A5020852276- Hernia repair and management
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Stoma care and complications
- COVID-19 epidemiological studies
- Ferroptosis and cancer prognosis
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Abdominal Surgery and Complications
- Colorectal Cancer Surgical Treatments
- Intestinal and Peritoneal Adhesions
- Liver Disease Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Gastroesophageal reflux and treatments
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Retinal Diseases and Treatments
- Glutathione Transferases and Polymorphisms
- Cancer, Lipids, and Metabolism
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Yunnan University
2012-2025
Second People's Hospital of Yunnan Province
2016-2025
Zhejiang University
2024
University of Pennsylvania
2015-2023
Hernia Center
2020-2022
Tianjin Medical University
2022
Key Laboratory of Guangdong Province
2020
Kunming Medical University
2018-2019
The Tibetan antelope (Pantholops hodgsonii) is endemic to the extremely inhospitable high-altitude environment of Qinghai-Tibetan Plateau, a region that has low partial pressure oxygen and high ultraviolet radiation. Here we generate draft genome this artiodactyl use it detect potential genetic bases highland adaptation. Compared with other plain-dwelling mammals, shows signals adaptive evolution gene-family expansion in genes associated energy metabolism transmission. Both American pika,...
Abstract Background Vascular endothelial growth factor (VEGF)-induced angiogenesis is a critical compensatory response to microvascular rarefaction in the diabetic retina that contributes proliferative retinopathy (PDR). In this study, we sought determine role of specific micro ribonucleic acids (RNAs) (miRs) associated with VEGF patients PDR pathology. Methods RNA sequencing was employed detect differentially circulating miR diabetes mellitus (DM), nonproliferative (NPDR) and PDR....
Hepatocellular carcinoma (HCC) has a dismal long-term outcome. We aimed to construct multi-gene model for prognosis prediction inform HCC management. The cancer-specific differentially expressed genes (DEGs) were identified using RNA-seq data of paired tumor and normal tissue. A prognostic signature was built by LASSO regression analysis. Gene get enrichment analysis (GSEA) performed further understand the underlying molecular mechanisms. 10-gene constructed stratify TCGA ICGC cohorts into...
Abstract SRY-box transcription factors (SOXs) are effective inducers for the formation of stem-like phenotypes. As a member SOX family, SOX9 (SRY-box factor 9) has been reported to be highly expressed and exert oncogenic functions in multiple human cancers. In this study, we hypothesized that could regulate function cancer stem/initiating cells (CSCs) further facilitate progression colorectal (CRC). Then, stable transfection shRNAs was used silence indicated genes. Loss-of-function...
Krüppel-like factor 5 (KLF5) takes part in the pathologic processes of many types cancer; however, its expression and roles biological behavior gastric cancer remain unknown. TargetScan suggested that miR-145-5p is predicted effective conserved microRNA (miRNA) binds to KLF5 through 3'-untranslated region (UTR). We investigated messenger RNA (mRNA) then analyzed role cells. Our results indicated was detected by immunohistochemistry 39.7% cases increased compared with corresponding...
Summary Circ RNA s exert gene regulatory effects by sequestering target micro (mi s) and play a vital role in the onset development of disease. Until recently, little has been known about expression, regulation biological function circ both health chronic hepatitis B ( CHB ).To identify hepatic associated with , we performed sequencing using liver biopsies from untreated patients controls. We then established bioinformatics pipeline for identification ‐associated silico analysis ‐mi ‐ mRNA...
CD4+ memory T cells are an important component of the tumor microenvironment (TME) and affect occurrence progression. Nevertheless, there has been no systematic analysis effect in gastric cancer (GC). Three datasets obtained from microarray corresponding clinical data GC patients were retrieved downloaded Gene Expression Omnibus (GEO) database. We uploaded normalize gene expression with standard annotation to CIBERSORT web portal for evaluating proportion immune samples. The WGCNA was...
