A5003527605- SARS-CoV-2 and COVID-19 Research
- Nutritional Studies and Diet
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- Influenza Virus Research Studies
- Cervical Cancer and HPV Research
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Smoking Behavior and Cessation
- Gastroesophageal reflux and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Hepatitis B Virus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Eosinophilic Esophagitis
- Hepatitis Viruses Studies and Epidemiology
- Physical Activity and Health
- Genital Health and Disease
- Gastric Cancer Management and Outcomes
- Folate and B Vitamins Research
- Viral Infections and Immunology Research
Saga University
2016-2025
Chuo University
2025
College of Healthcare Management
2020
Saga Medical School Hospital
2005-2018
Showa University
2017
University of Occupational and Environmental Health Japan
2013-2017
Fukuoka University
2017
National Hospital for Neurology and Neurosurgery
2014
University College London
2014
Japan Clinical Cancer Research Organization
2008
Increasing attention has been paid to associations between cognitive dysfunction and brain microbleeds (MBs). Because all previous studies have investigated patients with neurological disorders, we examined subjects without disorder in order clarify pathogenic relationships.A total of 518 consecutive adults who had undergone health-screening tests the were studied prospectively. Gradient-echo T2*-weighted MRI using a 1.5-T system was used detect MBs. The Mini-Mental State Examination (MMSE)...
<h3>Objective:</h3> We investigated whether the topography of MRI-visible perivascular spaces (PVS) is associated with markers specific underlying small vessel disease, including cerebral microbleed (CMB) distribution, in neurologically healthy adults. <h3>Methods:</h3> analyzed baseline data an ongoing Japanese population-based cohort study. PVS were rated basal ganglia (BG-PVS) and centrum semiovale (CSO-PVS) on axial T2-weighted MRI using a validated rating scale (score 0–4). BG-PVS...
Abstract In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, data from a population‐based cohort study 91,738 men and women were analyzed. During 1990–1999, 422 incident cases identified. The all current smokers versus non‐smokers was 4.5 [95% confidence interval (CI): 3.0–6.8] 4.2 (95% CI: 2.4–7.2), women, respectively. When divided type, squamous cell carcinoma small 12.7 4.7–34.7) 17.5 4.9–62.1), while...
This community-based prospective study examined the effects of viral infections and lifestyle habits on hepatocellular carcinoma (HCC) risk in Japan. A baseline survey was conducted for 981 males 2,078 females June 1992 evaluated hepatitis B surface antigen, second-generation C virus antibody, history cigarette smoking habitual alcohol consumption. By March 1997, 14 8 had been newly diagnosed with HCC. After controlling gender age by using Cox model, authors found that positivity antigen...
Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment in development of lifestyle-related diseases, especially cancer, Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched 2005.Methods: We initiated a cross-sectional study examine associations genotypes with lifestyle clinical factors, as assessed by questionnaires medical examinations. The 4519 subjects were selected among...
The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus scores showed limited predictive ability for IS. Here, we investigated a newer method, polygenic score (polyGRS), based on idea that few strong signals, as well several weaker can be collectively informative determine risk.We genotyped 13 214 Japanese with 26 470 controls (derivation...
Proactive recommendations for human papillomavirus (HPV) vaccines in Japan have been suspended 5 years because of safety concerns. While no scientific evidence exists to substantiate these concerns, one reason given not reinstating is the lack reliable vaccine effectiveness (VE) data a Japanese population. This study reports VE bivalent HPV women aged 20-22 years.During cervical screening between 2014 and 2016, had Papanicolaou smears tests performed provided about their sexual history....
Type 2 Diabetes (T2D) is an emerging public health problem in Asia. Although ethnic specific mtDNA polymorphisms have been shown to contribute T2D risk, the functional effects of and therapeutic potential mitochondrial-derived peptides at are underexplored. Here, we showed Asian-specific mitochondrial DNA variation m.1382A>C (rs111033358) leads a K14Q amino acid replacement MOTS-c, insulin sensitizing peptide. Meta-analysis three cohorts (n = 27,527, J-MICC, MEC, TMM) show that males but not...
Abstract We assessed the possible association of gastrointestinal cancers with cruciferous vegetables and mushrooms in a multicenter, hospital-based case-control study an agricultural area Japan. One hundred forty-nine cases 287 controls for stomach cancer 115 230 colorectal were matched by age, sex, residential area. In cancer, protective effect (consumption total vegetable) was obscure, but it became clearer when we examined specific kinds vegetables. Marginal associations observed group...
