A5091201272- Spinal Cord Injury Research
- Nerve injury and regeneration
- Dysphagia Assessment and Management
- Graphene and Nanomaterials Applications
- Stroke Rehabilitation and Recovery
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Tracheal and airway disorders
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Voice and Speech Disorders
- Pluripotent Stem Cells Research
- Esophageal and GI Pathology
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Peripheral Nerve Disorders
- Neurogenetic and Muscular Disorders Research
- Infrared Thermography in Medicine
- Acute Ischemic Stroke Management
Dankook University
2016-2025
University of Ulsan
2024
Asan Medical Center
2023-2024
Ulsan College
2024
Korea Electrotechnology Research Institute
2024
Seoul National University
2024
Kwangwoon University
2023-2024
Ulsan National Institute of Science and Technology
2023-2024
Insilicogen (South Korea)
2024
Chungnam National University
2014-2018
There has been a growing need for in vitro models of neurodegenerative diseases such as Alzheimer's disease that would enable better understanding etiology and faster development treatment strategies. However, meeting this demand held back by the limited ability to mimic vivo microenvironment an system. Here, we developed microfluidic chip based on three-dimensional (3D) neurospheroids more closely mimics brain providing constant flow fluid is readily observed interstitial space brain....
Electrospinning is a simple and effective method for fabricating micro- nanofiber matrices. Electrospun fibre matrices have numerous advantages use as tissue engineering scaffolds, such high surface area-to-volume ratio, mass production capability structural similarity to the natural extracellular matrix (ECM). Therefore, electrospun matrices, which are composed of biocompatible polymers various biomaterials, been developed biomimetic scaffolds applications. In particular, graphene oxide...
Spinal cord injury (SCI) produces excess reactive oxygen species (ROS) that can exacerbate secondary and lead to permanent functional impairment. Hypothesizing cerium oxide nanoparticles (CONPs) as an effective ROS scavenger may offset this damaging effect, it is first demonstrated in vitro CONPs suppressed inducible nitric synthase (iNOS) generation enhanced cell viability of hydrogen peroxide (H2O2)-insulted cortical neurons. Next, are administered at various does (50-4000 µg mL-1) a...
Carbon nanotubes (CNTs), with their unique and unprecedented properties, have become very popular for the repair of tissues, particularly those requiring electrical stimuli. Whilst most reports demonstrated in vitro neural cell responses CNTs, few studies been performed on vivo efficacy CNT-interfaced biomaterials regeneration tissues. Thus, we report here first time functions nerve conduits transected rat sciatic nerve. Aminated CNTs were chemically tethered onto surface aligned phosphate...
In Brief Study Design. Prospective case-control study of multifidus muscle atrophy in 39 patients with unilateral lumbosacral radiculopathy and disc herniation 20 controls. Objective. To evaluate quantitatively the asymmetry muscles (herniated intervertebral disc; HIVD) by using magnetic resonance imaging (MRI). Summary Background Data. Histologic morphologic changes have been reported herniation, but there are few studies on radiculopathy. Methods. Bilateral L3–L4, L4–L5, L5–S1 levels were...
To verify the usefulness of diffusion tensor imaging (DTI) and fiber tractography (FT) compared with routine magnetic resonance (MRI) in patients cervical spinal cord injury, to clarify relationship between motor sensory impairments DTI FT parameters, we performed MRI on 10 chronic injury controls. Quantitative parameters DTI, such as fractional anisotropy (FA) apparent coefficient (ADC), were calculated for each level. imaginary crossing numbers also determined at C3 level, from C3–C6,...
Dorsal root (DR) axons regenerate in the PNS but turn around or stop at dorsal entry zone (DREZ), entrance into CNS. Earlier studies that relied on conventional tracing techniques postmortem analyses attributed regeneration failure to growth inhibitors and lack of intrinsic potential. Here, we report first vivo imaging study DR regeneration. Fluorescently labeled, large-diameter thy1 -YFPH mice elongated through a crush site, not transection grew along >1.5 mm/d with little variability....
