A5102305250- Renal Diseases and Glomerulopathies
- Lysosomal Storage Disorders Research
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Carbohydrate Chemistry and Synthesis
- Platelet Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Celiac Disease Research and Management
- Blood groups and transfusion
- Urinary Bladder and Prostate Research
- Biomedical Research and Pathophysiology
- Eosinophilic Esophagitis
- Folate and B Vitamins Research
- Diabetes and associated disorders
- Pharmacogenetics and Drug Metabolism
- Dialysis and Renal Disease Management
- Drug-Induced Hepatotoxicity and Protection
- Chronic Lymphocytic Leukemia Research
- Biological Research and Disease Studies
- Cellular transport and secretion
- Renal and Vascular Pathologies
- Sphingolipid Metabolism and Signaling
- Complement system in diseases
- Diabetes Treatment and Management
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2016-2024
Huazhong University of Science and Technology
2024
General Hospital of Guangzhou Military Command
2012-2018
Vanderbilt University
1997
Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from 2005-2008 National Health Nutrition Examination Survey Wei Du,1,* Jun Liu,2,* Jianlong Zhou,1,* Dan Ye,3 Yan OuYang,4 Qingnan Deng11Respiratory Diseases Group, 6th Unit, Department of Internal Medicine, Guangzhou General Hospital Military Command, 510010, China; 2Department Gerontology, 3Luopu Street Community Service Centre, 511431, 4Department Respiratory China *These authors contributed equally to this...
A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated independent cohorts before it can widely applied to clinical practice. Biopsy-proven IgAN patients were continuously recruited from two large centers China 1989 2014. All followed for more than 1 year unless end stage disease (ESRD) occurred within 12 months. Crescents defined as focal...
Studies on the relationship between body mass index (BMI) and renal progression in IgA Nephropathy (IgAN) were limited, especially for underweight patients with IgAN. To elucidate clinical features effect of function deterioration this disease, we recruited IgAN diagnostic age ≥18 years old a baseline estimated glomerular filtration rate (eGFR) ≥15 ml/min/1.73m2 from our center 1985 2014. Patients secondary to systemic diseases or follow-up less than 6 months excluded. All patients' data at...
Background and objectives At least 20 susceptibility loci of IgA nephropathy have been identified by genome-wide association studies to date. Whether these were associated with disease progression is unclear. Design, setting, participants, & measurements We enrolled 613 adult patients for a follow-up ≥12 months. All selected their tag single nucleotide polymorphisms (SNPs) genotyped. After strict quality control, 16 SNPs 517 eligible subsequent analysis. Progression was defined as ESKD...
Numerous α-galactosidase A (α-gal A) gene (GLA) mutations have been identified in Fabry disease (FD), but studies on genotype-phenotype correlation are limited. This study evaluated the features of GLA and relationship Chinese FD patients. Gene sequencing results, demographic information, clinical history, laboratory findings were collected from 73 Totally 47 identified, including 23 novel which might be pathogenic. For male patients, those with frameshift nonsense presented classical FD,...
Although plasma globotriaosylsphingosine (lyso‑Gb3) is a promising biomarker of Fabry disease (FD), few studies have assessed the impact lyso‑Gb3 in patients with FD. A total 38 diagnosed FD at Ruijin Hospital between January 2012 and December 2014 were recruited current study. An additional 120 unrelated healthy individuals selected as controls. simplified liquid chromatography‑tandem mass spectrometry (LC‑MS/MS) assay was performed to determine levels plasma. Protein precipitation...
The aim of this study was to investigate the association between lectin pathway-related genetic variations and progression in IgA nephropathy. Biopsy-proven IgAN patients with eGFR ≥15 ml/min/1.73 m2 at baseline a minimum follow-up 12-months were enrolled. A total 1,007 121 healthy controls enrolled from two Chinese renal centers. discovery cohort consisted 606 patients, validation 401 patients. First, promoters, all exons their boundary regions MBL2 FCN2 sequenced 50 then 37 identified. Of...
Kidney damage is common in patients with Fabry disease (FD), but more accurate information about the risk of progression to kidney failure needed for clinical decision-making. In particular, FD mild renal involvement often lack timely intervention and treatment. We aimed utilize a model predict patients. Between November 2011 2019, ERT-naive were recruited from three medical centers China. To assess 50% decline estimated glomerular filtration rate (eGFR) or end-stage (ESKD), Cox proportional...
// Meng Yang 1 , Jingyuan Xie Yan Ouyang Xiaoyan Zhang Manman Shi Xiao Li Zhaohui Wang Pingyan Shen Hong Ren Wen Weiming and Nan Chen Department of Nephrology, Institute Ruijin Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China Correspondence to: Chen, email: Xie, Keywords : IgA nephropathy, ABO blood group, renal progression, end-stage disease, clinical follow-up, Immunology Microbiology Section, Immune response, Immunity Received July 18, 2017 Accepted August 06,...
IntroductionFamilial IgA nephropathy (IgAN) has been widely reported. However, its clinicohistologic characteristics and long-term prognosis are not clear.MethodsA total of 348 familial IgAN cases from 167 independent families were recruited their as well lifetime risk end-stage renal disease (ESRD) compared to 1116 sporadic patients the same geographic region.ResultsOf all patients, 60 (17%) came 32 single-generation (SG; affected individuals siblings) families, whereas 286 (82%) 134...
ABSTRACT Background Few studies have evaluated the treatment of immunoglobulin A nephropathy (IgAN) patients with nephrotic syndrome (NS) and mesangioproliferative glomerulonephritis (MPGN). The aim this study was to compare therapeutic effects oral glucocorticoids (GCS) combined intravenous cyclophosphamide (CTX) GCS alone in MPGN-IgAN NS. Methods Biopsy-proven primary IgAN who were aged ≥14 years at diagnosis, had coexistent NS MPGN estimated glomerular filtration rate (eGFR) ≥15...
Abstract Background and Aims Fabry disease (FD) is a rare inherited lysosomal storage caused by pathogenic GLA gene variants which result in deficiency of the enzymatic activity α-galactosidase A. Enzyme replacement therapy (ERT) mainstay FD-specific treatment, but there are currently no reported clinical trials ERT for FD Chinese population. This first phase 4 study to evaluate safety efficacy China since approval agalsidase beta 2019. Method A 54-week, 4, open label, single arm,...
This study investigates the link between genetic variants associated with kidney function and immunoglobulin A (IgA) nephropathy (IgAN) progression.
Fu, Xiaocen; Ren, Hong; Xie, Jingyuan; Ouyang, Yan; Li, Xiao; Chen, Nan Author Information
INTRODUCTION AND AIMS: Conflicting data exists on the role of complement lectin pathway and its recognition molecules in disease progression IgA nephropathy (IgAN), underlying mechanism is not elucidated.The aim this study to investigate associations underline variations mannose binding (MBL), L-ficolin IgAN based an extend cohort Chinese patients.METHODS: we enrolled 613 patients carried out a two stage genetic study.Renal outcomes were defined as End-stage renal (ESRD; dialysis or...