A5010182210- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Autoimmune and Inflammatory Disorders Research
- Myasthenia Gravis and Thymoma
- Vasculitis and related conditions
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Neonatal and Maternal Infections
- IgG4-Related and Inflammatory Diseases
- Peripheral Neuropathies and Disorders
- Retinopathy of Prematurity Studies
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Inflammasome and immune disorders
- Probiotics and Fermented Foods
- Atomic and Subatomic Physics Research
- Abdominal Trauma and Injuries
- Infant Development and Preterm Care
- Chronic Obstructive Pulmonary Disease (COPD) Research
Inje University Busan Paik Hospital
2011-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Guangdong Academy of Agricultural Sciences
2022-2024
Affiliated Hospital of Southwest Medical University
2024
Inje University Haeundae Paik Hospital
2013-2024
Inje University Seoul Paik Hospital
2011-2024
Central South University
2012-2022
First Affiliated Hospital of Zhengzhou University
2021-2022
Henan Provincial Center for Disease Control and Prevention
2022
Second Xiangya Hospital of Central South University
2019-2022
To assess the recent epidemiologic features of Kawasaki disease (KD) in South Korea from nationwide survey conducted between 2009 and 2011.We collected data regarding incidence, symptoms, treatment coronary complications associated with acute KD by sending questionnaires to 100 hospitals that have pediatric residency programs received complete responses 73 partial 14 hospitals. A total 13,031 patients were reported 87 (3941 2009, 4635 2010 4455 2011). The male female ratio was 1.44:1, median...
Abstract Background Community–acquired pneumonia (CAP) is one of the leading worldwide causes childhood morbidity and mortality. Its disease burden varies by age etiology time dependent. We aimed to investigate annual seasonal patterns in etiologies pediatric CAP requiring hospitalization. Methods conducted a retrospective study 30,994 children (aged 0–18 years) with between 2010 2015 at 23 nationwide hospitals South Korea. Mycoplasma pneumoniae (MP) was clinically classified as...
Background: To explore the effect of albiflorin (AL) on streptozotocin (STZ)-induced Alzheimer's disease (AD) in rats. Methods: A mouse model diabetic encephalopathy was established by intraperitoneal injection 1%STZ. Step down test and water maze were used to cognitive function Congo Red Staining detect distribution Aβ plaques hippocampus Cytokine levels serum measured using ELISA. Serum insulin, oral glucose tolerance (OGTT), superoxide dismutase (SOD) activity malondialdehyde (MDA)...
Approximately 10-15% of children with Kawasaki disease (KD) do not respond to initial intravenous immunoglobulin (IVIG) and have higher risk for coronary artery lesion (CAL). The aim this study was identify predictive factors from laboratory findings in patients who IVIG treatment develop CAL KD.We retrospectively collected nationwide multicenter data the Korean Society Disease included 5,151 KD between 2012 2014 38 hospitals.Among KD, 524 belonged IVIG-resistant group. group had a...
Purpose Studies have been conducted to identify predictive factors of resistance intravenous immunoglobulin (IVIG) for Kawasaki disease (KD). However, the results are conflicting. This study aimed laboratory high-dose IVIG KD by performing meta-analysis available studies using statistical techniques. Methods All relevant scientific publications from 2006 2014 were identified through PubMed searches. For in English on and resistance, included. A was performed that calculated effect size...
Patients with biliary tract cancer (BTC) were associated poor prognosis and limited therapeutic options after first-line therapy currently. In this study, we sought to evaluate the feasibility tolerability of sintilimab plus anlotinib as second-line treatment for patients advanced BTC. Eligible had histologically confirmed locally unresectable or metastatic BTC failed recruited. The primary endpoint was overall survival (OS). Simultaneously, association between clinical outcomes genomic...
Kawasaki disease (KD) is an acute systemic vasculitis that can potentially cause coronary artery aneurysms in some children. KD occurs approximately 1.5 times more frequently males than females. To identify sex-specific genetic variants are involved pathogenesis children, we performed a sex-stratified genome-wide association study (GWAS), using the Illumina HumanOmni1-Quad BeadChip data (249 cases and 1,000 controls) replication for 34 candidate SNPs independent sample set (671 3,553...
Background and Objectives:This was a multicenter study to evaluate the usefulness of tumor necrosis factor-alpha (TNF-α) blocker infliximab for treatment Korean pediatric patients with refractory Kawasaki disease (KD).Subjects Methods: Data from 16 throughout Korea who were diagnosed KD received collected retrospectively.Results: Complete response therapy cessation fever occurred in 13 patients.C-reactive protein (CRP) concentrations decreased following infusion all 14 whom it measured...
To address the research gap in epidemiology of pediatric respiratory tract infections (RTIs) Luzhou, Southern Sichuan, China, by analyzing pathogens a large cohort from 2018 to 2021, covering pre- and during-COVID-19 periods.
Purpose We conducted a study to determine which factors may be useful as predictive markers in identifying Kawasaki disease (KD) patients with high risk of resistance intravenous immunoglobulin (IVIG) and developing coronary artery lesions (CAL). Methods enrolled 287 acute phase KD at single center. The demographic, clinical laboratory data were collected retrospectively. Results There 34 the IVIG resistant group. group had significantly higher serum N-terminal-pro-brain natriuretic protein...
Background and Objectives:We investigated the status of infliximab use in intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients incidence coronary artery aneurysms (CAAs) according to treatment regimens.Methods: Between March 2010 February 2017, 16 hospitals participated this study.A total 102 (32.3±19.9months, 72 males) who received at any time after first IVIG failure were enrolled.Data retrospectively collected using a questionnaire.Results: Subjects divided into two...
Background Hyper-immunoglobulin E (IgE) syndromes (HIES) are a group of primary immune deficiencies disorders (PID) characterized by elevated serum IgE, eczema, recurrent skin, or respiratory system infections and may also be accompanied some connective tissues skeletal abnormalities. Currently, there is no complete cure targeted treatment for HIES. Omalizumab humanized recombinant monoclonal antibody against reducing the level free inhibiting binding IgE to receptors on surface effector...
This study aimed to generate a Z score calculation model for coronary artery diameter of normal children and adolescents be adopted as the standard method with consensus in clinical practice.
Turner syndrome is well known to be associated with significant cardiovascular abnormalities.This paper studied the incidence of abnormalities in asymptomatic adolescent patients using multidetector computed tomography (MDCT) instead echocardiography.Twenty subjects diagnosed who had no cardiac symptoms were included.Blood pressure and electrocardiography (ECG) was checked.Cardiovascular checked by MDCT.According ECG results, 11 a prolonged QTc interval, 5 posterior fascicular block, 3...
Kawasaki disease (KD) is a systemic vasculitis that mainly affects younger children. Intravenous immunoglobulin (IVIG) resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potential nonresponders and treatment IVIG-resistant patients now controversial. In this review the definition predictors KD current evidence to guide management discussed. Key words: disease, immunoglobulin, Resistance, Predictors, Management