In the field of biomedical engineering, many studies have focused on possible applications graphene and related nanomaterials due to their potential for use as scaffolds, coating materials delivery carriers. On other hand, electrospun nanofiber matrices composed diverse biocompatible polymers attracted tremendous attention tissue engineering regenerative medicine. However, combination is intriguing still challenging. present study, we fabricated M13 bacteriophage with RGD peptide displayed...
The spinal cord does not spontaneously regenerate, and treatment that ensures functional recovery after injury (SCI) is still available. Recently, fibroblasts have been directly converted into induced neural stem cells (iNSCs) by the forced expression defined transcription factors. Although iNSCs considered to be a cell source for clinical applications, their therapeutic potential has yet investigated. Here we show from mouse enhance of SCI animals. Engrafted could differentiate all neuronal...
Spinal cord injury (SCI) leads to disruption of the blood-spinal barrier, hemorrhage, and tissue edema, which impair blood circulation induce ischemia. Angiogenesis after SCI is an important step in repair damaged tissues, extent angiogenesis strongly correlates with neural regeneration. Various biomaterials have been developed promote signaling pathways, angiogenic self-assembling peptides are useful for producing diverse supramolecular structures tunable functionality. RADA16...
Mesenchymal stem cells are widely used for transplantation into the injured spinal cord in vivo model and safety, many human clinical trials continuing to promote improvements of motor sensory functions after injury. Yet exact mechanism these remains undefined. Neurogenic bladder following injury is main problem decreasing quality life patients with injury, but there no clear data using cell improvement neurogenic studies setting. The purpose this study was delineate effect mesenchymal...
Abstract A reliable source of osteogenic cells is an essential factor for bone tissue engineering. In this study, human‐induced pluripotent stem (hiPSCs) without embryoid body step were cultured in macrochanneled poly(caprolactone) (PCL) scaffolds prepared using a robotic dispensing technique, after which osteogenesis was promoted by the addition exogenous factors. The hiPSCs demonstrated based on detection molecules, such as osteopontin, flow cytometry analysis, quantitative polymerase...
Regeneration of over 10 mm long peripheral nerve defects remains a challenge due to the failure regeneration by prolonged axotomy and denervation occurring in long-term recovery. Recent studies reveal that conductive conduits electrical stimulation accelerate defects. In this study, an electroceutical platform combining fully biodegradable conduit wireless stimulator is proposed maximize therapeutic effect on regeneration. Fully fabricated using molybdenum (Mo) microparticles...
Abstract A fully biodegradable, ultra‐sensitive, and soft strain sensor is pivotal for temporary, real‐time monitoring of microdeformations, crucial in disease diagnosis, surgical precision, prognosis muscular, vascular conditions. Nevertheless, the sensitivity previous biodegradable sensors, denoted by gauge factor (GF) up to ≈100, falls short requirements complex biomedical scenarios, specifically cardio‐cerebrovascular diseases with microscale variations surface strain. Here, a...
Abstract Pressure‐sensitive adhesives are widely utilized due to their instant and reversible adhesion various dry substrates. Though offering intuitive robust attachment of medical devices on skin, currently available clinical pressure‐sensitive do not attach internal organs, mainly the presence interfacial water tissue surface that acts as a barrier adhesion. In this work, pressure‐sensitive, repositionable bioadhesive (PSB) adheres organs by synergistically combining characteristic...
Objectives: This paper’s objective was to identify clinical predictors, especially modifiable ones, associated with postoperative gait recovery in total hip arthroplasty (THA) patients, utilizing propensity score weighting (PSW) control confounding factors. Methods: retrospective cohort study included 221 patients who underwent primary unilateral THA. We used PSW analysis balance patient characteristics. Univariate and multivariate logistic regression analyses were applied determine...
BACKGROUND The optimization of tacrolimus dosing during the early postoperative hospitalization period is essential to prevent rejection, minimize nephrotoxicity, and risk opportunistic infections. Patient pharmacokinetic variability poses challenges in dose adjustment. This study aimed evaluate using machine learning statistical methods. MATERIAL AND METHODS We conducted a retrospective 749 kidney transplant recipients at Seoul St. Mary's Hospital between January 2015 December 2019. Data on...