A5101755051- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Contact Dermatitis and Allergies
- Noise Effects and Management
- Ocular Surface and Contact Lens
- Air Quality and Health Impacts
- Immune Response and Inflammation
- Indoor Air Quality and Microbial Exposure
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Antimicrobial agents and applications
- Plant Reproductive Biology
- Microscopic Colitis
- Air Quality Monitoring and Forecasting
- Vitamin C and Antioxidants Research
- Antimicrobial Peptides and Activities
- Exercise and Physiological Responses
- Plant-Microbe Interactions and Immunity
- Occupational exposure and asthma
Seoul National University Hospital
2021
Seoul National University
2013-2021
Asan Medical Center
2013-2020
CHA Bundang Medical Center
2014-2018
CHA University
2014-2018
CHA Gangnam Medical Center
2016
Ulsan College
2013-2014
University of Ulsan
2013-2014
Limited data is available on the prevalence and risk factors of acute chronic urticaria in children. Our purpose was to determine identify Korean children.This population-based study examined 4,076 children (age 4 13 years) who were enrolled 2015 prospective Seongnam Atopy Project (SAP 2015) Korea. The parents completed an questionnaire that included questions regarding duration, severity, triggering urticaria. Blood sampling (n=464) performed measure vitamin D, total eosinophil count (TEC),...
The occurrence of numerous cases interstitial lung disease in children (chILD) every spring Korea starting 2006 raised suspicion about a causal relationship with the use humidifier disinfectants (HDs). aim this study was to evaluate association between HD and risk chILD.This retrospective, 1∶3 matched case-control consisted 16 chILD that had developed 2010 2011. three groups parallel controls (patients acute lobar pneumonia, asthma, healthy children) were by age, gender, index date....
Microbial colonization of the infant gut is unstable and shows a wide range diversity between individuals. Gut microbiota play an important role in development immune system, imbalance these organisms can affect health, including increased risk allergic diseases. young infants affected by delivery mode at birth consequent alterations early life We investigated effects on temporal dynamics healthy Korean infants. Fecal samples were collected 1-3 days, 1 month, 6 months after six Microbiota...
Atopic dermatitis (AD) is characterized by a heterogeneous clinical spectrum, and some forms of AD are associated with the initial steps allergic march. The aims this study were to determine phenotypes in school-age children investigate their associations march each cluster.We included 242 (6-8 years) current from Children's HEalth Environmental Research study, 4-year prospective follow-up 2-year survey intervals. Latent class analysis was used. Serum IL-13 thymic stromal lymphopoietin...
Purpose: Allergic rhinitis (AR) is a common chronic disease.Many factors could affect the development of AR.We investigated early-life factors, such as delivery mode, feeding method, and use antibiotics during infancy, which AR.In addition, how interactions between these innate gene polymorphisms influence AR was investigated.Methods: A cross-sectional study 1,828 children aged 9-12 years conducted.Three were assessed by questionnaire.Skin prick tests done.Polymorphisms TLR4 (rs1927911) CD14...
Treatment guidelines for asthma have been established based on severity; there are limitations in the identification of underlying pathophysiology and prediction prognosis heterogeneous phenotypes asthma. Although complex interactions between environmental genetic factors affect development progression asthma, studies considering limited. This study aimed to identify using latent class analysis including school-age children.We included 235 children (6-8 years) with parent-reported,...
Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of epidermis and formation skin barrier. Recent studies showed atopic dermatitis (AD) associates closely with loss-of-function mutations in FLG gene. Asian European populations differ frequencies mutations. Several mutations, including 3321delA, E2422X, K4671X, S2554X, R501X, occur frequently Chinese Japanese populations. The association between three null AD Korean children was investigated. 1,430 (aged 0-18...
Purpose:The nature of allergic rhinitis (AR) in preschool aged children remains incompletely characterized.This study aimed to investigate the prevalence AR and its associated risk factors preschool-aged assess clinical utility fractional exhaled nitric oxide (FeNO).Methods: This general population-based, cross-sectional survey included 933 (3-to 7-year-old) from Korea.Current was defined as having nasal symptoms within last 12 months physician-diagnosed AR.Results: The current 17.0%...
Purpose: Measurement of the fractional concentration exhaled nitric oxide (FeNO) is a quantitative, noninvasive, simple, safe method assessing airway inflammation.While FeNO measurement has been standardized, reference values for elementary school children are scarce.The aim this study was to establish in children.Methods: measured at 6-12 years age Seoul, Korea, following American Thoracic Society guidelines and using chemiluminescence analyzer (NIOX Exhaled Nitric Oxide Monitoring System,...
