A5056044419- Bone Metabolism and Diseases
- Bone health and treatments
- NF-κB Signaling Pathways
- Orthopaedic implants and arthroplasty
- Bone health and osteoporosis research
- Neurobiology and Insect Physiology Research
- Cell Adhesion Molecules Research
- Estrogen and related hormone effects
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Shoulder Injury and Treatment
- Immunotoxicology and immune responses
- Signaling Pathways in Disease
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Aquaculture Nutrition and Growth
- Shoulder and Clavicle Injuries
- S100 Proteins and Annexins
- Advanced Radiotherapy Techniques
- Cytokine Signaling Pathways and Interactions
- TGF-β signaling in diseases
- Breast Cancer Treatment Studies
- Reproductive biology and impacts on aquatic species
- Pharmacological Effects of Medicinal Plants
The University of Western Australia
2016-2025
Chinese University of Hong Kong
2025
University of Hong Kong
2025
Chengdu University of Traditional Chinese Medicine
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Xiamen University
2018-2021
Southwest Medical University
2021
Weatherford College
2020
Versus Arthritis
2020
State Key Laboratory of Marine Environmental Science
2018-2019
ABSTRACT Excessive osteoclast (OC) activity together with relatively weak osteoblast (OB) function are strongly connected to osteolytic diseases, including osteoporosis, tumor-induced osteolysis, and inflammatory bone erosion. Very few natural products or compounds have been shown exert therapeutic effects on both OCs OBs, limiting the potential development of for clinical application. Hymenialdisine (HMD) is a marine sponge–derived inhibitor protein kinases previously reported...
Bone undergoes life-long remodelling, in which disorders of bone remodelling could occur many pathological conditions including osteoporosis. Understanding the cellular metabolism osteoclasts is key to developing new treatments for osteoporosis, a disease that affects over 200 million women worldwide per annum. We found human osteoclast differentiation from peripheral blood mononuclear cells (PBMCs) derived 8 female patients featured with distinct gene expression profile mitochondrial...
Drug-induced osteotoxicity refers to the harmful effects certain drugs have on skeletal system, posing significant safety risks. These toxic are a key concern in clinical practice, drug development, and environmental management. However, existing toxicity assessment models lack specialized data sets algorithms for predicting osteotoxicity. In our study, we collected osteotoxic molecules employed various large language models, including DeepSeek ChatGPT, alongside traditional machine learning...
Osteoporosis is a metabolic disease characterized by osteopenia and bone microstructural deterioration. Osteoclasts are the primary effector cells that degrade matrix their abnormal function leads to development of osteoporosis. Reactive oxygen species (ROS) accumulation during cellular metabolism promotes osteoclast proliferation differentiation, therefore, playing an important role in Cistanche deserticola polysaccharide (CDP) possesses antitumor, anti‐inflammatory, antioxidant activity....
Osteoporosis, which typically affects postmenopausal women, is an osteolytic disease due to over-activation of osteoclasts. However, current drugs targeting osteoclast inhibition face various side effects, making natural compounds with great interest as alternative treatment options. Cycloastragenol (CAG) a triterpenoid multiple biological activities. Previously, CAG's activity against aging-related osteoporosis was reported, but the mechanisms actions for activities were not understood....
Osteoclasts are highly differentiated multinucleated giant cells that play fundamental roles in bone resorption and the pathogenesis of osteolytic conditions, such as osteoporosis cancer-induced loss. Achyranthes bidentata polysaccharide (ABP) is a hydrophilic compound with anti-oxidation anti-aging characteristics. The impact ABP on RANKL-induced osteoclast formation has not been assessed, hence, this study we investigated effect murine marrow derived osteoclasts. We found was able to...
Abstract Osteolysis is a common medical condition characterized by excessive activity of osteoclasts and bone resorption, leading to severe poor quality life. It essential identify the medications that can effectively suppress differentiation function prevent reduce osteolytic conditions. has been reported Carnosol (Car), isolated from rosemary salvia, anti‐inflammatory, antioxidative, anticancer effects, but its on osteolysis not determined. In this study, we found Car strong inhibitory...
Abstract Osteoporosis is the most common osteolytic disease characterized by excessive osteoclast formation and resultant bone loss, which afflicts millions of patients around world. Astilbin, a traditional herb, known to have anti‐inflammatory, antioxidant antihepatic properties, but its role in osteoporosis treatment has not yet been confirmed. In our study, astilbin was found an inhibitory effect on RANKL‐induced function OCs dose‐dependent manner without cytotoxicity. These effects were...
Toll-like receptors (TLRs) are major molecular pattern recognition receptors, which essential for triggering a series of innate immune responses against invading pathogens by recognizing their evolutionary conserved patterns. The mudskipper, Boleophthalmus pectinirostris is exceptional among fishes due to its amphibious lifestyle and adaptation living on mudflats. whole-genome sequencing B. has revealed that this species possesses an expansion Tlr11 family (12 genes (one tlr21, 4 tlr22 7...
The tumor necrosis factor (TNF)-like core domain of receptor activator nuclear factor-κB ligand (RANKL) is a functional critical for osteoclast differentiation. One the missense mutations identified in patients with osteoclast-poor autosomal recessive osteopetrosis (ARO) located residue methionine 199 that replaced lysine (M199K) amid TNF-like domain. However, structure-function relationship this mutation not clear. Sequence-based alignment revealed fragment containing human M199 highly...
Postmenopausal osteoporosis (PMO) is a progressive disease occurring in elderly postmenopausal women that characterized by low bone mass and impaired quality.
Abstract Imbalance of osteoblast and osteoclast in adult leads to a variety bone‐related diseases, including osteoporosis. Thus, suppressing the activity osteoclastic bone resorption becomes main therapeutic strategy for Asperpyrone A is natural compound isolated from Aspergillus niger with various biological activities antitumour, antimicrobial antioxidant. The present study was designed investigate effects on osteoclastogenesis explore its underlining mechanism. We found that inhibited...
Abstract Calmodulin is a highly versatile protein that regulates intracellular calcium homeostasis and involved in variety of cellular functions including cardiac excitability, synaptic plasticity signaling transduction. During osteoclastic bone resorption, calmodulin has been reported to concentrate at the ruffled border membrane osteoclasts where it thought modulate resorption activity response calcium. Here we report an interaction between Rab3D, small exocytic GTPase established...