Brain microbleeds (MBs) are considered to be associated with cognitive decline and can pathologically topographically classified as cerebral amyloid angiopathy-related (located in lobar regions) hypertensive microangiopathy-related deep regions). We examined whether different effects on global function might seen distributions of MBs.A total 1279 adults without neurological disorders were studied prospectively. Subjects divided into 4 groups: without-MBs group; both areas (diffuse group)....
Background: Dietary pattern may influence the risks of cardiovascular disease, atherosclerosis, type 2 diabetes, and metabolic syndrome through its effects on inflammation. We evaluated association between dietary serum high-sensitivity C-reactive protein (hs-CRP) in a Japanese population.Methods: In this cross-sectional analysis, we used baseline data from 3905 men 5640 women (age 40–69 years) who participated population-based cohort study November 2005 December 2007. Participants with...
National guidelines recommend trastuzumab for treatment of patients with metastatic HER2-positive gastric cancer (GC). There is currently no guideline indicating the number biopsy specimens and location from which they should be obtained to reliably determine human epidermal growth factor receptor 2 (HER2) status in GC. The aim this pilot study was (a) quantify tumor cells different regions assess spatial heterogeneity HER2 expression (b) establish required within achieve concordance between...
<b>Background and study aims</b> The aim of the present was to determine whether blue-laser imaging (BLI) reduced miss rate colon adenomatous lesions compared with conventional white-light (WLI). <b>Patients methods</b> This a prospective randomized patients undergoing screening and/or surveillance colonoscopy at Saga Medical School, Japan. A total 127 were tandem BLI followed by WLI (BLI-WLI group) or (WLI-WLI group). main outcome measure adenoma rate. <b>Results</b> proportion 62.5 % (40...
The Japanese government approved COVID-19 vaccine booster doses in November 2021. However, intentions and readiness for vaccines among the general population were unknown. This survey measured vaccination. Among 6172 participants (53.2% female), 4832 (78.3%) accepted doses; 415 (6.7%) hesitated. Vaccination intention was associated with higher age, marital status, having children, underlying diseases, social norms. To evaluate vaccination, seven component (7C) vaccination scale employed,...
Although alcohol intake as well hepatitis viruses has been associated with hepatocellular carcinoma (HCC), gene-alcohol interactions on HCC risk remain to be elucidated. We conducted a case-control study examine whether polymorphisms of dehydrogenase 2 (ADH2) and aldehyde (ALDH2) modified the depending amount intake. ADH2 ALDH2 genotyping was performed by duplex polymerase chain reaction confronting two-pair primers in 209 newly diagnosed cases different controls [275 hospital 381 patients...
Coffee use has consistently been associated with lower serum liver enzyme levels and a reduced risk of cirrhosis. A limited number cohort case‐control studies also suggest decreased hepatocellular carcinoma (HCC) among coffee drinkers, but mostly without consideration hepatitis virus infection. In the present study, we recruited 209 incident HCC cases three different controls (1308 community controls, 275 hospital 381 patients chronic disease [CLD] HCC), all whom were aged 40–79 years...
Diverticular bleeding is a common cause of lower gastrointestinal hemorrhage. Several factors, including use non-steroidal anti-inflammatory drugs (NSAIDs), antithrombotic agents and arteriosclerosis, could be risk factors. The aim this study to identify these factors.Between January 2000 December 2008, 51 patients among 178 acute hemorrhages who visited Saga Medical School were diagnosed as colonic diverticular hemorrhage, established by emergency endoscopy diagnostic criteria. Gender age...
No reports have described the immunogenicity and boosting effect of quadrivalent inactivated influenza vaccine (QIV) in adults with inflammatory bowel disease. Adults Crohn's disease or ulcerative colitis were randomly assigned to a single vaccination group booster group, QIV was administered subcutaneously. Serum samples collected before vaccination, 4 weeks after season group. In serum taken first second season. We measured hemagglutination inhibition antibody (HAI) titer calculated...
Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption European populations, no such study yet been conducted an Asian population. Here, we a GWAS to identify common variations that affected Japanese population 11,261 participants recruited as part Japan Multi-Institutional Collaborative Cohort (J-MICC) study....