A5100358060- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Atherosclerosis and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Chronic Kidney Disease and Diabetes
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Acute Ischemic Stroke Management
- Cytokine Signaling Pathways and Interactions
- Virus-based gene therapy research
- IL-33, ST2, and ILC Pathways
- Signaling Pathways in Disease
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Dementia and Cognitive Impairment Research
- Iron Metabolism and Disorders
- Ear and Head Tumors
- Musculoskeletal synovial abnormalities and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Renal Diseases and Glomerulopathies
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Retinal Imaging and Analysis
- Cardiac Structural Anomalies and Repair
GlaxoSmithKline (United States)
2023-2024
Union Hospital
2011-2024
Huazhong University of Science and Technology
2015-2024
Sichuan Cancer Hospital
2015-2024
Wuhan Union Hospital
2012-2023
Southern Medical University
2023
Cleveland Clinic
2023
Analysis Group (United States)
2023
Boston University
2023
Pratt Institute
2022
Sarcopenia is the age-related loss of skeletal muscle mass and strength or physical function. It most common in elderly individuals. Due to its high incidence, insidious onset, extensive impact on body, it has a huge family medical burden social public health expenditure China. The understanding sarcopenia China still lacking, recommendations for prevention, control, intervention are not clear unified. purpose this consensus report standardize methods patients China; improve efficacy...
A key hallmark of myelofibrosis is anemia, which ranges from mild to severe based on hemoglobin levels. To more clearly define outcomes with the Janus kinase (JAK) 1/JAK2/activin receptor type 1 inhibitor momelotinib by anemia severity, we performed a descriptive post hoc exploratory analysis double-blind, randomized, phase 3 SIMPLIFY-1 study (NCT01969838;
Chronic kidney disease (CKD) represents a significant global public health issue, with its incidence and prevalence escalating annually. Metabolic disorders are one of the major etiological factors CKD. This study investigates relationship between emerging metabolic index triglyceride-glucose body mass (TyG-BMI) onset Our enrolled 3,485 healthy participants (1,576 men 1,909 women), follow-up period 3 years. The primary outcome was emergence CKD, defined by an eGFR less than 60 mL/(min × 1.73...
Hypertension is a highly prevalent disease and the leading cause of chronic kidney (CKD). Metabolic syndrome could also be risk factor for CKD. We sought to study association between metabolic components prevalence CKD in patients with hypertension.We carried out multi-center cross-sectional from Apr. 2017- 2018 15 cities China.A total 2484 hypertension were enrolled. Among them, 56% male average age was 65.12 ± 12.71 years. The systolic BP/diastolic BP 142 18/83 12 mmHg. turned...
<b><i>Aim:</i></b> The aim of this study is to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features in patients with papillary thyroid carcinoma (PTC). <b><i>Methods:</i></b> We performed an analysis 843 patients, including 321 PTC, 83 adenoma 439 nodular goiter (NG). Thyroglobulin thyrotropin were measured each patient. Neutrophils, lymphocytes, platelets counted. Statistical was used correlate...
Cardiac fibrosis triggered by pressure overload represents one of the major challenges in treatment cardiovascular diseases. MicroRNA (miRNA/miR)‑155, a member small RNA family, has previously been demonstrated to be associated with cardiac inflammation. However, effect miR‑155 on induced angiotensin II (Ang II), particularly fibroblasts, requires further investigation. The present study aimed investigate Ang II‑induced using animal models and fibroblasts. Animal were established male...
Abstract Studies examining the associations between interleukin‐6 ( IL‐6 ) rs1800795 and rs1800796 gene polymorphisms risk of coronary artery disease (CAD) remain controversial. Our aim was to evaluate accurately determine role these two in CAD risk. PubMed, Embase, VIP, Wan fang China National Knowledge Infrastructure databases were searched. The odds ratios (ORs) 95% confidence intervals (CIs) calculated. trial sequential analysis (TSA) conducted, bioinformatics tools employed. A total...
Background Atrial fibrillation (AF) is a serious complication of dilated cardiomyopathy (DCM), which increases the risk thromboembolic events and sudden death in DCM patients. However, common mechanism combined with AF remains unclear. This study aims to explore molecular analyze immune infiltration complicated through comprehensive bioinformatics analysis. Methods The gene expression datasets (GSE141910) (GSE41177 GSE79768) were obtained from Gene Expression Omnibus database. enrichment...
Pralsetinib has demonstrated efficacious activity in various solid tumors, including medullary thyroid cancer (MTC), as observed the phase 1/2 global ARROW study (BLU-667-1101; NCT03037385). We evaluated safety and efficacy of pralsetinib Chinese patients with advanced RET -mutant MTC. In extension cohort ARROW, adult MTC, who had not received systemic therapy (except for cytotoxic chemotherapy), were treated (400 mg once daily, orally). The primary endpoints blinded independent...
6574 Background: Pts with MF experience debilitating symptoms that negatively impact health-related quality of life (HRQOL), a burden compounded in those anemia. Prior analysis the phase 3 SIMPLIFY-1 (S1) and SIMPLIFY-2 (S2) trials found achieving transfusion independence at wk 24 was associated improved PROs, but association anemia severity by Hb level PROs inconclusive (Mesa, ASCO 2023, Poster 7066). This new post hoc explored improvement on pts Methods: The pooled treatment-agnostic set...
No-reflow phenomenon due to cardiac microvascular dysfunction or disturbance aggravates clinic outcomes of a portion patients with acute myocardial infarction undergoing percutaneous coronary intervention thrombolytic therapy. Our working hypothesis was that microthrombosis would play an important role in the pathogenesis. We investigated microthrombi were observed by Martius, Scarlet, Blue methocl (MSB) and Masson trichrome staining. Furthermore, we expression fibrinogen-like protein 2...
Cholesterol-metabolism-associated molecules, including scavenger receptor class A (SR-A), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), CD36, ACAT1, ABCA1, ABCG1, and B type I, can modulate cholesterol metabolism in the transformation from macrophages to foam cells. Voltage-gated potassium channel Kv1.3 has increasingly been demonstrated play an important role modulation of macrophage function. Here, we investigate modulating cholesterol-metabolism-associated molecules...
7066 Background: MF is associated with substantial symptom burden that can negatively impact pt quality of life (QOL). Transfusions may reduce anemia-associated symptoms, but be burdensome and carry complications affect social, emotional, general health; thus, QOL further affected in transfusion-dependent (TD) pts. To characterize the relationship between transfusion pt-reported outcomes (PROs), we report an exploratory post hoc analysis phase 3 S1 S2 trials JAK1/JAK2/ACVR1 inhibitor...
Ewing sarcoma is a highly resistant disease with <10% chance of survival at 5 years after failure frontline chemotherapy. This case report an patient metastatic recurrence <2 standard chemotherapy/radiation who achieved durable and sustained complete response 2 series treatments Vigil (GMCSF/bi-shRNA furin DNA autologous tumor immunotherapy) serially manufactured from first second recurrences ELISPOT assay correlation. Results support justification further testing as biomarker to assess...
Abstract Background the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score is a recognised tool for stratification. However, its application limited due to requirements multidimensional information fasting blood draw. Consequently, an effective non-invasive screening individuals with high in large population-based settings urgently needed. Methods deep learning algorithm based on fundus photographs estimating CAIDE was developed internally validated by...