A5112367165- Nerve injury and regeneration
- Cancer Immunotherapy and Biomarkers
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Gut microbiota and health
- Tendon Structure and Treatment
- RNA modifications and cancer
- Neurogenesis and neuroplasticity mechanisms
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Gynecological conditions and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Reproductive System and Pregnancy
- Lung Cancer Treatments and Mutations
- Conducting polymers and applications
- Immune cells in cancer
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Hip disorders and treatments
- Uterine Myomas and Treatments
- Circular RNAs in diseases
Chinese PLA General Hospital
2016-2025
Huzhou Central Hospital
2016-2025
Huzhou University
2020-2025
Zhejiang Chinese Medical University
2024-2025
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
Hunan University
2023-2024
Nanjing Forestry University
2023-2024
Hunan Academy of Agricultural Sciences
2023-2024
First Affiliated Hospital of Harbin Medical University
2023-2024
Abstract Conductive gels are perfect for various sensor applications due to their inherent stretchability, flexibility, and electrical conductivity. However, poor environmental adaptability low fracture toughness restrict potential applications. In this study, resorcinol‐formaldehyde resin (RF) is used the first time as a rigid network compounded with flexible polyacrylic acid (PAA) successfully prepare double (DN) deep eutectic solvent gel (RF/PAA DN gel). The has high stress strength (1.04...
The realization of efficient optical interfaces for solid-state atom-like systems is an important problem in quantum science with potential applications communications and information processing. We describe demonstrate a technique coupling single nitrogen vacancy (NV) centers to suspended diamond photonic crystal cavities quality factors up 6000. Specifically, we present enhancement the NV center's zero-phonon line fluorescence by factor ~ 7 low-temperature measurements.
Chronic hepatitis C (CHC) is a contagious liver disease that results from infection with the virus (HCV). The most serious consequence of CHC HCV-related hepatocellular carcinoma (HCC).To illustrate clinical significance lncRNA HEIH expression in serum and exosomes development HCC.Thirty-five CHC, twenty-two HCV-induced cirrhosis ten HCC patients Huzhou Central Hospital January 2016 to September were recruited present study. Basic patient information, serological indicators, imaging data...
Graft-host mechanical mismatch has been a longstanding issue in clinical applications of synthetic scaffolds for soft tissue regeneration. Although numerous efforts have devoted to resolve this grand challenge, the regenerative performance existing remains limited by slow growth (comparing autograft) and failures. We demonstrate class rationally designed flexible network that can precisely replicate nonlinear responses tissues enhance regeneration via reduced graft-host mismatch. Such...
The incidence of acute Achilles tendon rupture appears to be increasing. aim this study was summarize various therapies for and discuss their relative merits.A PubMed search about the management performed. open original manuscripts review papers limited publication from January 2006 July 2017. A total 489 were identified initially finally 323 articles suitable review.The treatments include operative nonoperative treatments. Operative mainly consist repair, percutaneous mini-open augmentative...
<h3>Background</h3> Immune cells play a key role in cancer progression and treatment. It is unclear whether the clinicopathologic characteristics blood indexes of colorectal (CRC) patients could predict immune cell concentrations tumor microenvironment. <h3>Methods</h3> CRC with detailed data tissue who visited Sun Yat-sen University Cancer Center between April 1, 2004, September 2017, were enrolled. The densities CD3+ CD8+ T examined by immunohistochemistry both core (CT) invasive margin...
Tongue diagnosis, as a unique method of traditional Chinese medicine (TCM), was used to discriminate physiological functions and pathological conditions by observing the changes tongue coating. The aims present study were explore potential screening early diagnosis cancer through evaluating differences images coating microbiome on DS01-B diagnostic information acquisition system photograph analyze next-generation sequencing technology determine V2-V4 hypervariable regions 16S rDNA...
