Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT PLCγ among which pathway is known to be predominant. Several studies have recently implicated in vitro functions FGFs for tissue regeneration. However, obtain optimal outcomes vivo, it important enhance half-life their stability....

Abstract Silver nanoparticles (AgNPs) have found a variety of uses including biomedical materials; however, studies the cytotoxicity AgNPs by size effects are only in beginning stage. In this study, we examined size‐dependent cellular toxicity using three different characteristic sizes (∼ 10, 50, and 100 nm) against several cell lines MC3T3‐E1 PC12. The cytotoxic effect determined based on viability, intracellular reactive oxygen species generation, lactate dehydrogenase release,...

The development of various flexible and stretchable materials has attracted interest for promising applications in biomedical engineering electronics industries. This wearable electronics, circuits, displays created a demand stable, easily manufactured, cheap materials. However, the construction elastic on which commercial electronic components can be mounted through simple cost-effective processing, remains challenging. We have developed nanocomposite carbon nanotubes (CNTs)...

Here we communicate the development of a novel multifunctional hybrid nanomaterial, magnetic carbon nanotubes (CNTs) ensheathed with mesoporous silica, for simultaneous applications drug delivery and imaging. Magnetic nanoparticles (MNPs) were first decorated onto multiwalled CNTs, which was then layered silica (mSiO2) to facilitate loading bioactive molecules large quantity while exerting properties. The nanomaterial showed high mesoporosity due surface-layered mSiO2, excellent properties,...

Carbon nanotubes (CNTs), with their unique and unprecedented properties, have become very popular for the repair of tissues, particularly those requiring electrical stimuli. Whilst most reports demonstrated in vitro neural cell responses CNTs, few studies been performed on vivo efficacy CNT-interfaced biomaterials regeneration tissues. Thus, we report here first time functions nerve conduits transected rat sciatic nerve. Aminated CNTs were chemically tethered onto surface aligned phosphate...

Currently there is a strong need for new drug delivery systems, which enable targeted and controlled function in delivering drugs while satisfying highly sensitive imaging modality early detection of the disease symptoms damaged sites. To meet these criteria we develop system that integrates therapeutic diagnostic capabilities (theranostics). Importantly, efficacy enhanced by exploiting synergies between nanoparticles, drug, hyperthermia. At core our innovation near-infrared (NIR) responsive...

Although PMMA-based biomaterials are widely used in clinics, a major hurdle, namely, their poor antimicrobial (i.e., adhesion) properties, remains and can accelerate infections. In this study, carboxylated multiwalled carbon nanotubes (CNTs) were incorporated into poly(methyl methacrylate) (PMMA) to achieve drug-free adhesion properties. After characterizing the mechanical/surface anti-adhesive effects against 3 different oral microbial species (Staphylococcus aureus, Streptococcus mutans,...

Sensors, such as optical, chemical, and electrical sensors, play an important role in our lives. While these sensors already have widespread applications, humidity most are generally incompatible with flexible/inactive substrates rely on conventional hard materials complex manufacturing processes. To overcome this, we develop a CNT-based, low-resistance, flexible sensor. The core-shell structured CNT@CPM is prepared Chit PAMAM to achieve reliability, accuracy, consistency, durability,...

Biomimetic stress-relaxing hydrogels with reversible crosslinks attract significant attention for stem cell tissue regeneration compared elastic hydrogels. However, hyaluronic acid (HA)-based fabricated using conventional technologies lack stability, biocompatibility, and mechanical tunability. Here, it is aimed to address these challenges by incorporating calcium or phosphate components into the HA backbone, which allows crosslinking of alginate form interpenetrating networks, offering...

Abstract In the metal triflate‐catalyzed hydroarylation of alkynes, employing an ionic liquid dramatically enhanced catalytic activities, resulting in broadening scope substrates (arenes and alkynes). some cases, even reactions that were not possible conventional organic solvents proceeded smoothly liquids. Moreover, phase containing catalyst could be readily recovered by simple decantation layer after reaction reused for following runs without any significant loss activity. Mechanistic...

Responses of mesenchymal stem cells (MSCs) cultured with zinc-added (2 and 5%) bioactive glass granules were evaluated in terms cell growth osteogenic differentiation. MSCs different quantities (3, 10 30) for up to 21 days the medium. Cell was stimulated by a small quantity glasses, particularly those that contained zinc. Osteogenic differentiation, as assessed alkaline phosphatase activity (ALP) activity, significantly enhanced large prolonged culturing. Expression bone-sialo protein (BSP)...

Nanocomposite scaffolds with tailored 3D pore configuration are promising candidates for the reconstruction of bone. Here we fabricated novel nanocomposite bone through robocasting. Poly(caprolactone) (PCL)-hydroxyapatite (HA) slurry containing ionically modified carbon nanotubes (imCNTs) was robotic-dispensed and structured layer-by-layer into macrochanneled under adjusted processing conditions. Homogeneous dispersion imCNTs (0.2 wt % relative to PCL-HA) achieved in acetone, aiding...

Smart hydrogels that are responsive to various external (e.g. electrical and/or thermal) stimulation have become increasingly popular in recent years for simple, rapid, and precise drug delivery can be controlled turned on or off with stimuli. For such a switchable material, highly homogeneous dispersion distribution of the hydrophobic, electrically conductive nanomaterials throughout hydrophilic three-dimensional (3D) hydrogel network remains challenge is essential achieving well-connected...

Abstract The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been directed toward applying electricity to cells tissues through external force devices or biomaterial-based platforms. In addition situ electroconductive matrices, new class of electroactive biomaterials responsive stimuli has emerged as focal point interest. These materials,...

Tackling aromaticity: The title reaction was accomplished by simultaneous activation of molecular hydrogen and the aromatic substrate Pd/C a Lewis acidic ionic liquid, respectively. Even benzene C60 fullerene were hydrogenated under ambient conditions (1 bar H2 at room temperature). An hydrogenation mechanism (see scheme) is supported characterization stabilized arenium intermediate. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents...

Carbon nanotubes (CNTs) have an important role in nanotechnology due to their unique properties, retaining the inherent material flexibility, superior strength, and electrical conductivity, unless bottleneck of CNTs persists aggregated structure is overcome. Here, we report on highly enhanced mechanical properties CNT-chitosan nanocomposites through homogeneous dispersion into chitosan solution using a high-pressure homogenizer. The optimal condition 50% (w/w) chitosan-CNT film, providing...

The recent progress in nanoparticle applications, such as tumor-targeting, has enabled specific delivery of chemotherapeutics to malignant tissues with enhanced local efficacy while limiting side effects. However, existing systems leave much room for improvement terms achieving colloidal stability fluid medium, efficient targeting intended sites, and effective release therapeutic drugs into diseased cells. Here, an stimuli-responsive nanocarrier mammalian cells, termed RGD-NAMs, was...