A5027937670- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Machine Learning in Healthcare
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cancer-related molecular mechanisms research
- Vestibular and auditory disorders
- Genetics and Neurodevelopmental Disorders
- Glycogen Storage Diseases and Myoclonus
- Health, Environment, Cognitive Aging
- Hearing, Cochlea, Tinnitus, Genetics
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Syphilis Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- GDF15 and Related Biomarkers
- Ophthalmology and Eye Disorders
- Ear Surgery and Otitis Media
- Tattoo and Body Piercing Complications
- Bioinformatics and Genomic Networks
- Spinal Hematomas and Complications
- Circular RNAs in diseases
- Spinal Fractures and Fixation Techniques
- Autoimmune Neurological Disorders and Treatments
- Infectious Diseases and Tuberculosis
Zhejiang University
2021-2024
Zhejiang Hospital
2015-2024
Second Affiliated Hospital of Zhejiang University
2021
Zhejiang Center for Disease Control and Prevention
2018
Background Despite the importance of clinical heterogeneity in Parkinson’s disease (PD), its underlying pathophysiology remains unclear. Objective This study aimed to distinguish association free-water (FW) imaging data for cholinergic nuclei with motor subtypes PD. Methods The included 150 cases idiopathic PD from Progression Markers Initiative cohort. FW imaging, including FW-corrected diffusion tensor was used extract structural metrics nucleus 4 (Ch4) basal forebrain and pedunculopontine...
Abstract This study aimed to develop a machine learning (ML)-based tool for early and accurate prediction of in-hospital mortality risk in patients with spontaneous intracerebral hemorrhage (sICH) the intensive care unit (ICU). We did retrospective our identified cases sICH from MIMIC IV (n = 1486) Zhejiang Hospital databases 110). The model was constructed using features selected through LASSO regression. Among five well-known models, selection best based on area under curve (AUC)...
Abstract Aims Hyperbaric oxygen preconditioning (HBOP) attenuates brain edema, microglia activation, and inflammation after intracerebral hemorrhage (ICH). In this present study, we investigated the role of HBOP in ICH‐induced polarization potential involved signal pathway. Methods Male Sprague‐Dawley rats were divided into three groups: SHAM, ICH, ICH + group. Before surgery, SHAM groups received HBO for 5 days. Rats group needle injection, while 100 μL autologous blood injection right...
The present study aimed to examine how the long non‑coding RNA (lncRNA) RP11‑543N12.1 interacted with microRNA (miR)‑324‑3p modify microglials (MIs)‑induced neuroblastoma cell apoptosis, which may pose benefits treatment of Alzhemier's disease (AD). model AD was established by treating SH‑SY5Y cells amyloid β (Aβ)25‑35, and MI were acquired using primary culture technology. lncRNAs that differentially expressed between control screened through a microarray assay confirmed via polymerase...
Cerebral ischemic stroke (IS) is a complex disease caused by multiple factors including vascular risk factors, genetic and environment which accentuates the difficulty in discovering corresponding disease-related genes. Identifying genes associated with IS critical for understanding biological mechanism of IS, would be significantly beneficial to diagnosis clinical treatment cerebral IS. However, existing methods predict IS-related are mainly based on hypothesis guilt-by-association (GBA)....
Objective To assess the role of Machine Learning (ML) in identification critical factors dementia and mild cognitive impairment. Methods 371 elderly individuals were ultimately included ML analysis. Demographic information (including gender, age, parity, visual acuity, auditory function, mobility, medication history) 35 features from 10 assessment scales used for modeling. Five machine learning classifiers evaluation, employing a procedure involving feature extraction, selection, model...
Otosyphilis is a rare cause of audiovestibular dysfunction that can easily be misdiagnosed. Here, we report case in which patient presented with secondary benign paroxysmal positional vertigo (BPPV) 2 weeks after symptoms otosyphilis appeared. The Dix-Hallpike test showed classical response the head-hanging left position. was treated intravenous penicillin G and canalith repositioning maneuver, completely resolved vertigo. patient's gradually. elevated cerebrospinal fluid (CSF) white blood...
Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature
Objective To investigate the correlation between Framingham stroke risk profile(FSRP) and vascular cognitive impairment in stroke-free patients with cerebrovascular factors. Methods One hundred eighty-four subjects, selected from Zhejiang hospital, were divided into low group (56 subjects), moderate (70 subjects) high (58 according to their FSRP score, function including memory ability, attention, executive language ability assessed by Montreal assessment (MoCA), auditory verbal...
Backgrounds Early and accurate identification of patients with spontaneous intracerebral hemorrhage(sICH) who are at high risk in-hospital death can help intensive care unit (ICU) physicians make optimal clinical decisions. The aim this study was to develop a machine learning(ML)-based tool predict the in sICH ICU. Methods We conducted retrospective administrative database using MIMIC-IV Zhejiang Hospital database. outcome mortality. To validate final model, we employed LASSO regression...
Abstract Background Mechanical thrombectomy (MT) has been established as the first-line treatment for acute ischemic stroke (AIS) from large vessel occlusions. However, benefits of MT to patients over 80 years old is not yet clear, elderly with AIS were usually excluded randomized controlled clinical trials their poor prognosis. Methods This study enrolled 187 adult occlusions, including 53 ≥ old. Propensity score matching was used match patients༜80 those in a ratio 1:1. The divided into...
Objectives: This study was conducted to estimate diagnostic performance of dementia screening tests including Mini-Mental State Examination (MMSE), Mini-Cog, Clock Drawing Test (CDT) and Ascertain Dementia 8 questionnaire (AD8) without a gold standard by Bayesian method. Methods: 2015 participants aged 65 years or more in eastern China were enrolled. 4 administered scored specifically trained psychiatrists. The prior information sensitivity, specificity each are updated via Bayes’ theorem...
Objectives: This study was conducted to estimate the prevalence and associated risk factors of dementia mild cognitive impairment (MCI) in nursing homes (NHs) common communities (CCs) among elderly Zhejiang province China. Methods: We an investigation Southern China 2014. A total 2,015 subjects (1107 from CCs 908 NHs) aged 65 or older participated study. Trained nurses carried out relevant assessments, interviews collected information. Dementia (alzheimer's disease (AD), vascular (VaD)) MCI...
Objective This study was performed to investigate difference in the levels of serum regenerating islet-derived 1α protein (Reg-1α) expression patients with mild cognitive impairments (MCIs), ADs and health controls, explore Reg-1α level as a biomarker for early diagnosis AD. Methods A total 93 AD (AD group), 82 MCI (MCI 110 healthy controls (normal group) aged 60 90 years who were admitted from June 2015 2017 Zhejiang Hospital included. Peripheral blood samples subjects tested mRNA by...