Electrical stimulation (ES) is widely applied to promote nerve regeneration. Currently, metal needles are used exert external ES, which may cause pain and risk of infection. In this work, a multiblock conductive scaffold with self-powered ES by the consumption glucose oxygen prepared. The substrate prepared in situ polymerization polypyrrole (PPy) on nanofibers bacterial cellulose (BC). Platinum nanoparticles electrodeposited anode side for oxidation, while nitrogen-doped carbon nanotubes...
Cell transplantation is an effective strategy to improve the repair effect of nerve guide conduits (NGCs). However, problems such as low loading efficiency and cell anoikis undermine outcomes. Microcarriers are efficient 3D culture scaffolds, which can also prevent by providing substrate for adhesion during transplantation. Here, we demonstrate first time microcarrier-based in peripheral repair. We prepared macroporous chitosan microcarriers (CSMCs) emulsion-phase separation method, then...
Abstract Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator which limits activity these transcriptional cofactors during developmental tumor angiogenesis by promoting their degradation. We show loss results in increased cell proliferation vitro various models vivo. This effect due to perturbed...
Abstract Photobiomodulation (PBM) has demonstrated potential in promoting peripheral nerve regeneration. However, there is a limited and inconclusive study on the application of light‐emitting diode (LED) for injury repair. In this study, we designed an 807‐nm LED device with high luminous uniformity to investigate effects LED‐based PBM RSC96 cells were utilized as target optimal light parameters selected based ATP concentration, CCK‐8 assays, PCR, immunofluorescent staining. One‐way...
Multiple primary malignancies (MPM) are two or more independent malignancies. Recently, the relationship between microbiome and various tumors has been gradually focused on. To describe MPM patients (MPMs) gut microbiome. A total of 27 MPMs, 30 colorectal cancer (CRCs), healthy individuals were included to obtain metagenomic sequencing data. The knowledge graphs bacteria enteroviruses plotted based on metagenomics. Wilcoxon rank-sum test was used screen characteristic graph in plotted. 26...
Nerve conduits enhance nerve regeneration in the repair of long-distance peripheral defects. To help optimize effectiveness for repair, we developed a multi-step electrospinning process constructing guide with aligned nanofibers. The alignment was characterized by scanning electron microscopy and fast Fourier transform. mechanical performance assessed testing tensile strength compression resistance. biological fibers examined using Schwann cells, PC12 cells dorsal root ganglia vitro....
Tendon, a connective tissue structure, serves the crucial role of transmitting force between muscles and bones. However, tendon injury repair continues to pose significant challenge in clinical settings. In this study, we utilized single-cell RNA sequencing delve into cell populations signaling pathways that are integral healing. Our findings suggest hypoxia plays pivotal activating macrophages, stimulating endothelial migration, fostering fibroblast proliferation. Based on these insights,...
Background: Abnormal lipid metabolism is considered to be one of main promoters colorectal cancer (CRC), and intestinal microorganisms may involved in CRC patients with abnormal metabolism.Objective: To investigate explore the role complicated metabolism.Methods: Overall, 150 Huzhou Central Hospital from January 2016 September 2017 were recruited present study. Basic patient information clinical serological indicators investigated analyzed. Twenty-one stool samples collected after receiving...
Abstract Background The colorectum includes ascending colon, transverse descending sigmoid and rectum. Different sites of colorectal cancer (CRC) are different in many aspects, including clinical symptoms, biological behaviour, prognosis. Purpose This study aimed to analyse prognosis, genes, bacteria, fungi, microbial metabolome CRC. Methods Surveillance, Epidemiology, End Results (SEER) database STAT were used statistically describe the prognosis RNA sequences CRC from Broad Institute’s...
Directional axon regeneration and remyelination are crucial for repair of spinal cord injury (SCI), but existing treatments do not effectively promote those processes. Here, we propose a strategy construction niche-specific white matter-like tissue (WMLT) using decellularized optic nerve (DON) loaded with neurotrophin-3 (NT-3)-overexpressing oligodendrocyte precursor cells. A rat model matter defect in the dorsal T10 segment was used. The WMLT transplantation group showed significant...