To explore possible pathogenic genes for concomitant exotropia using whole-exome sequencing. In this study, 47 individuals from 10 (including intermittent and constant exotropia) pedigrees were enrolled. Whole-exome sequencing was used to screen mutational profiles in 25 affected unaffected individuals. Sanger silico analysis performed all participants. Two target capture the sequences of 220 sporadic samples. All presented autosomal dominant inheritance with childhood onset (3.35 ± 1.51...
Abstract Aberrant expression of musashi2 ( MSI ‐2) has been detected in several malignancies. However, its role the progression colorectal cancer CRC ) remains unknown. Our study was designed to investigate and prognostic significance ‐2 protein patients with cancer. The 164 patients’ control specimens by tissue microarray technique immunohistochemical staining. correlations between clinicopathological variables including overall survival were analyzed. value liver metastasis is evaluated...
Periodically updating COVID-19 vaccines that offer broad-spectrum protection is needed given the strong immune evasion by circulating omicron sublineages. The effectiveness of prototype and BA.4/5-containing bivalent mRNA reduced when XBB subvariants predominate. We initiated an observer-blinded, three-arms study in 376 patients Chinese individuals aged from 18 to 55 years old who had previously received three doses vaccine. Immunogenicity terms neutralizing antibodies elicited 30-μg dose...
Near-infrared (NIR) photothermal therapy plays a critical role in the cancer treatment and diagnosis as promising carcinoma modalities nowadays. However, development of clinical application has been greatly limited due to inefficient drug release low tumor accumulation. Herein, we designed NIR-light triggered indocyanine green (ICG)-based PCL core/P(MEO
Although the evolutionary changes of viral quasispecies are correlated to pathological status a disease, little is known in coexistence hepatitis B surface antigen (HBsAg) and antibodies these antigens (anti-HBs). To examine virus (HBV) their relationship HBsAg anti-HBs antibodies, HBV genomes patients with (experimental group) positive without (control were assessed. Our results showed that diversity was significantly higher experimental group for large (LHBsAg), middle (MHBsAg), genes....
Xihuang pill (XHP), a traditional Chinese herbal formula, has long been used as an effective agent against multiple tumors. The aim of this study is to evaluate the effects XHP on growth inhibition and apoptosis in glioblastoma U-87 MG cells. Gas chromatography-mass spectrometry (GC-MS) was performed for constituent analysis XHP. Cell viability, cell cycle arrest, generation reactive oxygen species (ROS), were measured by CCK-8 assay, PI/RNase staining, DCFH-DA TUNEL Annexin V-FITC/PI double...
Serum hepatitis B surface antigen (HBsAg) level has been developed as an important marker to predict treatment outcome recent years. The authors aimed identify the correlation between quantitative HBsAg and virus (HBV) DNA in chronic (CHB) patients explore whether can be used a surrogate of serum HBV for CHB patients. One hundred seventy‐three were included this study. Patients divided into two groups: Hepatitis e (HBeAg) positive negative There was HBeAg ( r = 0.509, P < 0.001) poor...
Background: The epidemiology and clinical outcome of gastroenteropancreatic signet ring cell carcinoma (SRC) were not well illustrated. We aimed to explore the long-term predictors affect overall survival (OS) patients with SRC in gastrointestinal tract pancreas. Methods: Annual age-adjusted incidence, OS trend evaluated Surveillance, Epidemiology, End Results (SEER) database from 2000 2014. Multivariate Cox hazards regression model used identify predictive factors entity disease. Results:...
Dysregulation of microRNA (miRNA) is actively involved in the development and progression gastric cancer (GC). MiR-520c was previously found to be overexpressed GC specimens cells. However, clinical significance miR-520c its biological function remain largely unknown. Here, we that expression tissues significantly increased compared normal adjacent tissues. Its level prominently correlated with poor parameters prognosis patients. Accordingly, obviously elevated cell lines as epithelial...