A5019255933- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Blood properties and coagulation
- Signaling Pathways in Disease
- Gout, Hyperuricemia, Uric Acid
- Pancreatic function and diabetes
- Cardiac Valve Diseases and Treatments
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Alcohol Consumption and Health Effects
- Genomics and Chromatin Dynamics
- Estrogen and related hormone effects
- Diabetes Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Colorectal Cancer Treatments and Studies
- Diabetes and associated disorders
- Aldose Reductase and Taurine
- Birth, Development, and Health
Osaka University
2015-2024
Kindai University
2023
University of Occupational and Environmental Health Japan
2020
Tokyo Metropolitan Neurological Hospital
2017-2020
RIKEN Center for Integrative Medical Sciences
2001-2015
Iwate Medical University
2014
Osaka Ekisaikai Hospital
2013
Yamaguchi University
2005-2010
Duke University
2009
Duke University Hospital
2009
Abstract The FANTOM5 project investigates transcription initiation activities in more than 1,000 human and mouse primary cells, cell lines tissues using CAGE. Based on manual curation of sample information development an ontology for classification, we assemble the resulting data into a centralized resource ( http://fantom.gsc.riken.jp/5/ ). This contains web-based tools data-access points research community to search extract related samples, genes, promoter activities, factors enhancers...
Adiponectin, an adipocyte-derived circulating protein, accumulates in vasculature, heart, and skeletal muscles through interaction with a unique glycosylphosphatidylinositol-anchored cadherin, T-cadherin. Recent studies have demonstrated that such accumulation is essential for adiponectin-mediated cardiovascular protection. Here, we demonstrate the adiponectin/T-cadherin system enhances exosome biogenesis secretion, leading to decrease of cellular ceramides. Adiponectin accumulated inside...
Adiponectin, an adipocyte-derived protein abundant in the circulation, is thought to be protective against atherosclerosis. However, it not fully understood how association of adiponectin with vascular cells and its antiatherogenic effect are connected. In this study, T-cadherin was essential for accumulation neointima atherosclerotic plaque lesions, adiponectin–T-cadherin protected injury. apolipoprotein E-knockout (ApoE-KO) mice, colocalized on en-dothelial synthetic smooth muscle aortic...
Skeletal muscle has remarkable regenerative potential and its decline with aging is suggested to be one of the important causes loss mass quality life in elderly adults. Metabolic abnormalities such as obesity were linked regeneration. On other hand, plasma levels adiponectin are decreased metabolic conditions. However, have been shown inversely correlate strength people especially chronic heart failure (CHF). Here we addressed whether some impact on regeneration after cardiotoxin-induced...
COVID-19 can cause multiple organ damages as well metabolic abnormalities such hyperglycemia, insulin resistance, and new onset of diabetes. The insulin/IGF signaling pathway plays an important role in regulating energy metabolism cell survival, but little is known about the impact SARS-CoV-2 infection. aim this work was to investigate whether infection impairs host cell/tissue, if so, potential mechanism association with pathology.To determine on pathway, we utilized transcriptome datasets...
Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) or death-ligand (PD-L1) have improved the treatment of a broad spectrum cancers. These immune checkpoint inhibitors (ICIs) reactivate system against tumour cells but can also trigger autoimmune side effects, including type diabetes. Mesenchymal stem (MSC) therapy is most prevalent therapy, with tissue-regenerating, anti-fibrosis immunomodulatory functions provided by secretome...
Excess of visceral fat is a central factor in the pathogenesis metabolic syndrome (MetS) and atherosclerosis. However, little known about how much epicardial affects cardiometabolic disorders comparison with or subcutaneous fat.Methods Results:Participants suspected as having angina pectoris underwent cardiac computed tomography (CT) imaging. Of them, 374 subjects were analyzed association clinical characteristics CT-based distribution measured volume (EFV), area (VFA), (SFA). EFV was highly...
Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia in the elderly have been increasing worldwide, associations among visceral fat accumulation, skeletal muscle indices (mass, strength, quality) cardiovascular diseases T2DM remain poorly investigated.We enrolled 183 Japanese inpatients (126 men, 57 women; mean age 64.7 ± 12.6 years, SD). The estimated-visceral area (eVFA) mass were measured by each device using bioelectrical impedance analysis method. We also grip...
Adiponectin, an adipocyte-derived circulating protein, accumulates in the heart, vascular endothelium, and skeletal muscles through interaction with T-cadherin (T-cad), a unique glycosylphosphatidylinositol-anchored cadherin. Recent studies have suggested that this is essential for adiponectin-mediated cardiovascular protection. However, precise protein-protein between adiponectin T-cad remains poorly characterized. Using ELISA-based surface plasmon analyses, we report here fused IgG Fc as...
