012-2025
Peking University Third Hospital
2014-2024
Zhongshan Hospital of Xiamen University
2024
Fudan University
2015-2024
Sun Yat-sen University
2015-2024
Peking University
2014-2024
Zhongshan Hospital
2015-2024
Affiliated Hospital of Guilin Medical College
2024
Chongqing Medical University
2014-2024
The signature composed of immune-related long noncoding ribonucleic acids (irlncRNAs) with no requirement specific expression level seems to be valuable in predicting the survival patients hepatocellular carcinoma (HCC). Here, we retrieved raw transcriptome data from Cancer Genome Atlas (TCGA), identified irlncRNAs by co-expression analysis, and recognized differently expressed irlncRNA (DEirlncRNA) pairs using univariate analysis. In addition, modified Lasso penalized regression. Then,...
Abstract Hepatocyte nuclear factor 3γ (HNF3γ) is a hepatocyte factor, but its role and clinical significance in hepatocellular carcinoma (HCC) remain unclear. Herein, we report that HNF3γ expression downregulated patient HCC inversely correlated with malignancy survival. Moreover, our data suggested the reduction could be mediated by METTL14-dependent m6A methylation of mRNA. was increased during hepatic differentiation decreased dedifferentiated cells. Interestingly, delivery promoted not...
Although cancer cells are frequently faced with a nutrient- and oxygen-poor microenvironment, elevated hexosamine-biosynthesis pathway (HBP) activity protein O-GlcNAcylation (a nutrient sensor) contribute to rapid growth of tumor emerging hallmarks cancer. Inhibiting could be promising anticancer strategy. The gluconeogenic enzyme phosphoenolpyruvate carboxykinase 1 (PCK1) is downregulated in hepatocellular carcinoma (HCC). However, little known about the potential role PCK1 enhanced HBP HCC...
Tumor-derived miRNAs in serum are emerging as the new noninvasive biomarkers for diagnosis of human cancers, especially at their early stage. An ideal method with high sensitivity, excellent selectivity, a simple procedure, and small amounts starting materials is imperative detection clinic circulating miRNAs. Here, we develop isothermally sensitive using hairpin probe-based rolling circle amplification (HP-RCA). This exhibits ultrahigh sensitivity toward lung cancer-related miR-486-5p limit...
Background Previous studies demonstrated that vagus nerve stimulation (VNS) is an effective therapy for drug-resistant epilepsy. Acupuncture also used to treat This study was designed examine the safety and effectiveness of transcutaneous auricular (ta-VNS) patients with Methods A total 50 volunteer epilepsy were selected a random clinical trial observe therapeutic effect ta-VNS. The seizure frequency, quality life, severity assessed in weeks 8, 16, 24 treatment according percentage...
We develop circular exponential amplification reaction (EXPAR)-based surface-enhanced Raman spectroscopy (SERS) for simultaneous sensitive detection of multiple microRNAs in non-small cell lung cancer cells. This method possesses distinct advantages excellent selectivity and high sensitivity with a limit as low 0.5 fM, which has improved by much 6 orders magnitude compared the previously reported SERS-based direct assay.
Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexpression of PCK1 has been shown to suppress liver growth, but underlying mechanism remains unclear. mRNA protein expression patterns PCK1, AMPK, pAMPK, CDK/Rb/E2F pathway were determined using qRT-PCR western blotting....
Abstract Solute carrier family 25 (SLC25) encodes transport proteins at the inner mitochondrial membrane and functions as carriers for metabolites. Although SLC25 genetic variants correlate with human metabolic diseases, their roles in colon cancer remain unknown. Cases of were retrieved from The Cancer Genome Atlas, transcriptionally differentially expressed members (DEMs) identified. DNA level alterations, clinicopathological characteristics, clinical survival also investigated. A risk...
9002 Background: Sunvozertinib(DZD9008) is a rationally designed selective, irreversible EGFR exon20 insertion (exon20ins) inhibitor with wild-type selectivity. Here we reported the results of WU-KONG6, first pivotal study sunvozertinib in previously treated NSCLC patients exon20ins. Methods: WU-KONG6 (NCT05712902 and CTR20211009) phase II, multi-center exon20ins, whose diseases had progressed on or were after platinum-based chemotherapy. Tumor tissue exon20ins status was tested by local...
Sensitive and accurate analysis of microRNA (miRNA) expression is imperative for understanding the biological functions miRNAs early diagnosis human cancers. Here, we develop a quencher-free fluorescent method homogeneously sensitive detection let-7a miRNA using target-triggered recycling signal amplification in combination with 2-aminopurine probe. The probe characterized by substitution adenine DNA strand quenching fluorescence through its stacking interaction adjacent bases. binding...
Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism. GSTZ1 dysregulated cancers; however, its role tumorigenesis and progression of hepatocellular carcinoma (HCC) largely unknown. We aimed to assess HCC reveal underlying mechanisms, which may contribute finding a potential therapeutic strategy against HCC.We first analyzed expression levels paired human adjacent normal tissue specimens prognostic effect on patients. Thereafter, we evaluated...
Gluconeogenesis, generates glucose from small carbohydrate substrates and drives the metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK-C), a rate-limiting enzyme gluconeogenesis, initiates gluconeogenesis process is reportedly dysregulated multiple types cancer. Gluconeogenesis mainly occurs liver during fasting, previous studies have demonstrated that PCK1 acts as tumor suppressor hepatocellular carcinoma...