A5089140167- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Air Quality Monitoring and Forecasting
- Microbial infections and disease research
- IL-33, ST2, and ILC Pathways
- Bacterial Infections and Vaccines
- Eosinophilic Esophagitis
- Food Allergy and Anaphylaxis Research
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Emergency and Acute Care Studies
- Noise Effects and Management
- Climate Change and Health Impacts
- Influenza Virus Research Studies
- Nutrition, Health and Food Behavior
- Health and Wellbeing Research
Korea University
2015-2025
Korea University Medical Center
2016-2025
Zhejiang Chinese Medical University
2025
Konyang University Hospital
2024
Louisiana State University in Shreveport
2024
Chinese PLA General Hospital
2019
University of California, San Diego
2007-2017
Asan Medical Center
2013-2014
University of Ulsan
2014
Ulsan College
2014
Previous studies have consistently shown a significant correlation between air pollution, particularly PM 2.5 , and various diseases, as well increased mortality rates. This study introduces novel approach for predicting time‐specific indoor exposure by incorporating individual movement routes activity spaces using GPS tracking data time–activity diary. The models were trained separately each hour of the day (e.g., 0:00–0:59, 1:00–1:59) with total 24 models. Their applicability was...
Siglec-F is a sialic acid-binding Ig superfamily receptor that highly expressed on eosinophils. We have investigated whether administration of an anti-Siglec-F Ab to OVA-challenged wild-type mice would reduce levels eosinophilic inflammation and airway remodeling. Mice sensitized OVA challenged repetitively with for 1 mo who were administered had significantly reduced peribronchial subepithelial fibrosis as assessed by either trichrome staining or lung collagen levels. The the number bone...
The aim of the present study was to investigate relationship between three major allergic diseases, asthma, rhinitis (AR), and atopic dermatitis (AD), psychological behavioural problems in preschoolers based on a community survey.A cross-sectional survey conducted using modified International Study Asthma Allergies Childhood questionnaire determine prevalence symptoms diagnosed Korean version Child Behaviour Checklist assess internalizing, externalizing, sleep among 780 preschoolers....
Background Although cesarean delivery and prenatal exposure to antibiotics are likely affect the gut microbiome in infancy, their effect on development of atopic dermatitis (AD) infancy is unclear. The influence individual genotypes these relationships also To evaluate with a prospective birth cohort study whether section, antibiotics, susceptible act additively promote AD infancy. Methods Cohort for Childhood Asthma Allergic Diseases (COCOA) was selected from general Korean population. A...
Abstract Background Community–acquired pneumonia (CAP) is one of the leading worldwide causes childhood morbidity and mortality. Its disease burden varies by age etiology time dependent. We aimed to investigate annual seasonal patterns in etiologies pediatric CAP requiring hospitalization. Methods conducted a retrospective study 30,994 children (aged 0–18 years) with between 2010 2015 at 23 nationwide hospitals South Korea. Mycoplasma pneumoniae (MP) was clinically classified as...
Mycoplasma pneumoniae is a major causative pathogen of community-acquired pneumonia in children, and the treatment choice macrolides. There an increasing trend reports refractory clinical responses despite macrolide due to emergence macrolide-resistant M. pneumoniae. Early discrimination macrolide-refractory (MrMP) from macrolide-sensitive (MSMP) vital; however, testing for susceptibility at time admission not feasible. This study aimed identify characteristics MrMP Korean comparison with...
Aims. The aims of this study were (1) to determine the reference values for impulse oscillometry (IOS) and (2) apply them evaluation asthma in general population young Korean children. Methods. We performed a questionnaire survey IOS measurements 390 children aged 3–7 years Seoul Gyeonggi province, Korea, from July August 2010. included respiratory resistance (Rrs) reactance (Xrs) at 5, 10, 15, 20, 25, 35 Hz, impedance (Zrs), resonance frequency (RF) before 15 min after inhalation 200 μg...
Bat species around the world have recently been recognized as major reservoirs of several zoonotic viruses, such severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East (MERS-CoV), Nipah virus and Hendra virus. In this study, consensus primer-based reverse transcriptase polymerase chain reactions (RT-PCRs) high-throughput sequencing were performed to investigate viruses in bat faecal samples collected at 11 natural habitat sites from July December 2015 Korea. Diverse...