Adiponectin is an adipocyte-derived atypically abundant circulating factor that protects various organs and tissues through its receptors, AdipoRs, calreticulin, T-cadherin. To identify the major binding partner of native adiponectin, we expressed these receptors on surface HEK293 cells. Adiponectin, either in mouse or human serum, purified from produced by mammalian cells, bound to cells expressing T-cadherin, but not those AdipoR1 calreticulin. The stable introduction T-cadherin into CHO...
Abstract Adiponectin (APN), a protein abundantly secreted from adipocytes, has been reported to possess beneficial effects on cardiovascular diseases in association with its accumulation target organs and cells by binding T-cadherin. However, little is known about the role of APN development diabetic microvascular complications, such as retinopathy (DR). Here we investigated impact progression early retinal vascular damage using streptozotocin (STZ)-induced mouse model. Our...
Significance Infiltration of immune cells into adipose tissue has been observed in obesity, but, until now, these data were based on immunohistological microscopic analysis. Here, to our knowledge for the first time, we applied an intravital multiphoton imaging technique with lysozyme M-EGFP transgenic (LysM EGFP ) mice whose was expressed myelomonocytic lineage. Mobility LysM -positive macrophages activated just 5 d after high-fat and high-sucrose (HF/HS) diet before development obesity....
Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been shown to possess pleiotropic effects including body weight reduction. However, long-term effect of liraglutide on and glycemic control not elucidated in Japanese type 2 diabetes (T2D) subjects. Present study investigates whether treatment maintains the weight-decreasing glucose-lowering for years T2D subjects.The enrolled subjects were 86 patients [age; 59.8 ± 12.8 years, duration diabetes; 15.8 9.5 glycated hemoglobin...
Exosomes, extracellular vesicles (EVs) produced within cells, mediate both the disposal of intracellular waste and communication with distant they are involved in a variety disease processes. Although modifications exosome cargos have been well studied, it has poorly investigated how processes, such as endoplasmic reticulum (ER) stress, affect EV production. We previously reported that adiponectin, an adipocyte-secreted salutary factor, increases systemic levels through T-cadherin-mediated...
Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine to xanthine and uric acid, respectively. However, the underlying mechanisms of increased plasma XOR its pathological roles in systemic diseases, such as atherosclerosis, are not fully understood. In this study, we found changes activity after bariatric surgery closely associated with those liver enzymes, but BMI. a mouse model nonalcoholic fatty disease/steatohepatitis (NAFLD/NASH), markedly increased. Besides, purine...
At the beginning of 2020, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) led to epidemics worldwide. Obesity and visceral fat accumulation have been reported be independent risk factors for COVID-19. Several reports focused on levels adipocytokines/adipokines, including adiponectin (APN), which is exclusively secreted from adipocytes, although importance these in conditions remains unclear. Therefore, we investigated relationship between serum...
Psychological stress is known to have a negative effect on large number of skin diseases. However, there little research the relationship between psychological and epidermal permeability barrier function (EPBF) healthy individuals. We hypothesize that deteriorates EPBF aimed investigate this relationship.Psychological was assessed using salivary alpha-amylase (sAmy; KIU L(-1) ), chromogranin A level corrected with total protein (CgAP; pmol mg(-1) protein) as biomarkers. Measurements were...
Visceral fat accumulation is a major etiological factor in the progression of type 2 diabetes mellitus and atherosclerosis. We described previously visceral multiple cardiovascular risk factors considerable number Japanese non-obese subjects (BMI <25 kg/m2). Here, we investigated differences systemic arteriosclerosis, serum adiponectin concentration, eating behavior diabetic patients with without accumulation. The study were 75 (age: 64.8 ± 11.5 years, mean SD). represented an estimated area...
A disintegrin and metalloproteinase (ADAM)12 is considered to promote cardiac dysfunction based on the finding that a small-molecule ADAM12 inhibitor, KB-R7785, ameliorated function in transverse aortic constriction (TAC) model by inhibiting proteolytic activation of heparin-binding-EGF signaling. However, this compound has poor selectivity for ADAM12, role not yet been investigated using genetic loss-of-function mice. We revealed knockout mice showed significantly more advanced hypertrophy...
Metabolic and bariatric surgery (MBS) has been established to provide long-term weight loss in severe obesity. In this study, we investigated the factors that affect post-operative loss, with a particular focus on changes eating behaviors.Time-course body behaviors were examined 49 Japanese patients who underwent laparoscopic sleeve gastrectomy from first visit 12 months after surgery. Each behavior was evaluated via questionnaire of Japan Society for Study Obesity.Pre-operative reduction...