A5062248785- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Digestive system and related health
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Genetic factors in colorectal cancer
- 3D Printing in Biomedical Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Renal and related cancers
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Genomics and Chromatin Dynamics
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Kruppel-like factors research
- Helicobacter pylori-related gastroenterology studies
- Neonatal Respiratory Health Research
- Cancer-related Molecular Pathways
University Medical Center Utrecht
2016-2025
Oncode Institute
2017-2025
Princess Máxima Center
2016-2025
Roche (Switzerland)
2022-2025
Royal Netherlands Academy of Arts and Sciences
2016-2025
Hubrecht Institute for Developmental Biology and Stem Cell Research
2016-2025
The Netherlands Cancer Institute
1989-2024
Givaudan (Netherlands)
2024
Philips (United States)
2023
Utrecht University
2010-2021
Inactivation of the adenomatous polyposis coli ( APC ) tumor suppressor gene initiates colorectal neoplasia. One biochemical activities associated with protein is down-regulation transcriptional activation mediated by β-catenin and T cell transcription factor 4 (Tcf-4). The products mutant genes present in tumors were found to be defective this activity. Furthermore, intact contain activating mutations that altered functionally significant phosphorylation sites. These results indicate...
The adenomatous polyposis coli (APC) tumor suppressor protein binds to beta-catenin, a recently shown interact with Tcf and Lef transcription factors. gene encoding hTcf-4, family member that is expressed in colonic epithelium, was cloned characterized. hTcf-4 transactivates only when associated beta-catenin. Nuclei of APC-/- colon carcinoma cells were found contain stable beta-catenin-hTcf-4 complex constitutively active, as measured by reporter gene. Reintroduction APC removed beta-catenin...
Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of with distinct phenotypes PDA exist. We identified a CAF subpopulation elevated expression α-smooth muscle actin (αSMA) located immediately adjacent to neoplastic mouse human...
Intestinal organoids as an infection model Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes influenza-like disease with a transmission route; however, patients often present gastrointestinal symptoms such diarrhea, vomiting, and abdominal pain. Moreover, the virus has been detected in anal swabs, cells inner-gut lining express receptor that SARS-CoV-2 uses to gain entry cells. Lamers et al. used human intestinal organoids, “mini-gut” cultured dish, demonstrate readily...
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that time is ripe to complete 150-year-old effort identify all cell types human body. Human Cell Atlas Project an international collaborative aims define terms distinctive profiles (such as gene expression profiles) and connect this information with classical cellular descriptions location morphology). An open comprehensive reference map state cells...