Kozo Tanno
A5070727836- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Disaster Response and Management
- Heart Failure Treatment and Management
- Chronic Kidney Disease and Diabetes
- Nutritional Studies and Diet
- Dialysis and Renal Disease Management
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Liver Disease Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Health, Environment, Cognitive Aging
- Lipoproteins and Cardiovascular Health
- Posttraumatic Stress Disorder Research
- Atrial Fibrillation Management and Outcomes
- Alcohol Consumption and Health Effects
- Folate and B Vitamins Research
- Birth, Development, and Health
- Cardiovascular Function and Risk Factors
- Gout, Hyperuricemia, Uric Acid
- Sodium Intake and Health
- Frailty in Older Adults
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Geriatric Care and Nursing Homes
Iwate Medical University
2016-2025
Tohoku Medical Megabank Organization
2016-2025
Weatherford College
2022
Iwate University
2012-2019
General Department of Preventive Medicine
2011-2014
Hirosaki University
2002-2003
University of Tsukuba
1997-2001
Tokyo Medical Examiner's Office
2000-2001
Saitama Medical University
2000
Tsukuba Medical Center Hospital
2000
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
Abstract Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate rare and low-frequency variants associated with height, we construct reference panel ( N = 3,541) for genotype imputation by integrating whole-genome sequence data from 1,037 Japanese that 1000 Genomes Project, perform genome-wide association study 191,787 Japanese. We report 573 height-associated variants,...
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Aim: To examine and compare the predictive value of total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C), TC/HDL-C LDL-C/HDL-C ratios for future cardiovascular outcomes in general Japanese population.Methods: A 24,566 eligible participants aged 18 years or older, without disease, were enrolled through multiphase health screening divided into quartile groups based on levels ratios. Primary endpoints study definitive acute myocardial infarction (AMI) ischemic stroke,...
The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus scores showed limited predictive ability for IS. Here, we investigated a newer method, polygenic score (polyGRS), based on idea that few strong signals, as well several weaker can be collectively informative determine risk.We genotyped 13 214 Japanese with 26 470 controls (derivation...
Recent studies indicate that, in people with diabetes or hypertension and the general population, low-grade albuminuria (LGA) below microalbuminuria threshold is a predictor for incidence of cardiovascular disease (CVD) mortality. However, it remains unclear whether LGA predicts risk CVD death nondiabetic normotensive individuals.A total 3599 individuals aged not less than 40 years from population who are free preserved glomerular filtration rate were followed all-cause death. was defined as...
Abstract Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were in European populations. We here performed a GWAS and replication study using large Japanese cohort (9,906 cases 83,943 male controls) to identify novel susceptibility PCa risk. found 12 for including rs1125927 ( TMEM17 , P = 3.95 × 10 −16 ), rs73862213 GATA2 5.87 −23 rs77911174 ZMIZ1 5.28 −20 rs138708 SUN2 1.13 −15 seven which had crucially low...
Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines Management Hypertension. However, large-scale studies on association smoking, potassium excretion, and gamma-glutamyl transferase level with BP population are limited. We conducted a cross-sectional study to examine between risk systolic blood pressure Tohoku Medical Megabank Community-based Cohort Study (23,446 men 38,921 women aged ≥20 years). A model adjusted age, body mass...
Background. Previous studies have indicated that serum selenium levels are decreased in hemodialysis patients. Selenium deficiency may contribute to an increased risk for death among Methods. A population-based prospective cohort study adult patients was conducted. total of 1041 were enrolled. Patients divided into quartile groups according levels. Mortality rates between the compared by log-rank test. Associations and cause-specific mortality risks examined Cox's regression model. Results....
Little information is available regarding the occurrence of cerebrovascular diseases after tsunamis. This study was performed to determine influence tsunami damage caused by Great East Japan earthquake on diseases.Subjects from coastline and inland areas Iwate Prefecture who developed before disaster were included in analysis. Standardized incidence ratios 2011 against previous 3 years calculated two 4-week periods four disaster, according stroke subtype, sex, age group, flood damage.The...
Abstract Epigenome-wide association studies, which searches for blood-based DNA methylation signatures associated with environmental exposures and/or disease susceptibilities, is a promising approach to better understanding of the molecular aetiology common diseases. To carry out large-scale epigenome-wide studies while avoiding false negative detection, an efficient strategy determine target CpG sites microarray-based or sequencing-based profiling essentially needed. Here, we propose and...
Several studies have investigated the association between physical activity (PA) and all-cause mortality. However, no study has systematically examined PA changes mortality among residents of disaster-stricken areas. This aimed to clarify risk survivors Great East Japan Earthquake. At two time points from 2011 2012, 2138 men 3683 women responded a question about walking time. The cut-off value was set at 30 min, were evaluated using responses regarding over 2 years. Participants classified...
Background Natural disasters may have negative health effects on survivors. However, long-term observations this are lacking. Therefore, study investigated the association between degree of housing damage caused by Great East Japan Earthquake (GEJE) and all-cause mortality using data from cohort conducted Tohoku Medical Megabank (TMM) Project in disaster-stricken areas. Methods The community-based TMM which a baseline survey May 2013 to March 2016 collected questionnaires blood urine tests....