A5076826904- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Hip disorders and treatments
- Bone health and treatments
- MicroRNA in disease regulation
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Estrogen and related hormone effects
- Bone health and osteoporosis research
- Iron Metabolism and Disorders
- Virus-based gene therapy research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Molecular Sensors and Ion Detection
- Pelvic and Acetabular Injuries
- Acute Ischemic Stroke Management
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Trace Elements in Health
- Barrier Structure and Function Studies
Third Xiangya Hospital
2025
Central South University
2025
Affiliated Zhongshan Hospital of Dalian University
2015-2025
Guangzhou University of Chinese Medicine
2017-2025
Dezhou University
2020-2025
Chinese Academy of Sciences
2006-2025
Institute of Subtropical Agriculture
2025
Guangxi University
2025
Soochow University
2016-2024
Second Affiliated Hospital of Soochow University
2016-2024
Nontraumatic osteonecrosis of the femoral head (NONFH) is a debilitating disease that represents significant financial burden for both individuals and healthcare systems. Despite its significance, however, prevalence in Chinese general population remains unknown. This study aimed to investigate NONFH associated risk factors population.A nationally representative survey 30,030 respondents was undertaken from June 2012 August 2013. All participants underwent questionnaire investigation,...
Abstract Carbon nanotubes (CNTs) have unique chemical and physical properties anticipated to enable broad novel biomedical applications. Yet the question concerning their biocompatibility remains controversial. We recently reported a method for rapidly preparing strong, highly electrically conducting sheets yarns from multi-walled CNTs. The present studies demonstrate that oriented 50-nm-thick semi-transparent CNT yarns, produced with minimal residual content of catalytic transition...
Steroid-induced osteonecrosis of the femoral head (SONFH) is a refractory disease induced by glucocorticoids. Marrow mesenchymal stem cells (MSCs) differentiate into multiple bone matrix and have been used as cell-based therapies to treat ONFH. However, osteogenesis MSCs isolated from patients with SONFH significantly decreased. Polydatin has widely in traditional Chinese remedies due its pharmacological actions. As shown our previous study, protects oxidative stress promotes BMSC migration....
We determined the safety and efficacy of coadministration CD19- CD22-chimeric antigen receptor (CAR) T cells in patients with refractory disease or high-risk hematologic isolated extramedullary relapse B-acute lymphoblastic leukemia.
The burden of gastric cancer (GC) across different age groups needs updating. We determined the GC global, regional, and national profiles changes in incidence for 3 sequential 5-year intervals from 2003 to 2017.
Background/Aims: Bone marrow-derived mesenchymal stem cells (BMSCs) have the ability to differentiate into multilineage such as osteoblasts, chondrocytes, and cardiomyocytes. Dysfunction of BMSCs in response pathological stimuli participates development diseases osteoporosis. Astragalus polysaccharide (APS) is a major active ingredient membranaceus, commonly used anti-aging herb traditional Chinese medicine. The aim this study was investigate whether APS protects against iron...
Rationale: Increased lipid droplet (LD) formation has been linked to tumor metastasis, stemness, and chemoresistance in various types of cancer. Here, we revealed that LD is critical for the adaptation sorafenib hepatocellular carcinoma (HCC) cells. We aim investigate function its regulatory mechanisms HCC. Methods: The key proteins responsible were screened by both metabolomics proteomics sorafenib-resistant HCC cells further validated immunoblotting immunofluorescence staining. Biological...
Pericytes are known to regulate brain capillary endothelial functions. The purpose of this study was define the hemostatic regulatory role human pericytes. We used blood–brain barrier models consisting pericytes grown on transwell membrane inserts and cocultured with microvascular cells (HBEC), or in direct contact HBEC. When cocultures which were physically separated from cells, induced significant changes tissue plasminogen activator (tPA) messenger ribonucleic acid (mRNA) protein: tPA...
Osterix (Osx) is an osteoblast-specific transcription factor required for bone formation and osteoblast differentiation. The critical step in to replace the avascular cartilage template with vascularized bone. Osteogenesis angiogenesis are associated each other, sharing some essential regulators. Vascular endothelial growth (VEGF) involved both osteogenesis. Transcriptional regulation of VEGF expression not well known osteoblasts. In this study, quantitative real-time RT-PCR results revealed...
Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism. GSTZ1 dysregulated cancers; however, its role tumorigenesis and progression of hepatocellular carcinoma (HCC) largely unknown. We aimed to assess HCC reveal underlying mechanisms, which may contribute finding a potential therapeutic strategy against HCC.We first analyzed expression levels paired human adjacent normal tissue specimens prognostic effect on patients. Thereafter, we evaluated...
The development of radioresistance remains the obstacle for prostate cancer (PCa) treatment. Here, we explored role and potential mechanism circular RNA zinc finger protein 609 (circ-ZNF609) in PCa cells. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect expression circ-ZNF609, microRNA-501-3p (miR-501-3p) hexokinase 2 (HK2) messenger (mRNA). viability, apoptosis, metastasis cells were assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...
Article28 June 2019Open Access Source DataTransparent process GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone Fan Yang Key Laboratory Molecular Biology for Infectious Diseases (Ministry Education), Department Diseases, The Second Affiliated Hospital, Institute Viral Hepatitis, Chongqing Medical University, Chongqing, China First Search more papers by this author Jingjing Li Haijun Deng Yihao Wang State Proteomics, Beijing Proteome...
As a necessary trace element, iron is involved in many physiological processes. Clinical and basic studies have found that disturbances metabolism, especially overload, might lead to bone loss even be postmenopausal osteoporosis. Hepcidin key regulator of homeostasis. However, the exact role hepcidin metabolism underlying mechanism remain unknown. In this study, we osteoporosis cohort, concentration serum was significantly reduced positively correlated with mineral density. Ovariectomized...
Summary Although chimeric antigen receptor T cells (CAR‐T) targeted at CD19 or CD22 have achieved high complete remission (CR) in refractory/relapsed B‐cell acute lymphoblastic leukaemia (B‐ALL), it is uncertain if allogeneic haematopoietic stem cell transplantation (allo‐HSCT) should be performed after CAR‐T therapy to accomplish a sustainable remission. Fifty‐two cases with relapsed/refractory B‐ALL who underwent allo‐HSCT CR by were enrolled. The median time from infusion was 50 (34–98)...
Glucocorticoid-induced osteoporosis (GIOP) is a serious clinical bone disease that results from the long-term consumption of glucocorticoids or glucocorticoid-like drugs. Although many studies have attempted to determine mechanisms GIOP, they are still unclear. In this study, we established zebrafish model drug-induced by treating larvae with prednisolone. We then quantified expression selection extracellular matrix (ECM)-, osteoblast-, and osteoclast-related genes. Our showed at 15 days...
Abstract Background Neonatal bacterial meningitis is a common neonatal disease with high morbidity, and can cause serious sequelae when left untreated. Escherichia coli the pathogen, its endotoxin, lipopolysaccharide (LPS) damage endothelial cells, increasing permeability of blood-brain barrier (BBB), leading to intracranial inflammation. However, specific mechanism induced by LPS damaging BBB remains unclear. In this study, mouse brain microvascular (bEND.3) cells were used as research...