A5100607296- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Prenatal Screening and Diagnostics
- Cancer Genomics and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Cells and Metastasis
- Genomic variations and chromosomal abnormalities
- Cell Adhesion Molecules Research
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
Linyi People's Hospital
2020
Qingdao University
2020
Qingdao Municipal Hospital
2020
Fujian Provincial Cancer Hospital
2020
Fujian Medical University
2020
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2019
Sun Yat-sen University
2015-2019
Hainan Maternal and Child Health Hospital
2017
Hainan Medical University
2017
Changchun 208 Hospital
2008
Down-regulation of the miRNA miR-338-3p correlates with invasive ability hepatocellular carcinoma (HCC) cells. However, it is currently unclear whether down-regulation induces epithelial-mesenchymal transition (EMT), which may be underlying mechanism governing HCC invasion. Here, we demonstrate that restoration expression via transfection a mimic reversed EMT and inhibited motility invasiveness Conversely, silencing endogenous miR-338-3p-specific inhibitor induced enhanced cell motility....
Recently, microRNA-96-5p (miR-96-5p) has been reported to function as both a tumor suppressor and oncogene in several cancer types, including gastric cancer, hepatocellular lung cancer. However, the biological of miR-96-5p its precise mechanisms oral squamous cell carcinoma (OSCC) have not well clarified. The aim this study was roles miR-96-5p/FOXF2 axis OSCC. In study, level dramatically enhanced OSCC tissues lines, FOXF2 expression significantly reduced. addition, negatively related...
Dysregulation of microRNA (miRNA) is actively involved in the development and progression gastric cancer (GC). MiR-520c was previously found to be overexpressed GC specimens cells. However, clinical significance miR-520c its biological function remain largely unknown. Here, we that expression tissues significantly increased compared normal adjacent tissues. Its level prominently correlated with poor parameters prognosis patients. Accordingly, obviously elevated cell lines as epithelial...
Emerging studies have indicated that the dysregulation of microRNAs (miRNAs or miRs) plays a vital role in development and metastasis tumors. However, miR‑93‑5p esophageal carcinoma (EC) has not been extensively reported. The present study thus focused on its downstream target occurrence EC. Firstly, miRNA expression profiles associated with EC were accessed from TCGA_ESCA dataset analyzed. Subsequently, patterns TGFβR2 characterized human cell line, Het‑1A, lines, TE‑1, Eca‑109 EC9706, by...
Long non-coding RNA (lncRNA) exerts a regulatory role in the occurrence and progression of tumors. This study aimed at probing into function mechanism lncRNA DICER1 antisense 1 (DICER1-AS1) colorectal cancer (CRC).The expressions DICER1-AS1, miR-296-5p STAT3 mRNA were tested by quantitative real-time polymerase chain reaction (qRT-PCR). Cell counting kit-8 (CCK-8) assay was employed to detect cell proliferation, Transwell used migration invasion. In addition, apoptosis-related proteins Bax...
Long non-coding (lnc)RNA mortal obligate RNA transcript (MORT) is inhibited in numerous types of cancer humans, indicating its role as a tumor suppressor. The present study demonstrated downregulation lncRNA MORT the tissues patients with colon cancer. expression was linearly associated levels plasma. Low low overall survival rate. Moreover, overexpression resulted decreased, whereas treatment transforming growth factor β1 (TGF-β1) increased, invasion and migration rates cells. In addition,...
Objective To construct the recombinant adenovirus vector with human gene TGF-β1 (shRNA,short hairpin RNA)by Cre/lox P system.Methods Human U6 promoters following shRNA(U6shTGF-β1)were obtained PCR.Then were ligated to T-vector.After plasmids pT-U6shTGF-β1 being formed.these transformed into E.coli JM109.The target fragment was subcloned a shuttle plasmid PDC316 PDC3 16-TGF-β1.Then combinant and genomic pBHGlox△E1 3Cre cotransfected 293T cell AdTGF-β1,which then identified by infection test...