A5025204867- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemophilia Treatment and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Orthopedic Surgery and Rehabilitation
- Trauma and Emergency Care Studies
- Elbow and Forearm Trauma Treatment
- Facial Rejuvenation and Surgery Techniques
- Orthodontics and Dentofacial Orthopedics
- Shoulder Injury and Treatment
- Cancer-related gene regulation
- Hemostasis and retained surgical items
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gastric Cancer Management and Outcomes
- Lipid metabolism and disorders
- Christian Theology and Mission
- Gastrointestinal Tumor Research and Treatment
- Vitamin K Research Studies
- Blood transfusion and management
- Religion and Society Interactions
- Renin-Angiotensin System Studies
- Diabetes Treatment and Management
- Chronic Myeloid Leukemia Treatments
- Hepatitis C virus research
- Blood properties and coagulation
Sumitomo Hospital
2011-2024
Yamamoto Hospital
2019-2024
Tottori University
2024
Saitama Medical University
2016-2023
Social Insurance Saitama Chuo Hospital
2016-2023
National Blood Transfusion Service
2023
Toyonaka Municipal Hospital
2011-2019
Saga Medical School Hospital
2018
Saga Prefectural Education Center
2018
Taisho Pharmaceutical (Japan)
2008-2018
Although elevated plasma plasminogen activator inhibitor 1 (PAI-1) is associated with obesity, very little known about its tissue or cellular origin, the events that lead to increased PAI-1 levels under obese conditions. Since TNF-alpha in rodents both during obesity and response endotoxin treatment, we examined effects of these agents on gene expression adipose CB6 mice. In untreated mice, mRNA was detected mature adipocytes stromal vascular cells. Both significantly tissue, peaking at 3-8...
Massive obstetric haemorrhage remains a major cause of maternal death attributable to hypofibrinogenaemia. Transfusion large volumes fresh frozen plasma (FFP) is required normalise fibrinogen levels. We compared the efficacy FFP (F group) with that plus concentrate + F in massive haemorrhage. In this retrospective study, we medical charts (2004-2016) 137 patients <150 mg/dl treated (n = 47; after August 2009) or 56; before 2009). Although was only administered severe cases, FFP/red blood...
Objective The aim of this study was to clarify the safety colorectal endoscopic submucosal dissection (ESD) during era health insurance coverage starting from April 2012 in Japan. Methods Between and May 2016, ESD applied 398 lesions 373 patients. Risk factors for serious complications ESD, perforation post-ESD bleeding, were evaluated focusing on resected specimen size, location, growth pattern, invasion depth, histopathology, postoperative clipping, procedure time. In addition,...
Patients with severe trauma often present critical coagulopathy, resulting in impaired hemostasis, massive hemorrhage, and a poor survival prognosis. The efficacy of hemostatic resuscitation correcting coagulopathy restoring tissue perfusion has not been studied. We assessed novel approach pre-emptive administration fibrinogen concentrate to improve patients trauma.We retrospectively compared blood transfusion volumes prognosis between three groups trauma, an Injury Severity Score (ISS) ≥26...
Repair of thoracic aortic aneurysm (TAA) is often associated with massive hemorrhage aggravated by dilutional coagulopathy severe hypofibrinogenemia. Although only fresh frozen plasma (FFP) available for acquired hypofibrinogenemia in Japan, the hemostatic effect FFP has not been enough TAA surgery. There are increasing reports suggesting that fibrinogen concentrate may be effective controlling perioperative bleeding and reducing transfusion requirements.We retrospectively analyzed compared...
A strong causal link exists between psychological stress and insulin resistance as well with hypertension. Meanwhile, stress-related responses play critical roles in glucose metabolism hypertensive patients. As clinical trials suggest that angiotensin-receptor blocker delays the onset of diabetes patients, we investigated effects irbesartan on stress-induced adipose tissue inflammation resistance. C57BL/6J mice were subjected to 2-week intermittent restraint orally treated vehicle, 3 10...
At the beginning of 2020, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) led to epidemics worldwide. Obesity and visceral fat accumulation have been reported be independent risk factors for COVID-19. Several reports focused on levels adipocytokines/adipokines, including adiponectin (APN), which is exclusively secreted from adipocytes, although importance these in conditions remains unclear. Therefore, we investigated relationship between serum...
Highly purified 125I-labeled rat renal renin (125I-renin) was given intravenously to conscious rats study the fate of circulating renin. Specific antirat antiserum used identify labeled molecules. In sham-operated rats, disappearance 125I-renin from plasma showed two exponential components with a half-life 6.7 +/- 0.4 min for rapid component and 65.1 5.7 slow component. The metabolic clearance rate 11.4 1.0 ml X min-1 kg-1. bilaterally nephrectomized reduced by 55%, but remained unchanged....
