A5115605042- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Medicinal Plant Pharmacodynamics Research
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Hepatitis C virus research
- Genetic and phenotypic traits in livestock
- TGF-β signaling in diseases
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Effects of Environmental Stressors on Livestock
- RNA Research and Splicing
- Gout, Hyperuricemia, Uric Acid
- Growth Hormone and Insulin-like Growth Factors
- Traditional Chinese Medicine Studies
Tibet University
2024
Zhejiang Hospital
2019
Lanzhou Army General Hospital
2016-2018
Huzhou Central Hospital
2017
Lanzhou University of Technology
2015
Chronic hepatitis C (CHC) is a contagious liver disease that results from infection with the virus (HCV). The most serious consequence of CHC HCV-related hepatocellular carcinoma (HCC).To illustrate clinical significance lncRNA HEIH expression in serum and exosomes development HCC.Thirty-five CHC, twenty-two HCV-induced cirrhosis ten HCC patients Huzhou Central Hospital January 2016 to September were recruited present study. Basic patient information, serological indicators, imaging data...
To investigate the effects of icariin on differentiation and maturation rat calvarial osteoblasts(ROB) in collagen hydrogel three-dimensional culture.ROB were obtained by enzyme digestion from segregated neonatal SD rats skull embedded 2 mg/mL tail for culture. The growth state ROB was observed FDA/PI staining, HE staining scanning electron microscopy. treated with at concentration 1 × 10⁻⁴, 10⁻⁵, 10⁻⁶ 10⁻⁷ mol/L respectively. activity alkaline phosphatase(ALP) detected after 3, 6, 9 d...
Objective: To investigate the effect of resveratrol on peak bone mineral density and mass in growing rats. Methods: Thirty-six female healthy Wistar rats were randomly divided into control group, icariin group with 12 each group. Icariin (25 mg·kg-1·d-1), (8.4 mg·kg-1·d-1) or equal volume distilled water given by gavage to respectively. The sacrificed after weeks. organ indexes calculated pathology sections observed; (BMD), biomechanics, serum metabolism index, results micro-CT scan...
Objective To study the effect of compound medicine tanshinone 2A and resveratrol on peak bone mass in growing rats to explore its possible mechanism,so as anti-osteoporosis mechanisms new traditional Chinese (TCM) drugs. Methods Totally 40 1-month-old female Wistar were randomly divided into group,resveratrol group,compound group (tanshinone resveratrol),and normal control group,with 10 each group. Body weight was measured once every two weeks,and whole body mineral density with dual-energy...
Objective: To investigate the effect of icariin total flavonoids capsules (ITFC) on bone mineral density (BMD) and histomorphometry in growing rats its anti-osteoporosis mechanism. Methods: Thirty female SD were randomly divided into 3 groups:normal control group, ITFC-1 group ITFC-2 group. Rats fed with 50 mg·kg-1·d-1 or 100 ITFC, respectively, those normal equal volume distilled water. The whole body BMD was measured after 4, 8 12 weeks, BMDs right femur lumbar vertebrae weeks. serum...
To compare the effect of icariin and genistein in osteogenic differentiation rat bone marrow stromal cells (rBMSC).Rat were seperated vitro, optimal concentration genisten icriin screened. Genistein with 1 x 10(-5) mol L(-1) adopted to intereven rBMSCs cultured vitro. Alkaline phosphatase (ALP) was determined at 3, 6, 9, 12,15 d after intervention; calcified nodule detected alizarin red staining 12 d; OXS, Runx-2, morphogenetic protein (BMP-2) Collagen-I mRNA expression observed Real-time...
To compare effects of resveratrol, puerarin and the compounds on peak bone mass in rats.Forty SPF Wistar rats weighed 109.45 g to 119.44 with an average 115.87 were selected. After 3 days' adaption, divided into control group (the same volume distilled water per day), group(15.4 mg/kg daily), resveratrol (8.4 compound drug (daily dose 8.4 added 15.4 puerarin) 10 each group. The body weight was monitored at every 7 days density measured month. All sacrificed after months. mineral femur...
To investigate the preventive effect and possible mechanism of puerarin(Pur) in rat model disuse osteoporosis(DOP),thirty healthy Wistar female rats 2 months old were randomly divided into control group(Control), hindlimb suspension group(HLS), puerarin group(HLS+Pur) suspension, with 10 each group. A osteoporosis was established by tail method, 15.4 mg·kg~(-1) administered to HLS+Pur group every day, same volume distilled water Control HLS respectively. After 28 days, sacrificed abdominal...