A5013113490- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Advanced MRI Techniques and Applications
- Gastrointestinal motility and disorders
- Botulinum Toxin and Related Neurological Disorders
- Dental Radiography and Imaging
- Cleft Lip and Palate Research
- Peroxisome Proliferator-Activated Receptors
- Dental Implant Techniques and Outcomes
- Neurological diseases and metabolism
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Catalysts for Methane Reforming
- Acute Ischemic Stroke Management
- Nuclear Receptors and Signaling
- Intracranial Aneurysms: Treatment and Complications
- Nutrition, Health and Food Behavior
- Cerebrovascular and Carotid Artery Diseases
- Temporomandibular Joint Disorders
Lanzhou University
2025
Second Affiliated Hospital of Zhejiang University
2019-2024
Peking University Shenzhen Hospital
2004-2024
Zhejiang University
2022-2024
Wenzhou Medical University
2018-2024
First Affiliated Hospital of Wenzhou Medical University
2018-2024
Jining First People's Hospital
2023
McMaster University
2019-2022
University of South China
2017-2019
Zhongshan Hospital
2017-2019
Alpha-synucleinopathy is postulated to be central both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein glymphatic system dysfunction. However, accumulating primarily based on clinical data support dysfunction in patients with iRBD PD currently insufficient. This study aimed use diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate...
Abstract Increasing evidence suggests that Parkinson’s disease (PD) exhibits disparate spatial and temporal patterns of progression. Here we used a machine-learning technique—Subtype Stage Inference (SuStaIn) — to uncover PD subtypes with distinct trajectories clinical neurodegeneration events. We enrolled 228 patients 119 healthy controls comprehensive assessments olfactory, autonomic, cognitive, sleep, emotional function. The integrity substantia nigra (SN), locus coeruleus (LC), amygdala,...
Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated wound healing. Melatonin, a major secretory product of the pineal gland, promotes healing; however, its mechanism action remains unclear. Here, EPCs were isolated from bone marrow mice. Treatment with melatonin alleviated advanced glycation end (AGE)-induced cellular dysfunction. We further examined autophagy flux after treatment found increased light chain 3...
Abstract Brain structural changes in Parkinson’s disease (PD) are progressive throughout the course. Changes surface morphology with progression remain unclear. This study aimed to assess volumetric and shape of subcortical nuclei during explore their association clinical symptoms. Thirty-four patients 32 healthy controls were enrolled. The global volume compared between at baseline. also explored baseline 2 years follow-up. Association analysis was performed structures In PD, there...
Neurotrophin-3 (NT-3) plays numerous important roles in the CNS and elevation of intracellular Ca(2+) ([Ca(2+)](i)) is critical for these functions NT-3. However, mechanism by which NT-3 induces [Ca(2+)](i) remains largely unknown. Here, we found that transient receptor potential canonical (TRPC) 5 protein TrkC, receptor, exhibited a similar temporal expression rat hippocampus cellular colocalization hippocampal neurons. Stimulation neurons induced nonselective cation conductance...
Abstract Aims To detect functional connectomes of akinetic‐rigid (AR) and tremor compare their connection pattern. Methods Resting‐state MRI data 78 drug‐naïve PD patients were enrolled to construct AR via connectome‐based predictive modeling (CPM). The further validated with 17 verify replication. Results related identified CPM method successfully in the independent set. Additional regional‐based demonstrated neither nor could be simplified changes within a single brain region....
Background: Hyperlipidemia is a risk factor for neurodegenerative diseases. Proprotein convertase subtilisin / Kexin type 9 (PCSK9) degrades hepatic low-density lipoprotein receptor (LDLR) to regulate lipid metabolism. It unclear if PCSK9 plays role in Objective: This study was designed determine whether crucial between hyperlipidemia and Alzheimer’s disease. The interrelationship neuronal apoptosis explored PC12 cells response treatment with oxidized (oxLDL). Methods: Cultured were...
