A5041064140- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Asymmetric Synthesis and Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Chemokine receptors and signaling
- Advanced Nanomaterials in Catalysis
- Synthetic Organic Chemistry Methods
- Fluorine in Organic Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Venomous Animal Envenomation and Studies
- Chemical Synthesis and Reactions
- Organic Chemistry Cycloaddition Reactions
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Treatment and Research
- Dental Implant Techniques and Outcomes
- Facial Trauma and Fracture Management
- Cyclopropane Reaction Mechanisms
- Electrophoretic Deposition in Materials Science
- Glass properties and applications
- Animal Virus Infections Studies
- Crystal structures of chemical compounds
- Quantum Dots Synthesis And Properties
- Organic and Inorganic Chemical Reactions
Integra LifeSciences (United States)
2024
Dankook University
2015-2024
Indian Veterinary Research Institute
2005-2023
Dr. C. V. Raman University
2016-2023
Siksha O Anusandhan University
2023
ICAR-National Research Centre on Pig
2022
Lala Lajpat Rai University of Veterinary and Animal Sciences
2022
Indian Council of Agricultural Research
2022
Guru Angad Dev Veterinary and Animal Sciences University
2022
Indian Institute of Technology Kharagpur
2022
Sol–gel chemistry offers a flexible approach to obtaining diverse range of materials. It allows differing chemistries be achieved as well offering the ability produce wide nano-/micro-structures. The paper commences with generalized description various sol–gel methods available and how these control bulk properties end products. Following this, more detailed biomedical areas where materials have been explored found hold significant potential. One interesting fields that has developed...
Carbon-based nanomaterials emerge as promising platforms for theranostic applications in disease treatment and tissue repair.
Drug molecules with lack of specificity and solubility lead patients to take high doses the drug achieve sufficient therapeutic effects. This is a leading cause adverse reactions, particularly for drugs narrow window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible carriers available in market, which can deliver agents target site controlled manner. Among developed thus far, mesoporous materials emerged as promising candidate that variety...
Abstract The proinflammatory chemokine interleukin-8 (IL-8) is undetectable in androgen-responsive prostate cancer cells (e.g., LNCaP and LAPC-4), but it highly expressed androgen-independent metastatic cells, such as PC-3. In this report, we show IL-8 functions androgen independence, chemoresistance, tumor growth, angiogenesis. We stably transfected LAPC-4 with cDNA selected IL-8–secreting (IL8-S) transfectants. IL8-S transfectants that secreted at levels similar to by PC-3 (100–170 ng/106...
Magnetic nanofibrous scaffolds of poly(caprolactone) (PCL) incorporating magnetic nanoparticles (MNP) were produced, and their effects on physico-chemical, mechanical biological properties extensively addressed to find efficacy for bone regeneration purpose. MNPs 12 nm in diameter citrated evenly distributed PCL solutions up 20% then electrospun into nonwoven webs. Incorporation greatly improved the hydrophilicity nanofibers. Tensile nanofibers (tensile strength, yield elastic modulus...
The proinflammatory chemokine receptor CXCR7 that binds the ligands CXCL11 and CXCL12 (SDF-1a) is elevated in a variety of human cancers, but its functions are not understood as it does elicit classical signaling. Here we report procancerous cytokine IL-8 (interleukin-8) upregulates expression along with ligand-independent promote growth proliferation prostate cancer cells (CaP cells). In cell culture, ectopic or addition selectively increased at level mRNA protein production. Conversely,...
Theranostics based on nanoparticles (NPs) is a promising paradigm in nanomedicine. Mesoporous silica nanoparticle (MSN)-based systems offer unique characteristics to enable multimodal imaging or simultaneous diagnosis and therapy. They include large surface area volume, tunable pore size, functionalizable surface, acceptable biological safety. Hybridization with other NPs chemical modification can further potentiate the multifunctionality of MSN-based toward translation. Here, we update...
Here we communicate the development of a novel multifunctional hybrid nanomaterial, magnetic carbon nanotubes (CNTs) ensheathed with mesoporous silica, for simultaneous applications drug delivery and imaging. Magnetic nanoparticles (MNPs) were first decorated onto multiwalled CNTs, which was then layered silica (mSiO2) to facilitate loading bioactive molecules large quantity while exerting properties. The nanomaterial showed high mesoporosity due surface-layered mSiO2, excellent properties,...
Novel nanocomposite magnetic scaffolds demonstrated excellent bone cell responses.
Abstract Magnetic nanoparticles (MNPs) are considered highly useful in therapeutic and diagnostic applications. However, MNPs require surface modification to promote dispersibility aqueous solutions thus biocompatibility. In this article, the authors modified with inorganic silica layer create silica‐coated magnetite (MNP@Si) via sol–gel process. Synthesis involves hydrolysis condensation steps using tetraethylorthosilicate (TEOS) methanol/ polyethylene glycol (PEG) solution ammonia...
Currently there is a strong need for new drug delivery systems, which enable targeted and controlled function in delivering drugs while satisfying highly sensitive imaging modality early detection of the disease symptoms damaged sites. To meet these criteria we develop system that integrates therapeutic diagnostic capabilities (theranostics). Importantly, efficacy enhanced by exploiting synergies between nanoparticles, drug, hyperthermia. At core our innovation near-infrared (NIR) responsive...
Recent advances have revealed a significant contribution of chemokines and their receptors in tumor growth, survival after chemotherapy, organ-specific metastasis. The CXC chemokine receptor-7 (CXCR7) is the latest receptor implicated cancer. Although over expressed breast cancer cell lines tissues, its mechanism action (BrCa) growth metastasis unclear. Studies other cancers CXCR7 proliferation, anti-apoptotic activity cell-cell adhesion. present study was initiated to examine pattern...
Nanoscale scaffolds that characterize high bioactivity and the ability to deliver biomolecules provide a 3D microenvironment controls stimulates desired cellular responses subsequent tissue reaction. Herein novel nanofibrous hybrid of polycaprolactone shelled with mesoporous silica (PCL@MS) were developed. In this system, shell provides an active biointerface, while nanoscale fibrous structure cell-stimulating matrix cues suitable for bone regeneration. The electrospun PCL nanofibers coated...
Nanocarriers of bioactive glass loading BMP2 plasmid DNA are effective for the osteogenic stimulation mesenchymal stem cells and healing bone defects.