A5083812471- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Peptidase Inhibition and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacology and Obesity Treatment
- Lipoproteins and Cardiovascular Health
- Hormonal Regulation and Hypertension
- Bariatric Surgery and Outcomes
- GDF15 and Related Biomarkers
- Sirtuins and Resveratrol in Medicine
- Diabetes Management and Education
- Amyotrophic Lateral Sclerosis Research
- Blood Pressure and Hypertension Studies
- Genetic and Kidney Cyst Diseases
- Circadian rhythm and melatonin
- Neuroendocrine Tumor Research Advances
- Endoplasmic Reticulum Stress and Disease
- Coaching Methods and Impact
University of Ulsan
2019-2025
Asan Medical Center
2019-2025
Ulsan College
2019-2025
Columbia University
2023
University School
2023
Seoul National University
2015-2021
Seoul National University Hospital
2015-2018
Seoul National University Bundang Hospital
2012-2017
MizMedi Hospital
2010
A primary cilium is an antenna-like structure on the cell surface that plays a crucial role in sensory perception and signal transduction. Mitochondria, 'powerhouse' of cell, control survival, death. The cellular ability to remove dysfunctional mitochondria through mitophagy important for survival. We show here mitochondrial stress, caused by respiratory complex inhibitors excessive fission, robustly stimulates ciliogenesis different types cells including neuronal cells. Mitochondrial...
Context: There is a substantial interindividual variation in the association between glycated hemoglobin (HbA1c) and plasma glucose concentrations.Its impact on cardiovascular disease (CVD) has not been comprehensively evaluated.Objective: We examined associations variations HbA1c, which was estimated as glycation index (HGI), CVD.Design, Setting, Participants: performed cross-sectional analysis with 1248 treatmentnaïve subjects prediabetes or diabetes.The HGI defined measured HbA1c minus...
Abstract Hypothalamic neurons including proopiomelanocortin (POMC)-producing regulate body weights. The non-motile primary cilium is a critical sensory organelle on the cell surface. An association between ciliary defects and obesity has been suggested, but underlying mechanisms are not fully understood. Here we show that inhibition of ciliogenesis in POMC-expressing developing hypothalamic neurons, by depleting ciliogenic genes IFT88 KIF3A, leads to adulthood mice. In contrast, adult-onset...
Mitochondria are principal metabolic organelles that increasingly unveiled as immune regulators. However, it is currently not known whether mitochondrial-encoded peptides modulate T cells to induce changes in phenotype and function. In this study, we found MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) prevented autoimmune β cell destruction by targeting non-obese diabetic (NOD) mice. ameliorated development hyperglycemia reduced islet-infiltrating cells. Furthermore,...
Abstract Nicotinamide adenine dinucleotide (NAD + ) is an essential cofactor of critical enzymes including protein deacetylase sirtuins/SIRTs and its levels in mammalian cells rely on the nicotinamide phosphoribosyltransferase (NAMPT)-mediated salvage pathway. Intracellular NAMPT (iNAMPT) secreted found blood as extracellular (eNAMPT). In liver, iNAMPT−NAD axis oscillates a circadian manner regulates cellular clockwork. Here we show that hypothalamic NAD distinct fluctuation with nocturnal...
Progranulin (PGRN) is a secretory precursor protein composed of 7.5 granulins (GRNs). Mutations in the PGRN-encoding gene Grn have been associated with neurodegenerative diseases. In our previous study, we found that depletion microglia disrupted glucose metabolism mice fed normal chow diet (NCD) but prevented development obesity on high-fat (HFD). Given PGRN regulates lysosomal functions, investigated changes hypothalamus microglia-specific depletion. Here report affects lysosomes...
5´-Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a cellular energy sensor, is an essential enzyme that helps cells maintain stable levels during metabolic stress. The hypothalamus pivotal in regulating balance within the body. Certain neurons are sensitive to fluctuations food availability and stores, triggering adaptive responses preserve systemic equilibrium. AMPK, expressed these hypothalamic neurons, instrumental regulatory processes. Hypothalamic AMPK activity modulated...
To investigate the effects of sunitinib treatment on blood glucose levels in patients with metastatic renal cell carcinoma. We reviewed records 48 who received for carcinoma between April 2007 and December 2010 at our institution. Patients' data including diabetic status, diabetes mellitus medication mean before, during after were assessed. In 10 (20.8%) diabetic, level was observed to be significantly decreased 4 weeks decrease being 76.1 ± 29.0 mg/dl (P = 0.002). Subsequently, a 2-week...
PERK is a pancreatic endoplasmic reticulum (ER) kinase. Its complete deletion in β cells induces insulin deficiency; however, the effects of partial Perk suppression are unclear. We investigated effect using specific inhibitors GSK2606414 and GSK2656157. Low-dose treatment for 24 h enhanced glucose-stimulated secretion (GSIS), islet content calcium transit mouse (at 40 nM) human 50-100 islets. also induced expression ER chaperone BiP release from ER. When Bip was inhibited siRNA,...
Nicotinamide adenine dinucleotide (NAD)+ serves as a crucial coenzyme in numerous essential biological reactions, and its cellular availability relies on the activity of nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed salvage pathway. Here we show that treatment with saturated fatty acids activates NAD+ pathway hypothalamic astrocytes. Furthermore, inhibition this mitigates inflammation attenuates development obesity male mice fed high-fat diet (HFD). Mechanistically, CD38 functions...
Background and Objectives:A relationship between renin-angiotensin system (RAS) components metabolic syndrome (MetS) has been suggested, but not elucidated clearly.We examined the levels of RAS in patients with without MetS their association Korean population.Methods: This study was approved by review boards participating institutions endorsed Society Lipid Atherosclerosis.We screened 892 Koreans aged ≥20 years who underwent evaluation hypertension, diabetes, or dyslipidemia at 6 tertiary...
Recently, the duodenum has garnered interest for its role in treating metabolic diseases, including type 2 diabetes (T2DM). Multiple sessions of external photobiomodulation (PBM) previous animal studies suggested it resulted improved hyperglycemia, glucose intolerance, and insulin resistance with a multifactorial mechanism action, despite target organ PBM not being clearly proven. This study aimed to determine whether single session duodenal light-emitting diode (LED) may impact T2DM...
Subjects with normal glucose tolerance (NGT) who have a high 1-hour postload plasma level (≥155 mg/dL; NGT 1 hour-high) been shown to be at higher risk for type 2 diabetes than subjects hour-low (<155 mg/dL). We compared β-cell function in hour-high, hour-low, and impaired (IGT).We classified into (n=149), hour-high (n=43), IGT (n=52). The was assessed based on insulinogenic index (IGI), oral disposition (DI), insulin secretion-sensitivity index-2 (ISSI-2).Insulin sensitivity comparable...