Background Relationship between recurrent wheeze and airway function inflammation in preschool children is not fully known. Objective To investigate the relationship inflammation, lung function, hyper-reactivity (AHR) atopy children. Design Observational study, comparing forced expiratory volume 1 s (FEV ), vital capacity (FVC) mid-forced flow (FEF 25%–75% dose–response slope (DRS), exhaled nitric oxide (eNO) atopic sensitisation with those without. Setting Population-based, cross-sectional...
Purpose: Although many previous studies have attempted to identify differences between atopic asthma (AA) and non-atopic (NAA), they mainly focused on the difference of each variable lung function airway inflammation.The aim this study was evaluate relationships function, bronchial hyperresponsiveness (BHR), exhaled nitric oxide (eNO) levels in children with AA NAA.Methods: One hundred thirty six asthmatic aged 5-15 years 40 normal controls were recruited.Asthma cases classified as (n=100)...
Asthma is characterized by airway inflammation, and bronchial airways are particularly susceptible to oxidant-induced tissue damage. To investigate the effect of dietary antioxidant intake environmental tobacco smoke (ETS) on risk childhood asthma according genotypes diseases. This cross-sectional study included 1124 elementary school children aged 7–12 years old. symptoms smoking history were measured using International Study Allergies in Childhood (ISAAC) questionnaire. Intake vitamin A...
A novel rice (Oryza sativa L.) gene, homologous to Arabidopsis pathogenesis-related NDR1 was cloned from cDNA library prepared 30 min Magnaporthe grisea -treated seedling leaves, and named as OsNDR1. OsNDR1 encoded a 220-aminoacid polypeptide highly similar the AtNDR1 protein. is plasma membrane (PM)-localized protein, presumes through sequence analysis protein localization experiment. Overexpression of promotes expression PBZ1 that essential for activation defense/stressrelated gene. The...
Results: The sensitization rates to Tree pollen mixture I and II were increased as 5.0%, 6.8% in 2000, 8.5%, 9.8% 2005, 14.8%, 17.3% 2010, respectively (trend P < 0.001, respectively). And the D. pteronyssinus cat dander dog changed 55%, 4.8%, 4.8% 62.2%, 11.9%, 28% 63.1%, 12.7%, 16.7% respectively. distribution of sensitized pollens was oak (12.8%), beech (12.4%), pine (10.3%), birch (10%), hazel (9.6%), alder (8%), elder (6.9%), elm (5.4%) study 2010. When allergen/histamine ratio...
Background Allergic rhinitis (AR) is often accompanied by multiple ocular symptoms. This study aimed to evaluate the prevalence of symptoms and impact on quality life in patients with AR. Methods One thousand one hundred seventy-four AR were enrolled from 24 centers Korea. They classified into four groups according Rhinitis Its Impact Asthma (ARIA) guideline also perennial (PAR) seasonal groups. All asked complete questionnaire regarding presence symptoms, such as eye itching, watery eyes,...
The risk of asthma has been increasing in parallel with use acetaminophen, which is a potential source oxidative stress. Toll-like receptor 4 (TLR4) plays critical role not only innate immunity, but also mediating reactive oxygen species induced inflammation. Therefore, we investigated associations between acetaminophen usage and TLR4 polymorphism on bronchial hyperresponsiveness (BHR). number 2,428 elementary school children Seoul Jeongeup cities was recruited. Subjects who used family...
Objective: Bronchodilator responses (BDRs) from impulse oscillometry (IOS) are not interchangeable with those spirometry. We aimed to identify the characteristics of children small airway hyperresponsiveness and determine whether BDR IOS provides an important supplement Methods: The records 592 asthma or suspected who underwent spirometric oscillometric BDRs were retrospectively reviewed. Oscillometric was defined as positive when relative absolute changes Rrs5 Xrs5 beyond two standard...
Objective: Fractional concentration of exhaled nitric oxide (FeNO) is a known marker airway inflammation. The aims this study were to evaluate FeNO, impulse oscillometry (IOS), and spirometry in preschool children investigate their relationship with wheeze hyperresponsiveness (AHR). Methods: We performed population-based, cross-sectional 561 aged 5–6 years. A total 544 completed modified International Study Asthma Allergies Childhood (ISAAC) questionnaire eligible for the study. measured...