A5047012149- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Pain Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Nerve injury and regeneration
- Ion Channels and Receptors
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Amino Acid Enzymes and Metabolism
- Neurological disorders and treatments
- Neuropeptides and Animal Physiology
- Circadian rhythm and melatonin
- Biochemical effects in animals
- RNA regulation and disease
- Adenosine and Purinergic Signaling
- Retinal Development and Disorders
- GABA and Rice Research
- Olfactory and Sensory Function Studies
Institute for Basic Science
2018-2025
Korea University of Science and Technology
2016-2025
Gangneung–Wonju National University
2025
Korea Institute of Science and Technology
2015-2024
Korea Brain Research Institute
2024
Kyungpook National University
2024
Eli Lilly (United States)
2024
University of Science and Technology
2024
Daejeon University
2024
Seattle University
2024
Tonic Inhibition Neuronal inhibition has recently drawn much attention; however, the mechanisms involved in tonic release of and cellular source neurotransmitter involved, γ-aminobutyric acid (GABA), have been difficult to pin down. Lee et al. (p. 790 , published online 23 September) showed that GABA cerebellum occurs through Bestrophin 1 anion channel cerebellar astrocytes Bergmann glial cells. These results confirm glia can serve as a for neurons provide more evidence interactions between...
There has been a growing need for in vitro models of neurodegenerative diseases such as Alzheimer's disease that would enable better understanding etiology and faster development treatment strategies. However, meeting this demand held back by the limited ability to mimic vivo microenvironment an system. Here, we developed microfluidic chip based on three-dimensional (3D) neurospheroids more closely mimics brain providing constant flow fluid is readily observed interstitial space brain....
Joungha Won, Solji Lee, Myungsun Park, Tai Young Kim, Mingu Gordon Byung Yoon Choi, Dongwan Hyeshik Chang, V. Narry Kim and C. Justin Lee. Exp Neurobiol 2020;29:107-19. https://doi.org/10.5607/en20009
Abstract SARS-CoV-2 is very contagious and has rapidly spread globally. Due to various symptomatic asymptomatic cases the possibility of transmission, there a pressing need for fast sensitive detection protocol diagnose people. Various diagnostic kits are already available from many companies national health agencies. However, publicly information on these lacking. In response growing lack information, we developed made low-cost, easy-access, real-time PCR-based early virus in previous...
Monoamine oxidase-B (MAO-B) has recently emerged as a potential therapeutic target for Alzheimer's disease (AD) because of its association with aberrant γ-aminobutyric acid (GABA) production in reactive astrocytes. Although short-term treatment irreversible MAO-B inhibitors, such selegiline, improves cognitive deficits AD patients, long-term treatments have shown disappointing results. We show that prolonged selegiline fails to reduce astrocytic GABA levels and rescue memory impairment...
Nitric oxide (NO) has been proposed to act as a retrograde messenger during long-term potentiation (LTP) in the CA1 region of hippocampus, but inaccessibility presynaptic terminal prevented definitive test this hypothesis. Because both sides synapse are accessible cultured hippocampal neurons, we have used preparation investigate role NO. We examined LTP following intra- or extracellular application an NO scavenger, inhibitor synthase, and membrane-impermeant donor that releases only upon...
ATP has been proposed to mediate synaptic transmission in the spinal cord dorsal horn, particularly pathway carrying nociceptive information. Using transverse slices from postnatal rats, we show that EPSCs mediated by P2X receptors, and presumably activated synaptically released ATP, are evoked a subpopulation of lamina II neurons, region known receive strong input primary afferents. The receptors on acutely dissociated horn neurons nondesensitizing, insensitive alphabeta methylene but...
Amphetamine (AMPH) is known to raise extracellular dopamine (DA) levels by inducing stimulation-independent DA efflux via reverse transport through the transporter and inhibiting re-uptake. In contrast, recent studies indicate that AMPH decreases stimulation-dependent vesicular release. One candidate mechanism for this effect AMPH-mediated redistribution of from vesicles cytosol. addition, inhibition release may occur because D2 autoreceptor activation released transport. We used receptor...
Astrocytes express a wide range of G-protein coupled receptors that trigger release intracellular Ca2+, including P2Y, bradykinin and protease activated (PARs). By using the highly sensitive sniffer-patch technique, we demonstrate activation P2Y receptors, all stimulate glutamate from cultured or acutely dissociated astrocytes. Of these have utilized PAR1 as model system because favourable pharmacological molecular tools, its prominent expression in astrocytes high relevance to...
We present the MRI features with pathologic correlation of aggressive fibromatosis, incorporating 203 cases over a 5-year period from Royal Marsden Hospital Sarcoma Unit database.Sixty patients had imaging available for retrospective review which 29 preoperative and final histopathologic diagnosis fibromatosis.The average age at was 41.3 years female-to-male sex ratio 1.2:1. Twenty lesions were extraabdominal; six, intraabdominal; three, in abdominal wall (classic desmoid). The tumor size...
Receptors for the serine protease thrombin and lysophospholipids are coupled to G proteins control a wide range of cellular functions, including mitogenesis. Activators these receptors present in blood, can enter brain during central nervous system (CNS) injury. Reactive astrogliosis, prominent component CNS injury with potentially harmful consequences, may involve proliferation astrocytes. In this study, we have examined expression activation activated (PARs), lysophosphatidic acid (LPA)...
Calcium signaling is important in many processes cancer cell proliferation and motility including deadly glioblastomas of the brain that aggressively invade neighboring tissue. We hypothesized disturbing Ca(2+) pathways might decrease invasive behavior giloblastoma, extending survival. Evaluating a panel small-molecule modulators signaling, we identified caffeine as an inhibitor glioblastoma motility. Caffeine, which known to activate ryanodine receptors, paradoxically inhibits increase by...
Neurons in the suprachiasmatic nucleus (SCN) are responsible for generation of circadian oscillations, and understanding how these neurons communicate to form a functional circuit is critical issue. The neurotransmitter GABA its receptors widely expressed SCN where they mediate cell-to-cell communication. Previous studies have raised possibility that can function as an excitatory transmitter adult during day, but this work controversial. In present study, we first tested hypothesis evoke...
The four <i>N</i>-methyl-d-aspartate (NMDA) receptor NR2 subunits (NR2A-D) have different developmental, anatomical, and functional profiles that allow them to serve roles in normal neuropathological situations. Identification of subunit-selective NMDA agonists, antagonists, or modulators could prove be both valuable pharmacological tools as well potential new therapeutic agents. We evaluated the potency efficacy a wide range glutamate-like compounds at NR1/NR2A, NR1/NR2B, NR1/NR2C, NR1/NR2D...