Soichi Ogishima
A5049356235- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Biomedical Text Mining and Ontologies
- Birth, Development, and Health
- Genomics and Phylogenetic Studies
- Health, Environment, Cognitive Aging
- Pregnancy and preeclampsia studies
- Medical Imaging Techniques and Applications
- Medical and Biological Sciences
- BRCA gene mutations in cancer
- Immunotherapy and Immune Responses
- Gestational Diabetes Research and Management
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Ethics in Clinical Research
- RNA modifications and cancer
- Blood Pressure and Hypertension Studies
- Cell Adhesion Molecules Research
- Metabolomics and Mass Spectrometry Studies
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Genetics, Bioinformatics, and Biomedical Research
- Heart Rate Variability and Autonomic Control
- Genomics and Chromatin Dynamics
Tohoku Medical Megabank Organization
2016-2025
Tohoku University
2016-2025
General Department of Preventive Medicine
2024
Tohoku University Hospital
2018-2024
Center for Innovation
2020-2022
University of Edinburgh
2022
VA Boston Healthcare System
2022
The Ohio State University
2022
University College London
2020
Marie Curie
2020
Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets genes has not been previously studied en masse. Exploiting the fact active are transcribed, we simultaneously measured their activity in 19 human 14 mouse time courses covering a wide range cell types biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription factors, dominated earliest responses....
Abstract The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070 healthy Japanese individuals and construction a population reference panel (1KJPN). Here we identify through this high-coverage sequencing (32.4 × on average), 21.2 million, including 12 million novel, single-nucleotide variants (SNVs) at an estimated false discovery rate <1.0%. This detailed analysis detected signatures for purifying selection regulatory elements as well coding regions. We also...
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
Abstract We investigated whether mesenchymal stem cells (MSCs) in synovial fluid (SF) increased the knee with degenerated cartilage and osteoarthritis. SF was obtained from joints of 22 patients anterior cruciate ligament (ACL) injury during ACL reconstruction, degeneration evaluated arthroscopically. also 6 healthy volunteers, 20 mild osteoarthritis, 26 severe which grading radiographically. The cell component cultured for analyses. Synovium (SYN) bone marrow (BM) were harvested total...
Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia among elderly. To clarify pathogenesis AD, thousands reports have been accumulating. However, knowledge signaling pathways in field AD has not compiled as a database before. Description Here, we constructed publicly available pathway map called “AlzPathway” that comprehensively catalogs AD. We collected and manually curated over 100 review articles related to built an using CellDesigner. AlzPathway currently...
Background: We established a community-based cohort study to assess the long-term impact of Great East Japan Earthquake on disaster victims and gene-environment interactions incidence major diseases, such as cancer cardiovascular diseases.
Background: Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these were mainly performed in Europeans. diverse populations have the potential to advance our understanding of CAD. Methods: We conducted 2 genome-wide for CAD Japanese population, which included 12 494 cases and 28 879 controls 2808 7261 controls, respectively. Then, we transethnic meta-analysis using results replication plus 1000 Genomes with UK Biobank. then explored...
Abstract Risk factors for hypertension have been emphasized in the Japanese Society of Hypertension Guidelines Management Hypertension. However, large-scale studies on association smoking, potassium excretion, and gamma-glutamyl transferase level with BP population are limited. We conducted a cross-sectional study to examine between risk systolic blood pressure Tohoku Medical Megabank Community-based Cohort Study (23,446 men 38,921 women aged ≥20 years). A model adjusted age, body mass...
Human biomedical datasets that are critical for research and clinical studies to benefit human health also often contain sensitive or potentially identifying information of individual participants. Thus, care must be taken when they processed made available comply with ethical regulatory frameworks informed consent data conditions. To enable streamline access these datasets, the Global Alliance Genomics Health (GA4GH) Data Use Researcher Identities (DURI) work stream developed approved...
The spreading of neurofibrillary tangles (NFTs), intraneuronal aggregates highly phosphorylated microtubule-associated protein tau, across the human brain is correlated with cognitive severity Alzheimer's disease (AD). To identify genes relevant to NFT expansion defined by Braak stage, we conducted whole-genome exon array analysis an exploratory sample set consisting 213 post-mortem tissue specimens from entorinal, temporal and frontal cortices 71 brain-donor subjects: stages 0 (N=13), I-II...
The application of semantic technologies to the integration biological data and interoperability bioinformatics analysis visualization tools has been common theme a series annual BioHackathons hosted in Japan for past five years. Here we provide review activities outcomes from held 2011 Kyoto 2012 Toyama. In order efficiently implement life sciences, participants formed various sub-groups worked on following topics: Resource Description Framework (RDF) models specific domains, text mining...
The Tohoku Medical Megabank biobank (TMM biobank) is the first major population-based established in Japan. TMM was based on two population cohorts and a reconstruction program from Great East Japan Earthquake Tsunami of 2011. stores more than 3.4 million tubes biospecimens associated health analytic data obtained approximately 150,000 cohort participants between May 2013 December 2018, currently shares high-quality specimens data. Various biospecimens, including peripheral cord blood...
Abstract Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have power elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm number of 15 based on phenotypic variables from Simons Simplex Collection (SSC). As preliminary study, we conventional genome-wide association (GWAS) data set...
Abstract No study, to our knowledge, has constructed a polygenic risk score based on clinical blood pressure and investigated the association of genetic lifestyle risks with home hypertension. We examined associations combined hypertension In cross-sectional study 7027 Japanese individuals aged ≥20 years, we developed body mass index, alcohol consumption, physical activity, sodium-to-potassium ratio, categorized into ideal, intermediate, poor lifestyles. A was target data ( n = 1405) using...
Personalized healthcare (PHC) based on an individual's genetic make-up is one of the most advanced, yet feasible, forms medical care. The Tohoku Medical Megabank (TMM) Project aims to combine population genomics, genetics and prospective cohort studies develop a critical infrastructure for establishment PHC. To date, TMM CommCohort (adult general population) BirThree Cohort (birth+three-generation families) have conducted recruitments baseline surveys. Genome analyses as part will aid in...
The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This aimed to enhance precision prevention multi-factorial, complex diseases, including non-communicable and aging-associated by improving risk stratification prediction measures. At baseline, 11,002 participants aged 35–74 years were recruited City, Japan, between 2012 2015, with follow-up survey. Participants underwent various...
The purpose of this study was to report the basic profile Miyagi Prefecture part a repeated center-based survey during second period Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well participants' characteristics based on their participation type in baseline survey.
Background: The relationship between blood cell profiles, including hemoglobin (Hb) levels and inflammatory hematological ratios, mental health problems currently remains unclear. Aim: This study aimed to investigate the profiles issues, depressive state sleep disturbance, while adjusting for potential demographic confounders. Methodology: retrospective, cross-sectional, observational used a population-based medical database from Tohoku Medical Megabank Project with more than 60,000...