<背景・目的>手術関連死亡の最大原因は術中の大量出血であるが，その背景には外科的手技による止血が不可能な希釈性凝固障害という病態が存在する．したがって術中の大量出血を未然に防ぐには止血のための輸血治療が必要であり，その治療指針の確立が急務である．<方法・結果>術中の大量出血・大量輸血症例を後方視的に調査した結果，その60％強を胸部大動脈瘤手術，肝臓移植術，肝臓癌・肝門部癌切除術が占めていた．術中大量出血の背景にある止血不全の主要因は，出血量の増加にともなう凝固因子（特にフィブリノゲン）の喪失，枯渇であると考えられた．そこで上記症例の手術中に起こった低フィブリノゲン血症に対し，クリオプレシピテートおよびフィブリノゲン濃縮製剤の投与を行ったところ，速やかなフィブリノゲン値の上昇と止血の改善，および術中出血量・輸血量の顕著な減少（平均で30～40％減）を認めた．<結論>術中の出血量増加時には，フィブリノゲン値を確認した上で速やかにフィブリノゲン濃縮製剤を投与することが，大量出血・大量輸血を未然に防ぎ，手術患者の予後改善に大きく貢献するとともに，血液製剤の使用削減・有効利用につながると考えられた．
Ogawa H, Fujimoto Y, Yamamoto K, Hata T, Nagai S, Kamei Arikawa Nakamura Kiuchi T. Donor screening algorithm for exclusion of thrombophilia during evaluation living donor liver transplantation. Clin Transplant 2011: 25: 277–282. © 2010 John Wiley & Sons A/S. Abstract: Living transplantation (LDLT) has evolved based on the premise that safety is most important. In 2005, we encountered a who developed pulmonary embolism early post‐operative period. As it important donors to be healthy,...
Abstract We analyzed the antithrombin ( AT ) gene in four unrelated Japanese patients with an deficiency, and individually identified distinct mutations heterozygous state. There were two novel mutations, 2417delT leading to a frameshift premature termination at amino acid –3 (FS‐3Stop) C2640T resulting missense mutation (Ala59Val). Previously reported T5342C (Ser116Pro) T72C (Met‐32Thr), also found other patients. To understand molecular basis responsible for deficiency these patients,...
Abstract Many patients with coagulation disorders are infected hepatitis C virus (HCV) that advances to end stage liver disease, resulting in an increased number of deaths. The efficacy ribavirin and peginterferon combination therapy for chronic HCV infection has not been clarified fully. aim this study was evaluate the tolerability patient population compared who do have disorders. A total 226 consecutive were treated divided into two groups: (n = 23) without 203). Clinical characteristics,...
Abstract Background Limb transplantation is considered to be a treatment option for amputees. Visual skin inspection and histological assessment are used assess rejection, but these techniques largely subjective. Using rat model, we examined the potential of several microRNAs (miRNAs) as objective minimally invasive biomarkers acute rejection transplanted limbs. Methods Three Brown Norway rats 15 Lewis were assigned 2 groups. In allograft group, 3 donors 6 recipients. syngeneic (control) 9...
輸血医療に関する血液製剤使用実態調査は,国の委託事業として10年以上にわたって実施されてきた.調査開始当時のわが国の輸血医療の課題は,輸血管理体制の整備とアルブミン製剤および新鮮凍結血漿(fresh frozen plasma:FFP)の使用量削減であった.輸血管理料をはじめとする国の施策や日本輸血・細胞治療学会(学会)の認定制度によって輸血管理体制の整備は進み,それに伴って血液製剤の廃棄率も減少してきた.適正使用に関しては,輸血適正使用基準にアルブミンとFFP使用量を組み入れたことや,学会が科学的根拠に基づく血液製剤の使用ガイドラインを発表したことで,アルブミン製剤およびFFP使用量に関しては急速に減少し,今では国際的にも平均的な使用量になった.今回の調査結果の解析から,わが国の安全で適正な輸血医療の実施は明らかに進んでいると考えられる.一方で近年急速に増加してきた免疫グロブリン製剤の使用実態の評価と各血液製剤の診療科別や輸血実施場所別の使用量の把握が新たな課題である.
Although Le Fort type II, prosthesis detainment, and orthodontic treatment are considered for the management of midface retraction, they may be limited by their high cost, infection risk, excessive amount tooth movement. Therefore, Point A-Koji method was devised as a novel in patients with retraction.This is case report 26-year-old woman who presented feeling depressed protrusion mouth. Preoperatively, position lip line connecting nasal apex mental muscles (E-line) were normal, but...
Along with the increasing prevalence of obesity and related diseases, particularly atherosclerotic metabolic syndrome (MetS) is now a common major public health issue in many countries around world. Adiponectin, protein secreted by adipose tissue, has become recognized as key player development MetS. These days, not only MetS but also borderline metabolic/physiological abnormalities, such impaired fasting glucose, high normal blood pressure plasma cholesterol, have been reported to be risk...