A5100671615- Dementia and Cognitive Impairment Research
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Amino Acid Enzymes and Metabolism
- Drug Transport and Resistance Mechanisms
- Retinoids in leukemia and cellular processes
- Diabetes Management and Education
- Traditional Chinese Medicine Studies
- Sodium Intake and Health
- Cardiovascular Health and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Health disparities and outcomes
- Systemic Lupus Erythematosus Research
- Carbohydrate Chemistry and Synthesis
- Healthcare Systems and Reforms
- Global Health Care Issues
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Blood Pressure and Hypertension Studies
- Alzheimer's disease research and treatments
- T-cell and B-cell Immunology
- Biomedical Research and Pathophysiology
Zhejiang Hospital
2021-2023
Minzu University of China
2023
ORCID
2021
Central University of Finance and Economics
2020
Qingdao University
2019
Zhejiang Center for Disease Control and Prevention
2018
Changsha Central Hospital
2016
Ruijin Hospital
2016
Tianjin Medical University General Hospital
2013
China Medical University
2012
Numerous α-galactosidase A (α-gal A) gene (GLA) mutations have been identified in Fabry disease (FD), but studies on genotype-phenotype correlation are limited. This study evaluated the features of GLA and relationship Chinese FD patients. Gene sequencing results, demographic information, clinical history, laboratory findings were collected from 73 Totally 47 identified, including 23 novel which might be pathogenic. For male patients, those with frameshift nonsense presented classical FD,...
The relationship between maternal vitamin A deficiency during pregnancy and infant mortality is unclear. We conducted a prospective cohort study of 377 HIV-negative women their infants in Blantyre, Malawi. Serum levels were measured the second or third trimester followed first year life. From delivery until 12 months age, 18 died (47.7 per 1000). Mothers who had lower serum (0.74 ± 0.13 μmol/l) compared with mothers did not die (1.02 0.03μmol/l) (p = 0.055). Infants born to whose lowest...
We investigated a possible association of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) Gly482Ser polymorphism with hypertension in Mongolians Inner Mongolia.A total 787 subjects were enrolled randomly, including 390 patients and 397 healthy controls.Triglycerides, cholesterol, fasting plasma glucose measured, body mass index was calculated.PCR-RFLP used to analyze polymorphisms.There significant differences triglycerides, glucose, between controls.Cholesterol...
Health issues have become one of the most important for elderly in their later years. Especially with aging our country, "Healthy China" has a hot issue government and academia. Based on CLHLS 2014 survey data, this paper uses structural equation model analysis. The study found that both old-age security medical significantly improve subjective health indicators own evaluation health, by others, change, life satisfaction. reducing two-week discomfort two years severe illness objective...
To explore the association between tag single nucleotide polymorphism (tag SNP) of adenylyl cyclase 3 (ADCY3) and essential hypertension (EH).From April to July 2013, a total 1 061 subjects diagnosed with EH 218 control were recruited from Ningbo, Zhejiang Province. Information was collected by face-to-face interview. Twelve SNPs detected ligase detection reaction technique.After adjusted for age, gender, body mass index other related factors, logistic regression analysis showed that loci...
Studies have suggested that interleukin-10 receptor1 (IL-10R1) is involved in genetic susceptibility to systemic lupus erythematosus (SLE) animal models and Caucasians. Therefore, the current study was designed determine whether IL-10R1 gene plays a role pathogenesis of human SLE Chinese Han population.The seven exons were amplified sequenced using BigDye Terminator v1.1 Cycle Sequencing kit an ABI 3100 DNA Analyzer. A missense single nucleotide polymorphism (SNP) locus with minor allele...
Aims: This work was designed to provide early diagnosis strategies for Alzheimer's disease (AD) based on the identification of blood metabolic biomarkers. Patients & methods: A total 90 subjects aged 60 years or older were included in this study; 45 patients assigned case group and control group, respectively. 31 target metabolites quantitatively analyzed by parallel reaction monitoring between two groups. Results conclusion: Three screened out, including cystine, serine alanine/sarcosine....
Objective Forkhead box a2 (Foxa2) is proven to be an insulin-sensitive transcriptional regulator and affects hepatic steatosis. This study aims investigate the mechanism by which Foxa2 nonalcoholic fatty liver disease (NAFLD). Methods Animal cellular models of NAFLD were constructed using high-fat diet (HFD) feeding oleic acid (OA) stimulation, respectively. mice received tail vein injections either overexpressing negative control (oe-NC) or (oe-Foxa2) for four weeks. HepG2 cells transfected...
Objectives: This study was conducted to estimate the prevalence and associated risk factors of dementia mild cognitive impairment (MCI) in nursing homes (NHs) common communities (CCs) among elderly Zhejiang province China. Methods: We an investigation Southern China 2014. A total 2,015 subjects (1107 from CCs 908 NHs) aged 65 or older participated study. Trained nurses carried out relevant assessments, interviews collected information. Dementia (alzheimer's disease (AD), vascular (VaD)) MCI...
Abstract Background: It has been proposed that some risk factors of cardiovascular disease (CVD) are associated with and contribute to the development all cause dementia. Our aim was examine short trends cognitive impairment among a eastern Chinese population at high CVD. Methods: We used convenience sampling strategy select 7 subdistricts in Zhejiang province, which part China Patient-Centered Evaluative Assessment Cardiac Events (PEACE) project. Participants 2018 (n=3089) 2020 (n=3082) CVD...