Matthias Edinger
A5081701091- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Gut microbiota and health
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Mycobacterium research and diagnosis
- bioluminescence and chemiluminescence research
- Medical Imaging Techniques and Applications
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Hemoglobinopathies and Related Disorders
- Childhood Cancer Survivors' Quality of Life
- Mesenchymal stem cell research
- Neutropenia and Cancer Infections
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
University Hospital Regensburg
2016-2025
University of Regensburg
2012-2024
Leibniz Association
2022-2024
Leibniz Institute for Immunotherapy
2022-2024
Krankenhaus Barmherzige Brüder
2024
Bayer (Germany)
2024
University Medical Center
2012-2023
German Cancer Research Center
2023
Praxis für Humangenetik
2007
Stanford University
1999-2005
Acute graft-versus-host disease (aGVHD) is still a major obstacle in clinical allogeneic bone marrow (BM) transplantation. CD4+CD25+ regulatory T (Treg) cells have recently been shown to suppress proliferative responses of CD4+CD25− alloantigenic stimulation vitro and are required for ex vivo tolerization donor cells, which results their reduced potential induce aGVHD. Here we show that isolated from the spleen or BM C57BL/6 (H-2b) mice not tolerized potent inhibitors alloresponse lethal...
These guidelines are a consensus work of considerable number members the immunology and flow cytometry community. They provide theory key practical aspects enabling immunologists to avoid common errors that often undermine immunological data. Notably, there comprehensive sections all major immune cell types with helpful Tables detailing phenotypes in murine human cells. The latest techniques applications also described, featuring examples data can be generated and, importantly, how analysed....
Abstract The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg). Their number functioning appears to be crucial in the prevention autoimmunity allergy, but also a negative prognostic marker various solid tumors. Although expression currently constitutes best‐known Treg, humans, transient observed activated non‐Treg. Extending our recent findings murine foxp3 locus, we epigenetic modification several regions human locus exclusively occurring Treg....
Next-generation sequencing of the hypervariable V3 region 16s rRNA gene isolated from serial stool specimens collected 31 patients receiving allogeneic stem cell transplantation (SCT) was performed to elucidate variations in composition intestinal microbiome course SCT. Metagenomic analysis complemented by strain-specific enterococcal PCR and indirect assessment bacterial load liquid chromatography-tandem mass spectrometry urinary indoxyl sulfate. At time admission, showed a predominance...
Abstract The adoptive transfer of CD4 + CD25 natural regulatory T cells (Treg) is a promising strategy for the treatment autoimmune diseases and prevention alloresponses after transplantation. Clinical trials exploring this require efficient in vitro expansion rare cell population. Protocols developed thus far rely on high‐grade purification Treg prior to culture initiation, process still hampered by lack cell‐specific surface markers. Depletion CD127 was shown separate activated...
Chronic myeloid leukemia (CML)-study IV was designed to explore whether treatment with imatinib (IM) at 400 mg/day (n=400) could be optimized by doubling the dose (n=420), adding interferon (IFN) (n=430) or cytarabine (n=158) using IM after IFN-failure (n=128). From July 2002 March 2012, 1551 newly diagnosed patients in chronic phase were randomized into a 5-arm study. The study powered detect survival difference of 5% 5 years. After median observation time 9.5 years, 10-year overall 82%,...
Abstract In the FANTOM5 project, transcription initiation events across human and mouse genomes were mapped at a single base-pair resolution their frequencies monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands samples, consisting variety primary cells, tissues, cell lines, time series samples during activation development, subjected to uniform pipeline data production. The analysis started measuring RNA extracts assess...
Specialized regulatory T (Treg) cells accumulate and perform homeostatic regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg exist how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of 33 (IL-33) receptor ST2-expressing tissue cells, which resided the spleen lymph nodes. Global chromatin...
Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg with these functions healthy tissues. Single-cell chromatin accessibility profiles of murine defined a conserved, microbiota-independent tissue-repair signature prevailing footprint the transcription factor BATF. This signature, combined gene expression profiling TCR fate mapping, identified population tissue-like peripheral blood expressed...
Abstract Belumosudil is a first in class ROCK2-inhibitor approved by the FDA for 3rd line treatment of chronic graft-versus-host disease (cGvHD). In this retrospective real-world analysis, we report safety and efficacy data belumosudil from 5 German/Swiss transplant centers. A total 33 adult patients (median age 59 years) with moderate ( n = 2) or severe 31) cGvHD were treated on individual request due to lack EMA approval. The patient cohort had long history 44 months) was heavily...
Revealing the mechanisms of neoplastic disease and enhancing our ability to intervene in these processes requires an increased understanding cellular molecular changes as they occur intact living animal models. We have begun address needs by developing a method labeling tumor cells through constitutive expression optical reporter gene, noninvasively monitoring proliferation vivo using sensitive photon detection system. A stable line HeLa that expressed modified firefly luciferase gene was...
DNA methylation participates in establishing and maintaining chromatin structures regulates gene transcription during mammalian development cellular differentiation. With few exceptions, research thus far has focused on promoters, little is known about the extent, functional relevance, regulation of cell type-specific at promoter-distal sites. Here, we present a comprehensive analysis differential human conventional CD4 + T cells (Tconv) CD25 regulatory (Treg), types whose differentiation...
We have previously reported on the ex vivo generation of cytotoxic effector cells, termed cytokine-induced killer (CIK) that both in vitro and antitumor activity murine models. now report our efforts for large-scale expansion CIK cells also present preliminary results from a phase I clinical trial. Nine patients with advanced Hodgkin disease (n = 7) non-Hodgkin lymphoma 2), all whom had relapsed after an autologous transplantation, were treated escalating doses (3 at each dose level 1 × 109,...