A5101781104- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Probiotics and Fermented Foods
- Air Quality and Health Impacts
- Exercise and Physiological Responses
- Biochemical Analysis and Sensing Techniques
- IL-33, ST2, and ILC Pathways
- Insect and Pesticide Research
- Immune Response and Inflammation
- Pesticide Residue Analysis and Safety
- Antimicrobial agents and applications
- Neonatal Respiratory Health Research
- Food Allergy and Anaphylaxis Research
- Occupational exposure and asthma
- Health, Environment, Cognitive Aging
- Lysosomal Storage Disorders Research
- Agricultural Practices and Plant Genetics
- Noise Effects and Management
- Nonmelanoma Skin Cancer Studies
- Respiratory viral infections research
- Occupational and environmental lung diseases
- Climate Change and Health Impacts
University of Ulsan
2015-2025
Ulsan College
2014-2025
Asan Medical Center
2013-2024
Samsung Medical Center
2024
Sungkyunkwan University
2024
Keimyung University
2021
Hanyang University
2019-2021
Ajou University
2014-2019
Dankook University
2019
Seoul National University Hospital
2019
<h3>Introduction:</h3> New approaches to electronic cigarettes (e-cigarettes) as a form of nicotine replacement therapy (NRT) may reduce the rates tobacco-related disease and mortality. Therefore, we investigated effect e-cigarettes on smoking cessation compared with gum. <h3>Methods:</h3> A total 150 subjects were randomly assigned 2 groups each was allocated 12-week supply either or The continuous abstinence rate, 7-day point prevalence abstinence, reduction rate amount, tolerability...
Abstract Background Ruminococcus gnavus ( R . ) are mucin‐degrading gut bacteria that play a key role in the early colonization of by serving as endogenous sources nutrients. They can also influence immune development. We had previously reported lower abundance infants with atopic dermatitis (AD) compared healthy subjects. However, underlying mechanisms remain unclear. In this study, we investigated effect orally administered on antibiotic treatment‐induced dysbiosis (and mechanism) mouse...
Purpose: Alterations in the intestinal microbiota early life affects development of atopic dermatitis (AD) humans.This study aimed to further investigate effects gut dysbiosis an ovalbumin (OVA)-induced mouse model AD.Methods: The AD was developed by serial OVA sensitization and mice were treated with antibiotic cocktail their drinking water for 2 weeks before primary sensitization.Probiotics (Lactobacillus rhamnosus, 1 × 10 9 CFU) or 100 µL fresh fecal supernatant orally administered daily...
Mechanisms underlying persistent food allergy (FA) are not well elucidated. The intestinal mucosa is the primary exposure route of allergens. However, no study has examined metabolites associated with FA persistence. goal this was to investigate and microbiomes in early life that aid determining development persistence FA.We identified metabolomic alterations stool infants according by mass spectrometry-based untargeted metabolome profiling. targeted analysis bile acid microbiome performed....
Purpose: Interleukin (IL)-17 variants and perturbations in the gut microbiota may influence development of atopic dermatitis (AD).However, unifying principles for host microbe interaction remains unclear.We sought to investigate whether IL-17 affect AD infancy.Methods: Composition was analyzed fecal samples from 99 normal healthy 61 infants at 6 months age.The associations between total immunoglobulin E (IgE), scoring (SCORAD), short-chain fatty acids, transcriptome functional profile...
<title>Abstract</title> Prenatal environmental exposures may influence the development of atopic dermatitis (AD), yet underlying mechanisms remain poorly understood. In this study, we conducted an epidemiological analysis 986 children, revealing that first-trimester PM<sub>2.5</sub> exposure significantly increases AD risk at age three. Integrated epigenomic and transcriptomic profiling 48 placentae identified PM<sub>2.5</sub>-associated hypomethylation driving FCER1G overexpression,...
Filaggrin (FLG) is a key protein that facilitates the terminal differentiation of epidermis and formation skin barrier. Recent studies showed atopic dermatitis (AD) associates closely with loss-of-function mutations in FLG gene. Asian European populations differ frequencies mutations. Several mutations, including 3321delA, E2422X, K4671X, S2554X, R501X, occur frequently Chinese Japanese populations. The association between three null AD Korean children was investigated. 1,430 (aged 0-18...
Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate mechanism on inflammation mediated by PAR2.Human lung epithelial cells (A549 cells) were used for vitro, and German cockroach extract (GCE)-induced mouse model was developed vivo studies.In A549 cells, levels of reactive oxygen species (ROS) thymic stromal lymphopoietin (TSLP) significantly increased GCE treatment, but suppressed PAR2-antagonist (PAR2-ant) or...
Abstract Exposure to chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) has been associated with allergic contact dermatitis and occupational asthma. Despite this association however, no study investigated the effects of CMIT/MIT exposure on development atopic (AD). This was conducted investigate influence epicutaneous AD in a mouse model underlying biological mechanisms. BALB/C mice were exposed for 3 weeks developed using ovalbumin (OVA) epidermal sensitization. normal...
The complex interplay between environmental and genetic factors plays an important role in the development of asthma. Several studies have yielded conflicting results regarding 2 asthma-related risk factors: antibiotic usage during infancy and/or a history bronchiolitis early life In addition to these factors, we also explored effects Toll-like receptor 4 (TLR4) polymorphism on childhood asthma.This cross-sectional study involved 7,389 middle school students who were from 8 areas Seoul,...
The risk of asthma has been increasing in parallel with use acetaminophen, which is a potential source oxidative stress. Toll-like receptor 4 (TLR4) plays critical role not only innate immunity, but also mediating reactive oxygen species induced inflammation. Therefore, we investigated associations between acetaminophen usage and TLR4 polymorphism on bronchial hyperresponsiveness (BHR). number 2,428 elementary school children Seoul Jeongeup cities was recruited. Subjects who used family...
We investigated the long-term patterns and effects of transfusion on clinical outcome patients undergoing percutaneous coronary intervention (PCI) using a nationwide registry. Five-year all Koreans PCI stent in year 2011 (n = 48,786) was investigated. Primary incidence density transfusion. The association with major adverse event (MACE) consisting all-cause death, revascularization, critically ill cardiovascular status, or stroke assessed after adjusting propensity each patient for 5-year...