Abstract Background Dysfunction of iron metabolism, especially in substantia nigra (SN), is widely acknowledged Parkinson's disease (PD), but the genetic influence on deposition remains largely unknown. Thus, this study, we aimed to investigate potential impacts PD. Methods Seventy‐four subjects, including 38 patients with PD and 36 age‐matched normal controls, participated study. Imaging association analysis was used identify specific single nucleotide polymorphism (SNP) iron‐related...
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays important roles in the cardiovascular system. In our previous studies, we demonstrated H2S regulates lipid metabolism. present study, aimed to explore mechanisms through which metabolism HepG2 cells vitro. Treatment of with inhibited expression proprotein convertase subtilisin/kexin type 9 (PCSK9) and increased level low‑density lipoprotein receptor (LDLR) a time‑ dose‑dependent manner. The knockdown PCSK9 by siRNA...
Degeneration of the locus coeruleus (LC) is recognized as a critical hallmark Parkinson's disease (PD). Recent studies have reported that noradrenaline produced from LC has effects on brain functional organization. However, it unknown if degeneration in PD contributes to cognitive/motor manifestations through modulating This study enrolled 94 patients and 68 healthy controls, integrity was measured using contrast-to-noise ratio (CNRLC) calculated T1-weighted magnetic resonance imaging. We...
Parkinson's disease (PD) is highly heterogeneous reflected by different affected side of body and type motor symptom. We aim to explore clinical characteristics underlying brain structure alterations in PD with predominant sides types.We recruited 161 patients 50 healthy controls (HC). Patients were classified into four subtypes according their type: left akinetic/rigid-dominant (LAR), tremor-dominant (LTD), right (RAR), (RTD). All participants assessed cognitive performances, then underwent...
Postmenopausal osteoporosis (PMO) is a progressive disease occurring in elderly postmenopausal women that characterized by low bone mass and impaired quality.
Parkinson's disease (PD) is commonly characterized by asymmetrical motor impairment. This study aimed to clarify the iron distributions in PD patients with significant asymmetry and their longitudinal alterations. included 123 121 normal controls. Thirty-eight were revisited. identified using an objective criterion. Inter-group, inter-hemisphere inter-visit differences of regional tissue susceptibility analyzed. Iron accumulation dominantly non-dominantly affected substantia nigra (SN)...
3D high-resolution vessel wall imaging is increasingly used for intracranial arterial diseases. This study compared the diagnostic performance of black-blood luminal angiography derived from with source images and TOF-MRA in detecting middle cerebral artery stenosis.Sixty-two patients suspected MCA atherosclerosis underwent TOF-MRA, imaging, CTA. Intracranial was created using minimum intensity projection. The degree length stenosis were measured on CTA as a reference standard.The image...
The widely divergent responsiveness of Parkinson's disease (PD) patients to levodopa is an important clinical issue because its relationship with quality life and prognosis. Preliminary animal experiments have suggested that degeneration the locus coeruleus (LC) attenuates efficacy treatment.To explore between LC in PD vivo.Neuromelanin-sensitive magnetic resonance imaging (NM-MRI), a good indicator substantia nigra (SN) degeneration, challenge tests were conducted 57 patients....
Background Excessive iron accumulation is one of the main pathogeneses Parkinson's disease (PD). Ceruloplasmin plays an important role in keeping homoeostasis. Purpose To explore association between serum ceruloplasmin depletion and subcortical distribution PD. Study type Prospective. Population One hundred twenty‐one normal controls, 34 PD patients with low (PD‐LC), 28 (PD‐NC). Sequence Enhanced susceptibility‐weighted angiography (ESWAN) on a 3 T scanner. Assessment Quantitative...
Background: In Parkinson’s disease (PD), excessive iron deposition in the substantia nigra may exacerbate α-synuclein aggregation, facilitating degeneration of dopaminergic neurons and their neural projection. Objective: To investigate interaction effect between nigral PD status on brain networks. Methods: Eighty-five patients 140 normal controls (NC) were included. Network function measured using multi-modality magnetic resonance imaging. According to median susceptibility NC (0.095 ppm),...