A5027874186- GDF15 and Related Biomarkers
- Chemical Synthesis and Characterization
- Nutrition and Health in Aging
- Adsorption and biosorption for pollutant removal
- Bacterial Genetics and Biotechnology
- Mitochondrial Function and Pathology
- Dietary Effects on Health
- Advanced Glycation End Products research
- Radioactive element chemistry and processing
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Minerals Flotation and Separation Techniques
- Genetics, Aging, and Longevity in Model Organisms
- Theoretical and Computational Physics
- Growth Hormone and Insulin-like Growth Factors
- Phosphorus and nutrient management
- ATP Synthase and ATPases Research
- Stochastic processes and statistical mechanics
- Heat shock proteins research
- Protein Structure and Dynamics
- Mechanisms of cancer metastasis
- Cancer, Hypoxia, and Metabolism
- Microbial Metabolic Engineering and Bioproduction
University of Southern California
2015-2025
USC Norris Comprehensive Cancer Center
2018-2025
Ajou University
2018-2025
University of California System
2016-2021
Karolinska Institutet
2014-2020
Catholic University of Pusan
2015-2018
Korea Advanced Institute of Science and Technology
2010-2017
Jeju National University
2015-2017
Pukyong National University
2017
Human Longevity (United States)
2016-2017
Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety chemotherapy drugs. Here, we show that treatment with conditions sensitized yeast cells (Saccharomyces cerevisiae) expressing oncogene-like RAS2(val19) to oxidative stress 15 17 mammalian cancer cell lines chemotherapeutic agents. Cycles were as effective agents in delaying progression different tumors increased effectiveness these drugs against melanoma, glioma,...
Strategies to treat cancer have focused primarily on the killing of tumor cells. Here, we describe a differential stress resistance (DSR) method that focuses instead protecting organism but not cells against chemotherapy. Short-term starved S. cerevisiae or lacking proto-oncogene homologs were up 1,000 times better protected oxidative chemotherapy drugs than expressing oncogene homolog Ras2 val19 . Low-glucose low-serum media also primary glial six different rat and human glioma...
Short-term fasting (48 hours) was shown to be effective in protecting normal cells and mice but not cancer against high dose chemotherapy, termed Differential Stress Resistance (DSR), the feasibility effect of patients undergoing chemotherapy is unknown. Here we describe 10 cases which diagnosed with a variety malignancies had voluntarily fasted prior (48-140 and/or following (5-56 chemotherapy. None these patients, who received an average 4 cycles various drugs combination fasting, reported...
Abstract Inhibitors of the insulin-like growth factor-I (IGF-I) receptor have been widely studied for their ability to enhance killing a variety malignant cells, but whether IGF-I signaling differentially protects host and cancer cells against chemotherapy is unknown. Starvation can protect mice, not high-dose [differential stress resistance (DSR)]. Here, we offer evidence that reduction mediates part starvation-dependent DSR. A 72-hour fast in mice reduced circulating by 70% increased level...
Mitochondria are key players in aging and the pathogenesis of age-related diseases. Recent mitochondrial transcriptome analyses revealed existence multiple small mRNAs transcribed from DNA (mtDNA). Humanin (HN), a peptide encoded mtDNA 16S ribosomal RNA region, is neuroprotective factor. An silico search six additional peptides same region as humanin; we named these humanin-like (SHLPs). We identified functional roles for potential mechanisms action. The SHLPs differed their ability to...
Abstract Healthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief organelles with strong implications in that also coordinate broad physiological functions, part, using peptides encoded within their independent genome. However, mitochondrial-encoded factors actively regulate unknown. Here, we report MOTS-c significantly enhance performance young (2 mo.), middle-age (12 old (22 mo.) mice. (i) nuclear genes, including those related to metabolism...
Background Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly invasive angiogenic tumor, resulting in 12 to 15 months median survival. The treatment of multimodal includes surgical resection, followed by adjuvant radio-and chemotherapy. We have previously reported that short-term starvation (STS) enhances therapeutic index chemo-treatments differentially protecting normal cells against...
<ns4:p>Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging increase healthy lifespan in various model organisms, ranging from unicellular yeast worms, flies, rodents, primates. However, caloric restriction, which cases entails a 20–40% reduction of food consumption relative normal intake, severe that results both beneficial detrimental effects. Specific types chronic, intermittent, or periodic restrictions without chronic have instead...
Aging is influenced by endocrine pathways including the growth hormone/insulin-like factor-1 (GH/IGF) axis. Mitochondrial function has also been linked to aging process, but relevant mitochondrial signals mediating effects of mitochondria are poorly understood. Humanin a novel signaling peptide that acts as potent regulator cellular stress responses and protects from variety in vitro vivo toxic metabolic insults. The circulating levels humanin decline with age mice humans. Here, we...
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show dexamethasone (Dexa) rapamycin (Rapa), commonly administered to patients, elevate sensitize cardiomyocytes the drug doxorubicin (DXR). Such toxicity can be reversed by reducing circulating fasting or insulin. Furthermore, injections alone fasting-dependent protection DXR mice, indicating elevated mediates, at least part, sensitizing...
Other SectionsABSTRACTINTRODUCTIONMITOCHONDRIAL GENOMIC INSTABILITY AND AGINGCELL-AUTONOMOUS MITOCHONDRIAL COMMUNICATION AGINGNON-CELL AUTONOMOUS AGINGCONCLUSIONACKNOWLEDGEMENTSCONFLICTS OF INTERESTFIGUREREFERENCES