Air pollution is an increasing global concern, and its effect on allergic inflammation has attracted the attention of many researchers. Particulate matter (PM) a major component ambient air pollution, heavy metals are primary toxic constituents PM. As previous studies impact pollutants did not adequately mimic real-world atmospheric exposure, we developed experimental model to investigate effects aerosolized nasal epithelial cells fibroblasts.
In this study, we have examined the role of phosphoinositide 3 kinase gamma (PI3Kgamma), a class Ib PI3K, in contributing to airway remodeling utilizing PI3Kgamma-deficient mice exposed chronic allergen challenge. Wild-type (WT) sensitized ovalbumin (OVA) and chronically challenged with OVA for 1 mo developed significantly increased levels eosinophilic inflammation remodeling. contrast, had reduced numbers bronchoalveolar lavage peribronchial eosinophils compared WT mice. There was no...
Abstract Chronic asthma is associated with airway remodeling and decline in lung function. In this article, we show that follistatin-like 1 (Fstl1), a mediator not previously asthma, highly expressed by macrophages the lungs of humans severe asthma. allergen-challenged Lys-Cretg /Fstl1Δ/Δ mice whom Fstl1 inactivated macrophages/myeloid cells had significantly reduced levels oncostatin M (OSM), cytokine known to be regulated Fstl1. The importance induction OSM was demonstrated murine studies...
Despite ample research on the association between indoor air pollution and allergic disease prevalence, public health environmental policies still lack predictive evidence for developing a preventive guideline patients or vulnerable populations mostly due to limitation of real-time big data model predictability. Recent popularity IoT machine learning techniques could provide enabling technologies collecting analyzing them more accurate prediction risks evidence-based intervention, but effort...
Studies on the longitudinal clinical features of asthma or allergic comorbidities in children are limited. We aimed to examine trajectories and determine whether these differ according phenotypes from birth adolescence. enrolled 958 with physician-diagnosed Korean childhood Asthma Study (KAS) cohort. Children were classified using hierarchical cluster analysis. Information diagnosis treatment diseases before cohort entry was collected through linkage national claims data Health Insurance...
Asthma is a heterogenous disease having varied phenotypes. The comorbidities associated with asthma vary age and severity. well-known related comorbid conditions include rhinitis, gastroesophageal reflux (GERD), hypertension, obstructive sleep apnea, hormonal disorders, psychiatric disorders. However, comprehensive analyses of how severity correlates the prevalence type remain limited. Understanding these relationships essential for developing targeted management strategies. This study aims...
This study analyzed the factors influencing personal PM2.5 exposure levels among adults with allergic diseases in Seoul using a linear mixed-effects (LMEs) model. The average concentration of participants was 17.38 μg/m3, exceeding World Health Organization (WHO) daily recommended guideline (15.00 μg/m3), though it relatively low compared to global levels. Inter-individual variability approximately 43.5%, varying significantly depending on microenvironments. Notably, 58% exhibited higher...
Purpose Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim present study was to examine influence 25(OH)D concentrations on infant RTI a Korean birth cohort. Methods levels obtained from 525 newborns prospective COhort for Childhood Origin Asthma and allergic diseases were examined. primary outcome variable interest prevalence at 6-month follow-up, as...
Although the role of eosinophils in eosinophilic gastroenteritis (EGE) is not fully understood, they are believed to be a principal effector cell. Previous studies have demonstrated that eotaxin and its specific receptor, cysteine-cysteine chemokine receptor-3 (CCR3), play central eosinophil trafficking into gastrointestinal (GI) tract. Thus, we examined targeting CCR3 as potential therapeutic intervention for EGE mouse model. Eight- 10-week-old BALB/c mice were intraperitoneally sensitized...
The prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) has increased worldwide. aim this study was to estimate the proportion MRMP in a tertiary hospital Korea, and find potential laboratory markers that could be used predict efficacy macrolides children with pneumonia.A total 95 patients M. pneumonia were enrolled study. Detection based on results specific point mutations domain V 23S rRNA gene. medical records these reviewed retrospectively clinical course data compared.The...