A5071339140- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Autoimmune and Inflammatory Disorders Research
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Vasculitis and related conditions
- Blood Coagulation and Thrombosis Mechanisms
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Hepatitis B Virus Studies
- Streptococcal Infections and Treatments
- Inflammasome and immune disorders
- IgG4-Related and Inflammatory Diseases
- Reproductive System and Pregnancy
- Bacterial Infections and Vaccines
- Ectopic Pregnancy Diagnosis and Management
- Congenital Heart Disease Studies
- Hepatitis Viruses Studies and Epidemiology
- Congenital Diaphragmatic Hernia Studies
Gangneung Asan Hospital
2006-2024
University of Ulsan
2006-2024
Ulsan College
2006-2021
Asan Medical Center
2018
Chung-Ang University Hospital
2018
Kyung Hee University Hospital at Gangdong
2018
Catholic University of Korea
2018
Kawasaki disease (KD) is an acute systemic vasculitis that can potentially cause coronary artery aneurysms in some children. KD occurs approximately 1.5 times more frequently males than females. To identify sex-specific genetic variants are involved pathogenesis children, we performed a sex-stratified genome-wide association study (GWAS), using the Illumina HumanOmni1-Quad BeadChip data (249 cases and 1,000 controls) replication for 34 candidate SNPs independent sample set (671 3,553...
BACKGROUND AND OBJECTIVES Kawasaki disease (KD) is an acute systemic vasculitis that affects the coronary arteries. Abnormal immune reactions are thought to contribute pathogenesis. The effect of immunoglobulin (Ig) isotype (IgG, IgA, IgM, and IgE) on inflammatory data clinical outcomes patients with KD was examined. METHODS Ig levels in 241 were measured during acute, subacute, convalescent, normal phases disease. RESULTS Compared reference values, IgG, IgM significantly higher subacute...
Background and Objectives: Patients with Kawasaki disease (KD) are clinically heterogeneous because its diagnosis is based solely on clinical observation there no definitive biomarkers.We dissected the heterogeneity of KD patients using KDassociated genetic variants.Methods: We performed a association analysis in several subgroups categorized by characteristics KD-associated variants B lymphoid tyrosine kinase (BLK; rs6993775) Fc gamma receptor II (FCGR2A; rs1801274) large number case...
Surgical skill and strategy for the correction of tetralogy Fallot (TOF) have improved resulted in satisfactory outcomes. However, prematurity low birth weight continue to remain risk factors poor We present a case 2,150 g neonate born with TOF, whom palliation was achieved right ventricular outflow tract (RVOT) stenting. Seventy-seven days after procedure, stenosis RVOT below stent identified. At that time his body 4.9 kg total corrective surgery deemed feasible. Eight months following...
Kawasaki disease (KD) is an acute pediatric vasculitis that affects genetically susceptible infants and children. To identify coding variants influence susceptibility to KD, we conducted whole exome sequencing of 159 patients with KD 902 controls, performed a replication study in independent 586 cases 732 controls. We identified five rare genes (FCRLA, PTGER4, IL17F, CARD11, SIGLEC10) associated (odds ratio [OR], 1.18–4.41; p = 0.0027–0.031). also association analysis 26 coronary artery...
Kawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD from 6 months to 5 years age, the unusual in those younger than older age. We tried identify genetic variants specifically associated with patients or performed age-stratified genome-wide association study using Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) a replication (1,360 3,553 Korean population. Among 26 candidate single nucleotide...
Kawasaki disease (KD) is an acute vasculitis that primarily affects children under age 5 years. Approximately 20-25% of untreated with KD and 3-5% those treated intravenous immunoglobulin therapy develop coronary artery aneurysms (CAAs). The prevalence CAAs much higher in male than female patients KD, but the underlying factors contributing to susceptibility remain unclear. This study aimed identify sex-specific loci associated patients.
Purpose:To evaluate the immunogenicity of hepatitis B vaccine among very low birth weight infants(VLBWI) who were vaccinated at 0, 1, 6 months chronological age and to determine factors associated with antibody formations. Methods:A total 243 VLBWI admitted Seoul Gangneung Asan Medical Center neonatal intensive care units from 1997 2004 included. Of 243, 13 infants born HBs Ag positive mother. All given DNA recombinant age. Infants mothers received immunoglobulin a 4 doses vaccinations. An...
Purpose : This study aimed to determine the variation in parameters according cardiac cycle length (CL; time interval between QRS peaks on ECG) children by using conventional pulsed Doppler and tissue imaging echocardiography. Methods Eighteen with an anatomically normal heart were enrolled for study. All examined echocardiography at Gangneung Asan hospital July 2006 June 2007. We measured CLs, mitral inflow velocities (E,A) (TDI) (s', e', a') from apical 4-chamber view. The TDI lateral...
Purpose:The object of this study was to determine the difference between two methods for myocardial performance index(MPI) in children, using conventional and pulsed Doppler echocardiography. Methods:A total 27 children with anatomically normal hearts were enrolled study. all examined by echocardiography at Gangneung Asan Hospital December, 2005 February, 2006. First, we measured time interval(a1) mitral inflows from apical 4-chamber view, ejection time(ET1) 5-chamber view. And then,...