Na-Hyun Lee

ORCID: 0000-0002-0931-4378
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Research Areas
  • Bone Tissue Engineering Materials
  • Cancer Cells and Metastasis
  • Cancer-related molecular mechanisms research
  • Graphene and Nanomaterials Applications
  • Cancer, Stress, Anesthesia, and Immune Response
  • Autophagy in Disease and Therapy
  • Inflammasome and immune disorders
  • Insect and Pesticide Research
  • Endoplasmic Reticulum Stress and Disease
  • Xenotransplantation and immune response
  • Virus-based gene therapy research
  • Cancer, Hypoxia, and Metabolism
  • 3D Printing in Biomedical Research
  • Alcohol Consumption and Health Effects
  • Advanced Manufacturing and Logistics Optimization
  • Insect Pest Control Strategies
  • Modular Robots and Swarm Intelligence
  • Contact Dermatitis and Allergies
  • Wnt/β-catenin signaling in development and cancer
  • Nanoplatforms for cancer theranostics
  • Medical and Biological Ozone Research
  • Multimodal Machine Learning Applications
  • Advanced Image and Video Retrieval Techniques
  • Electrospun Nanofibers in Biomedical Applications
  • Selenium in Biological Systems

Korea Institute of Robot and Convergence
2019-2024

Kyung Hee University Hospital at Gangdong
2023-2024

Chung-Ang University
2021-2024

Seoul National University
2024

Dankook University
2018-2023

Soongsil University
2023

Ewha Womans University
2021-2022

Rural Development Administration
2021

National Institute of Animal Science
2020-2021

Konyang University
2020

Triple-negative breast cancer (TNBC) is an aggressive tumor subtype with enriched CD44+/CD24- stem-like population. Salinomycin antibiotic that has been shown to target stem cells (CSC); however, the mechanisms of action involved have not well characterized. The objective present study was investigate effect salinomycin on cell death, migration, and invasion, as CSC-like properties in MDA-MB-231 cells. significantly induced anoikis-sensitivity, accompanied by caspase-3 caspase-8 activation...

10.1371/journal.pone.0141919 article EN cc-by PLoS ONE 2015-11-03

Since the European Union (EU) announced their animal testing ban in 2013, all experiments related to cosmetics have been prohibited, creating a demand for alternatives skin studies. Here, we investigated whether an ex vivo live porcine model can be employed study safety and barrier-improving effects of hydroxyacids widely used keratolytic peels. Glycolic acid (1–10%), salicylic (0.2–2%), lactobionic (1.2–12%) were as representative substances α-hydroxyacid (AHA), β-hydroxyacid (BHA),...

10.3390/ijms22020657 article EN International Journal of Molecular Sciences 2021-01-11

Nanomaterials combined with phototherapy and multimodal imaging are promising for cancer theranostics. Our aim is to develop fluorescent mesoporous bioglass nanoparticles (fBGn) based on carbon dots (CD) delivery, triple-mode imaging, photothermal (PTT) properties A direct label-free approach was used prepare multicolor fBGn 3-aminopropyl triethoxysilane as the surface-functionalizing agent. The calcination at 400 °C provided high fluorescence intensity originating from CD. In particular, a...

10.1021/acsabm.0c00050 article EN ACS Applied Bio Materials 2020-03-02

Other SectionsABSTRACTINTRODUCTIONSPHEROID FORMATION METHODSBONE DEFECT REGENERATIONCARTILAGE REGENERATIONCRITICAL LIMB ISCHEMIA REPAIRCARDIAC REPAIRPANCREAS REGENERATIONHAIR FOLLICLE REGENERATIONFUTURE DIRECTIONSACKNOWLEDGEMENTSCONFLICTS OF INTERESTFIGURESTABLESREFERENCES

10.5483/bmbrep.2021.54.7.059 article EN cc-by-nc BMB Reports 2021-07-30

Reactive oxygen species (ROS) regulate various functions of cells, including cell death, viability, and differentiation, nanoparticles influence ROS depending on their size shape. Selenium is known to physiological functions, such as differentiations anti-inflammatory plays an important role in the regulation antioxidant. This study aims investigate effect selenium (SeNPs) differentiation osteogenic MC3T3-E1 cells. After fabrication SeNPs with a 25.3 ± 2.6 nm, confirmation its oxidase-like...

10.3390/nano11020557 article EN cc-by Nanomaterials 2021-02-23

Although the role of eosinophils in eosinophilic gastroenteritis (EGE) is not fully understood, they are believed to be a principal effector cell. Previous studies have demonstrated that eotaxin and its specific receptor, cysteine-cysteine chemokine receptor-3 (CCR3), play central eosinophil trafficking into gastrointestinal (GI) tract. Thus, we examined targeting CCR3 as potential therapeutic intervention for EGE mouse model. Eight- 10-week-old BALB/c mice were intraperitoneally sensitized...

10.4168/aair.2017.9.4.360 article EN cc-by-nc Allergy Asthma and Immunology Research 2017-01-01

Abstract Formaldehyde is a colorless, pungent, highly reactive, and toxic environmental pollutant used in various industries products. Inhaled formaldehyde human animal carcinogen that causes genotoxicity, such as reactive oxygen species formation DNA damage. This study aimed to identify the effects of inhaled through an integrated toxicogenomic approach utilizing database information. Microarray datasets (GSE7002 GSE23179) were collected from Gene Expression Omnibus database, differentially...

10.1038/s41598-022-09673-0 article EN cc-by Scientific Reports 2022-04-04

Guarea genus comprises tropical and subtropical terrestrial herbs inhabiting Central South America. These plants, including guidonia (L.) Sleumer, have anti-inflammatory, analgesic, antibacterial, antiviral, immune-enhancing properties.

10.1016/j.jep.2024.117711 article EN cc-by-nc-nd Journal of Ethnopharmacology 2024-01-03

Abstract Inflammation is implicated as a cause in many diseases. Most of the anti-inflammatory agents use are synthetic and there an unmet need for natural substance-derived with minimal side effects. Aiouea padiformis belongs to Lauraceae family primarily found tropical regions. While some members genus known possess properties, properties extract (AP) have not been investigated. In this study, we aimed examine function AP through NOD-, LRR- pyrin domain-containing protein 3 (NLRP3)...

10.1038/s41598-024-55651-z article EN cc-by Scientific Reports 2024-03-04
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