A5072487426- Glycosylation and Glycoproteins Research
- Genomics and Phylogenetic Studies
- Carbohydrate Chemistry and Synthesis
- Biomedical Text Mining and Ontologies
- Asymmetric Hydrogenation and Catalysis
- Genetics, Bioinformatics, and Biomedical Research
- Asymmetric Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Enzyme Production and Characterization
- Scientific Computing and Data Management
- Chemical Synthesis and Analysis
- Surface Chemistry and Catalysis
- Advanced Proteomics Techniques and Applications
- Synthetic Organic Chemistry Methods
- Enzyme Structure and Function
- Catalytic Cross-Coupling Reactions
- Research Data Management Practices
- Proteoglycans and glycosaminoglycans research
- Microbial Metabolites in Food Biotechnology
- Catalysis and Oxidation Reactions
- Advanced Battery Technologies Research
- Electric and Hybrid Vehicle Technologies
- Phosphorus compounds and reactions
- Real-time simulation and control systems
- Mesoporous Materials and Catalysis
Noguchi Institute
2016-2025
Justus-Liebig-Universität Gießen
2014
University of Georgia
2014
Macquarie University
2014
Niigata University
2014
National Institute of Advanced Industrial Science and Technology
2014
Research Organization of Information and Systems
2014
Soka University
2014
Nagoya University
2000-2001
Tokyo Metropolitan University
1996-1997
The through-space CH/π attraction between the η6 -arene ligand on Ru and carbonyl aryl substituent (see transition states in picture) plays a key role enantioselective transfer hydrogenation of aromatic compounds with 2-propanol or formic acid, catalyzed by chiral -arene-RuII complexes.
Abstract The Symbol Nomenclature for Glycans (SNFG) is a community-curated standard the depiction of monosaccharides and complex glycans using various colored-coded, geometric shapes, along with defined text additions. It hosted by National Center Biotechnology Information (NCBI) at NCBI-Glycans Page (www.ncbi.nlm.nih.gov/glycans/snfg.html). Several changes have been made to SNFG page in past year update rules depicting SNFG, include more examples use, particularly non-mammalian organisms,...
Rapid and continued growth in the generation of glycomic data has revealed need for enhanced development basic infrastructure presenting interpreting these datasets a manner that engages broader biomedical research community. Early their growth, genomic proteomic fields implemented mechanisms assigning unique gene protein identifiers were essential organizing presentation enhancing bioinformatic approaches to extracting knowledge. Similar are currently absent from data. In order facilitate...
Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover surfaces many cells, serving 'face' whereby other biomolecules viruses interact. The structure glycans, however, differs greatly from proteins in that they branched, opposed linear sequences amino acids or nucleotides. Therefore, storage glycan information databases, let alone their curation, has been a difficult problem. This caused duplicated efforts when integration is attempted between...
In recent years, the Semantic Web has become focus of life science database development as a means to link data in an effective and efficient manner. order for carbohydrate be applied this new technology, there are two requirements representations: (1) linear notation which can used URI (Uniform Resource Identifier) if needed (2) unique such that any published glycan structure represented distinctively. This latter requirement includes possible representation nonstandard monosaccharide units...
Abstract Glycans serve important roles in signaling events and cell-cell communication, they are recognized by lectins, viruses bacteria, playing a variety of many biological processes. However, there was no system to organize the plethora glycan-related data literature. Thus GlyTouCan (https://glytoucan.org) developed as international glycan repository, allowing researchers assign accession numbers glycans. This also aided integration across various databases. assigns glycans which defined...
A combined system of RuCl[(R,R)-YCH(C6H5)CH(C6H5)NH2](η6-arene) (Y = NSO2C6H4-4-CH3 or O) and t-C4H9OK catalyzes the asymmetric transfer hydrogenation various benzaldehyde-1-d derivatives with 2-propanol to yield (R)-benzyl-1-d alcohols in 95−99% ee >99% isotopic purity. Reaction benzaldehydes a DCO2D-triethylamine mixture R,R catalyst affords S deuterated 97−99% ee.
The application of semantic technologies to the integration biological data and interoperability bioinformatics analysis visualization tools has been common theme a series annual BioHackathons hosted in Japan for past five years. Here we provide review activities outcomes from held 2011 Kyoto 2012 Toyama. In order efficiently implement life sciences, participants formed various sub-groups worked on following topics: Resource Description Framework (RDF) models specific domains, text mining...
Abstract Motivation: Over the last decades several glycomics-based bioinformatics resources and databases have been created released to public. Unfortunately, there is no common standard in representation of stored information or a machine-readable interface allowing groups easily extract cross-reference information. Results: An international group experts field glycomics worked together create Resource Description Framework (RDF) for data, focused on glycan sequences related biological...
