A5101562728- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological diseases and metabolism
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Connective tissue disorders research
- Glioma Diagnosis and Treatment
- Neurological and metabolic disorders
- Testicular diseases and treatments
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Ginkgo biloba and Cashew Applications
- Ferroptosis and cancer prognosis
Second Affiliated Hospital of Zhejiang University
2016-2024
Zhejiang University
2019-2023
Hangzhou First People's Hospital
2019-2020
Alfred I. duPont Hospital for Children
2008
Nemours Children’s Clinic
2004-2006
Dupont Hospital
2004-2006
Nemours Children's Clinic
2006
DuPont (United States)
2004
Children's Hospital of Philadelphia
2004
Hershey (United States)
2004
Alpha-synucleinopathy is postulated to be central both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson's disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein glymphatic system dysfunction. However, accumulating primarily based on clinical data support dysfunction in patients with iRBD PD currently insufficient. This study aimed use diffusion tensor image analysis along perivascular space (DTI-ALPS) evaluate...
The glymphatic system offers a perivascular pathway for the clearance of pathological proteins and metabolites to optimize neurological functions. Glymphatic dysfunction plays pathogenic role in Parkinson's disease (PD); however, molecular mechanism PD remains elusive. To explore whether matrix metalloproteinase-9 (MMP-9)-mediated β-dystroglycan (β-DG) cleavage is involved regulation aquaporin-4 (AQP4) polarity-mediated PD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced A53T...
Aquaporin-4 (AQP4) facilitates a sleep-enhanced interstitial brain waste clearance system. This study was conducted to determine the clinical implication of AQP4 polymorphisms in Parkinson's disease (PD).Three-hundred and eighty-two patients with PD 180 healthy controls mean follow-up time 66.1 months from Progression Marker Initiative were analyzed. We examined whether SNPs associated an altered rate motor or cognitive decline using linear mixed model Cox regression. then investigated Aβ...
JOURNAL/nrgr/04.03/01300535-202507000-00026/figure1/v/2024-09-09T124005Z/r/image-tiff Parkinson’s disease is primarily caused by the loss of dopaminergic neurons in substantia nigra compacta. Ferroptosis, a novel form regulated cell death characterized iron accumulation and lipid peroxidation, plays vital role neurons. However, molecular mechanisms underlying ferroptosis have not yet been completely elucidated. NADPH oxidase 4 related to oxidative stress, however, whether it regulates...
Background Despite the importance of clinical heterogeneity in Parkinson’s disease (PD), its underlying pathophysiology remains unclear. Objective This study aimed to distinguish association free-water (FW) imaging data for cholinergic nuclei with motor subtypes PD. Methods The included 150 cases idiopathic PD from Progression Markers Initiative cohort. FW imaging, including FW-corrected diffusion tensor was used extract structural metrics nucleus 4 (Ch4) basal forebrain and pedunculopontine...
ABSTRACT Background Emerging evidence indicates that the apolipoprotein E ( APOE ) ε4 exacerbates α‐synuclein pathology. Objective To determine whether contributes to motor progression in early Parkinson's disease (PD). Methods Longitudinal data were obtained from 384 patients with PD divided into carriers n = 85) and noncarriers 299) Progression Marker Initiative. Participants underwent yearly assessments over a mean follow‐up period of 78.9 months. Repeated measures linear mixed models...
Abstract Background and purpose The insidious onset of Parkinson's disease (PD) makes early diagnosis difficult. Notably, idiopathic rapid eye movement sleep behavior disorder (iRBD) was reported as a prodrome PD, which may represent breakthrough for the PD. However, currently there is no reliable biomarker PD diagnosis. Considering that α‐synuclein (α‐Syn) neuroinflammation are known to develop prior clinical symptoms in it hypothesized plasma total exosomal α‐Syn (t‐exo α‐Syn),...
