A5057291924- Colorectal Cancer Surgical Treatments
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Genetic Associations and Epidemiology
- Cancer Risks and Factors
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Colorectal and Anal Carcinomas
- Nutrition and Health in Aging
- Hepatitis C virus research
- Obesity, Physical Activity, Diet
- Anorectal Disease Treatments and Outcomes
- Adipose Tissue and Metabolism
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Tea Polyphenols and Effects
- Colorectal Cancer Treatments and Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Coffee research and impacts
- Global Cancer Incidence and Screening
- Folate and B Vitamins Research
Osaka University of Pharmaceutical Sciences
2021-2025
Aichi Cancer Center
2025
Nagoya University
2025
Otsu Municipal Hospital
2025
Tokai Central Hospital
2025
Saga University
2015-2024
National Cancer Center Hospital East
2024
Osaka Medical and Pharmaceutical University
2013-2022
Nagasaki International University
2021-2022
Saiseikai Fukuoka General Hospital
2000-2020
To identify the role of survivin, a novel inhibitor apoptosis (IAP) in colorectal tumorigenesis, authors investigated tissue expression survivin human tumors including 43 hyperplastic polyps, 171 adenomas with low dysplasia, 42 high and 60 carcinomas adenoma, examined whether correlated tumor cell apoptosis, proliferation, angiogenesis, which is known to initiate imbalance between proliferation apoptosis.Immunohistochemical staining for paraffin sections by using monoclonal antibodies, p53,...
Background: We pooled data from 7 ongoing cohorts in Japan involving 353 422 adults (162 092 men and 191 330 women) to quantify the effect of body mass index (BMI) on total cause-specific (cancer, heart disease, cerebrovascular disease) mortality identify optimal BMI ranges for middle-aged elderly Japanese.Methods: During a mean follow-up 12.5 years, 41 260 deaths occurred. The Cox proportional hazards model was used estimate hazard ratios (HRs) each category, after controlling age, area...
Background: Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these were mainly performed in Europeans. diverse populations have the potential to advance our understanding of CAD. Methods: We conducted 2 genome-wide for CAD Japanese population, which included 12 494 cases and 28 879 controls 2808 7261 controls, respectively. Then, we transethnic meta-analysis using results replication plus 1000 Genomes with UK Biobank. then explored...
Attention has long been drawn to the potentially harmful effects of coffee on health, however recent epidemiological studies have suggested unexpected, possibly beneficial against occurrence alcoholic liver cirrhosis and upon serum enzyme levels. We examined potential inverse association between drinking concentrations gamina-glutamyltransferase (GGT) aminotransferases, with special reference interaction alcohol consumption, in a cross-sectional study involving 12 687 health examinees (7398...
We determined the acute effects of oxidative stress on glucose uptake and intracellular signaling in skeletal muscle by incubating muscles with reactive oxygen species (ROS). Xanthine oxidase (XO) is a superoxide-generating enzyme that increases ROS. Exposure isolated rat extensor digitorum longus (EDL) to Hx/XO (Hx/XO) for 20 min resulted dose-dependent increase uptake. To determine whether mechanism leading Hx/XO-stimulated associated production H2O2, EDL from rats were preincubated H2O2...
Although a growing body of evidence suggests link between diabetes and cancer, it is not clear whether independently increases the risk cancer. We conducted comprehensive assessment association pre-existing total site-specific cancer based on pooled analysis eight cohort studies in Japan (>330 000 subjects). estimated summary hazard ratio by pooling study-specific ratios for using random-effects model. A statistically increased was observed cancers at specific sites, such as colon (hazard...
Background: Although studies suggest that exercise training improves physical performance and health-related quality of life (HRQOL) among elderly people, most these have investigated relatively healthy persons. The objective the present study was to determine effects a 12-month multicomponent program on performance, daily activity, HRQOL very people with minor disabilities.Methods: subjects consisted 65 elders (median age: 84 years) who were certified receive long-term care in form support...
Background: Most diseases are thought to arise from interactions between environmental factors and the host genotype. To detect gene–environment in development of lifestyle-related diseases, especially cancer, Japan Multi-institutional Collaborative Cohort (J-MICC) Study was launched 2005.Methods: We initiated a cross-sectional study examine associations genotypes with lifestyle clinical factors, as assessed by questionnaires medical examinations. The 4519 subjects were selected among...
The prediction of genetic predispositions to ischemic stroke (IS) may allow the identification individuals at elevated risk and thereby prevent IS in clinical practice. Previously developed weighted multilocus scores showed limited predictive ability for IS. Here, we investigated a newer method, polygenic score (polyGRS), based on idea that few strong signals, as well several weaker can be collectively informative determine risk.We genotyped 13 214 Japanese with 26 470 controls (derivation...
Type 2 Diabetes (T2D) is an emerging public health problem in Asia. Although ethnic specific mtDNA polymorphisms have been shown to contribute T2D risk, the functional effects of and therapeutic potential mitochondrial-derived peptides at are underexplored. Here, we showed Asian-specific mitochondrial DNA variation m.1382A>C (rs111033358) leads a K14Q amino acid replacement MOTS-c, insulin sensitizing peptide. Meta-analysis three cohorts (n = 27,527, J-MICC, MEC, TMM) show that males but not...
Wecomparatively investigated the extent of apoptotic cell loss in human colorectal cancers evaluated by two methods, namely conventional terminal deoxynucleotidyl transferase (TdT)‐ mediated deoxyuridine triphosphate (dUTP)‐biotin nick end‐labeling (TUNEL) method and immunohistochemistry for single‐stranded (ss) DNA. The index (AI) obtained with TUNEL was higher than that shown ssDNA. However, a significant correlation AIs these methods found. both were significantly advanced early cancers....
Abstract The roles of the hepatitis B virus (HBV), cigarette smoking and alcohol consumption in etiology hepatocellular carcinoma (HCC) were examined a case‐control study involving 204 patients with HCC 410 control subjects Fukuoka prefecture, where risk is among highest Japan. Information on drinking habits was obtained by detailed interview survey, results analyzed conjunction serum surface antigen (HBsAg) status after adjustment for sex, age other possible confounding factors. Individuals...
To objectively evaluate the benefits of laparoscopic procedures for colorectal carcinoma, a prospective study to measure stress response surgery (n = 15) compared with open 12) was undertaken. In addition, compare various parameters relevant surgical stress, major group (transthoracic esophagectomy esophageal n 4; and left upper abdominal evisceration gastric 3) assigned.Peripheral blood samples were obtained serum interleukin-6, C-reactive protein, peripheral leukocytes, lymphocyte counts....