Accurate representation of structural ambiguity is important for storing carbohydrate structures containing varying levels in the literature and databases. Although many representations carbohydrates have been developed past, a generalized but discrete format did not exist. We had previously Web3 Unique Representation Carbohydrate Structures (WURCS) an attempt to define generalizable unique linear structures. However, it lacked sufficient rules uniquely describe ambiguous In this work, we...
Die CH/π-Wechselwirkung durch den Raum zwischen dem η6-gebundenen Arenliganden am Ru-Zentrum und Carbonylsubstituenten (siehe Übergangszustände im Bild) ist entscheidend für die enantioselektive Transferhydrierung aromatischer Carbonylverbindungen mit 2-Propanol oder Ameisensäure, chirale η6-Aren-RuII-Komplexe katalysiert wird. Supporting information for this article is available on the WWW under http://www.angewandte.com or from author. Please note: The publisher not responsible content...
Abstract Background Glycoscience is a research field focusing on complex carbohydrates (otherwise known as glycans) , which can, for example, serve “switches” that toggle between different functions of glycoprotein or glycolipid. Due to the advancement glycomics technologies are used characterize glycan structures, many databases now publicly available and provide useful information glycoscience research. However, these have almost no link other life science databases. Results In order...
GlyTouCan version 1.0 was released in 2015 as the international glycan structure repository, and a new sequence format called WURCS (Web3 Unique Representation of Carbohydrate Structures) proposed during early stages project. uses its base representation for glycans because existing formats were insufficient their flexibility to represent any all universally. Therefore, order obtain strings or structures, conversion tools editors that can export became necessary. GlycanBuilder an obvious...
Abstract Nonulosonic acids or non-2-ulosonic (NulOs) are an ancient family of 2-ketoaldonic (α-ketoaldonic acids) with a 9-carbon backbone. In nature, these monosaccharides occur either in 3-deoxy form (referred to as “sialic acids”) 3,9-dideoxy “sialic-acid-like” form. The former sialic most common the deuterostome lineage, including vertebrates, and mimicked by some their pathogens. latter sialic-acid-like molecules found bacteria archaea. NulOs often prominently positioned at outermost...
The glycosylation of proteins and lipids is known to be closely related the mechanisms various diseases such as influenza, cancer, muscular dystrophy. Therefore, it has become clear that analysis post-translational modifications proteins, including glycosylation, important accurately understand functions each protein molecule interactions among them. In order conduct large-scale analyses more efficiently, essential promote accumulation, sharing, reuse experimental analytical data in...
Glycans are biomolecules that take an important role in the biological processes of living organisms. They form diverse, complicated structures such as branched and cyclic forms. Web3 Unique Representation Carbohydrate Structures (WURCS) was proposed a new linear notation for uniquely representing glycans during GlyTouCan project. WURCS defines rules complex glycan other text formats did not support, so it is possible to represent wide variety glycans. However, uses nomenclature,...
Journal Article Accepted manuscript Meeting report of the GlySpace alliance and GaLSIC symposium Get access Kiyoko F Aoki-Kinoshita, Aoki-Kinoshita Glycan Life Systems Integration Center (GaLSIC), Soka University, Tokyo 192-8677, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederique Lisacek, Lisacek SIB Swiss Institute Bioinformatics & Computer Science Department, University Geneva, Switzerland Raja Mazumder, Mazumder The Department Biochemistry...
The novel chiral phosphinediamine ligand (PN2) having two amino units has been readily prepared from (S)-1-phenylethylamine derivatives and dichlorophosphine. In the hydrogenation of acrylic acids by a rhodium–PN2 catalyst, high enantioselectivities were achieved effective field formed through selective P-N chelation electrostatic interaction between unit carboxy substrate.
Abstract Recent years have seen great advances in the development of glycoproteomics protocols and methods resulting a sustainable increase reporting proteins, their attached glycans glycosylation sites. However, only very few these reports find way into databases or data repositories. One major reasons is absence digital standard to represent glycoproteins challenging annotations with glycans. Depending on experimental method, such must be able as complete structures compositions, store not...
Abstract The GlyCosmos Glycoscience Portal (https://glycosmos.org) and PubChem (https://pubchem.ncbi.nlm.nih.gov/) are major portals for glycoscience chemistry, respectively. is a portal glycan-related repositories, including GlyTouCan, GlycoPOST, UniCarb-DR, as well data resources that have been integrated from variety of ‘omics databases. Glycogenes, glycoproteins, lectins, pathways, disease information related to glycans accessible GlyCosmos. PubChem, on the other hand, chemistry-based at...