Dysfunction of the glymphatic system, an intracranial clearance pathway that drains misfolded proteins, has been implicated in onset Parkinson’s disease (PD). Recently, coupling strength global blood-oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow dynamics have suggested to be indicator function. Using resting-state functional magnetic resonance imaging (MRI), we quantified gBOLD–CSF as cross-correlation between baseline gBOLD CSF evaluate function its association...
Abstract Background We previously identified a significant association between Aquaporin‐4 ( AQP4 ) and Parkinson's disease (PD). Objectives To identify whether single‐nucleotide polymorphism (SNP) rs162009 affects regional brain activity clinical phenotypes of PD. Methods Low‐frequency fluctuation amplitude (ALFF) was used to evaluate spontaneous activity, homogeneity (ReHo) the pace adjacent voxel regions, degree centrality (DC) describe functional connection strength whole brain. Disease...
Background: Excessive aggregation of α-synuclein is the key pathophysiological feature Parkinson's disease (PD). Rapid eye movement sleep behavior disorder (RBD) also associated with synucleinopathies and considered as a powerful predictor PD. Growing evidence suggests diminished clearance may be partly attributable to poor interstitial fluid drainage, which can reflected by magnetic resonance imaging (MRI)-visible enlarged perivascular space (EPVS). However, effect MRI-visible EPVS on iRBD...
Testosterone and luteinizing hormone secretion is reportedly impaired in infants born with cryptorchidism. To better characterize this phenomenon, we studied a range of hormones that normally increase boys during the first few months life.A case-control study was conducted nonsyndromic cryptorchidism identified at birth (cases) descended testes presenting to urology clinic without endocrine related concerns (controls). Blood obtained approximately 2 age up 3 urine samples were monthly...
Abstract Background and purpose Glymphatic dysfunction may play a significant role in the development of neurodegenerative diseases. We aimed to evaluate association between glymphatic risk malignant event/clinical milestones Parkinson disease (PD). Methods This study included 236 patients from August 2014 December 2020. Diffusion tensor imaging analysis along perivascular space (DTI‐ALPS) index was calculated as an approximate measure function. The primary outcomes were four clinical...
Parkinson's disease (PD), the second most common neurodegenerative disorder after Alzheimer's disease, is characterized by loss of nigral dopaminergic neurons. PD leads to a series clinical symptoms, including motor and non-motor disturbances. α-synuclein, major component Lewy bodies, hallmark lesion in PD. In this review, we concentrate on presenting latest research structure, distribution, function its interactions with We also summarize clinic applications which suggest use as biomarker,...
Perivascular spaces in the brain have been known to communicate with cerebrospinal fluid and contribute waste clearance animal models. In this study, we sought determine association between MRI-visible enlarged perivascular (EPVS) disease markers Parkinson's (PD). We obtained longitudinal data from 245 patients PD 98 healthy controls Progression Marker Initiative. Two trained neurologists performed visual ratings on T2-weighted images characterize EPVS centrum semiovale (CSO), basal ganglia...
Phenotype results from interactions between genetics and environment, but for most environmental chemical exposures, such are theoretical. The phenotypic response of the testis to in utero dibutyl phthalate (DBP) exposure was compared two strains Long-Evans (LE) rats, orl substrain with inherited cryptorchidism an outbred (wt) strain. wt LE rats were exposed daily gestational day (GD) 12 GD21 DBP dose levels ranging 50 200 mg/kg by oral gavage sensitive testicular end points examined at...
Rationale: A dural arteriovenous fistula (DAVF) refers to an abnormal direct connection between intracranial artery and a venous sinus. DAVF presenting with parkinsonism is rare, therefore easily misdiagnosed. Therefore, early consideration of in the differential diagnosis reversible necessary. Patient concerns: We present case 51-year-old male progressive parkinsonism. Diagnoses: He was diagnosed as straight sinus occlusion. Imaging studies revealed associated cerebral hypoperfusion...