A5063044645- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Indoor Air Quality and Microbial Exposure
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- Immunodeficiency and Autoimmune Disorders
- Virology and Viral Diseases
- Inhalation and Respiratory Drug Delivery
- Microbial infections and disease research
- Health and Wellbeing Research
- Blood groups and transfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Vitamin D Research Studies
- Health Literacy and Information Accessibility
- Sleep and related disorders
- Intestinal Malrotation and Obstruction Disorders
- Psychosocial Factors Impacting Youth
- Food Allergy and Anaphylaxis Research
- Influenza Virus Research Studies
Korea University Medical Center
2010-2023
Korea University
2010-2021
Ministry of Environment
2014
Children's Hospital of Pittsburgh
1996
Rationale: Beginning in 2006, epidemics of a fatal lung injury unknown cause children were observed Korea every spring. A recent study demonstrated that this type children's interstitial disease (chILD) is associated with humidifier disinfectant use.Objectives: To determine the clinical characteristics chILD and to assess whether nationwide suspension sales autumn 2011 affected its incidence.Methods: The suspected cases between 2006 determined by retrospective study. potential causal...
Epidemiological Change of Atopic Dermatitis
The aim of this study was to investigate the possible adverse effects Asian dust events on respiratory health in asthmatic children. Fifty-two children with mild asthma were studied for eight consecutive weeks spring 2004 (March 8 May 2). During period, five days identified; we included a lag period two following each events. Subjects recorded their symptom diaries and peak expiratory flow (PEF) twice daily during period; they underwent methacholine bronchial challenge tests. subjects...
This article was intended to introduce the Korean Surveillance System for Childhood Asthma (KSSCA) and also determine factors that increase risk development of asthma allergic diseases in preschool children Korea based on study results.The KSSCA pilot a web-based, cross-sectional survey sampled 1002 parents with biological child aged 2-6 years visited website participated survey. consisted questionnaire designed measure history prevalence diseases, characteristics dwelling, lifestyle,...
Although the role of eosinophils in eosinophilic gastroenteritis (EGE) is not fully understood, they are believed to be a principal effector cell. Previous studies have demonstrated that eotaxin and its specific receptor, cysteine-cysteine chemokine receptor-3 (CCR3), play central eosinophil trafficking into gastrointestinal (GI) tract. Thus, we examined targeting CCR3 as potential therapeutic intervention for EGE mouse model. Eight- 10-week-old BALB/c mice were intraperitoneally sensitized...
The prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) has increased worldwide. aim this study was to estimate the proportion MRMP in a tertiary hospital Korea, and find potential laboratory markers that could be used predict efficacy macrolides children with pneumonia.A total 95 patients M. pneumonia were enrolled study. Detection based on results specific point mutations domain V 23S rRNA gene. medical records these reviewed retrospectively clinical course data compared.The...
Exposure to heavy metals such as lead, cadmium, and mercury poses serious health risks pregnant women because of their high toxicity. In this study, we investigated the associations metal exposure with birth outcomes Korean infants. Data 5,215 between 2015 2019 were analyzed. This study was part Children's Environmental Health (Ko-CHENS) study. Linear regression logistic analyses used examine effects concentrations on weight, small for gestational age, large age after adjusting maternal...
Purpose:The role of PM10 in the development allergic diseases remains controversial among epidemiological studies, partly due to inability control for spatial variations large-scale risk factors.This study aims investigate correspondence between level and at sub-district Seoul, Korea, order evaluate whether impact is observable spatially varies across subdistricts.Methods: measurements 25 monitoring stations city were interpolated 424 sub-districts where annual inpatient outpatient count...
The aim of this study was to investigate the change in macrolide resistance rate pediatric Mycoplasma pneumoniae pneumonia and evaluate influence macrolide-resistant M. (MRMP) on clinical course disease, by comparing 2 recent, consecutive epidemics Korea.A total 250 patients with admitted a single tertiary hospital were enrolled study. Detection MRMP based specific point mutations domain V 23S rRNA gene. medical records reviewed retrospectively, courses laboratory data compared.The 51.1%...
Agenerally accepted consensus of end-of-life (EOL) care decision-making did not appear in Korean medical society until the year 2009. To enhance physician's ethical perception EOL care, guidelines to withdrawing life-sustaining therapies endorsed by Medical Association, Academy Science, and Hospital were published on October 13, In this article, characteristics issues with are presented improve understanding physicians who interact patients. According guidelines, should identify, document,...
Abstract Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was evaluate cytokine secretion with acute and wheeze. We studied 58 patients (12 wheeze, Group 1; 46 without 2) 36 non‐mycoplasma (Group 3). Serum levels interleukin (IL)‐4, IL‐5, interferon (IFN)‐γ, vascular endothelial growth factor (VEGF) were measured using an enzyme‐linked immunosorbent assay kits. mean ± SD IL‐5 level 1 97.1 73.0 pg/ml, which...
ship with poverty and substandard housing conditions, [6][7][8] but the relationship between income AD/AR has not been clearly demonstrated.Although some studies have reported a positive association prevalence of AD, [9][10][11] others indicate that AD is greater for low-income families 12 or significantly related to income. 13,14he impact economic status AR also unclear; elevated among high-income households, 15,16 argue does affect prevalence. 17-19However, few evaluated indoor risk...
We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization asthmatic children. A total 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, measurement blood eosinophil count, serum IgE, cationic protein (ECP). also sensitization to five classes aeroallergens (house dust mites, animal danders, pollens, molds, cockroach) using skin prick testing....
The performance of the SD Bioline rapid antigen test kit for influenza virus detection was evaluated with 295 respiratory specimens during season. overall sensitivity and specificity were 61.9% 96.8% A 54.5% 100% B antigen, respectively. results consistent peak activities.
Abstract Aim: To determine whether nasopharyngeal aspirates (NPAs) cytokine response is different according to the causative viruses in children with lower respiratory tract infections (LRTI). Methods: NPAs from 277 LRTI caused by virus were evaluated. Based on proven viral agents, patients divided into four groups. Levels of IL‐4, IL‐5 and IFN‐γ determined ELISA. Results: Patients influenza infection demonstrated significantly IL‐4 levels than those other three syncytial (RSV) showed an...
This study was conducted to investigate the immune responses of children with moderate and severe novel influenza A virus (H1N1) pneumonia, compare their clinical immunological findings those control subjects.Thirty-two admitted patients H1N1 pneumonia were enrolled in study. The profiles, humoral cell-mediated 16 who pediatric intensive care unit (severe group), general ward (moderate group) 13 subjects (control measured.Total lymphocyte counts significantly lower than group (P=0.02)....
Recently, epidemiologic studies have shown that the lack of serum vitamin D levels may be associated with high asthma prevalence, but its effect is still controversial, depending on season, area, and food consumption. We aimed to examine association prevalence pediatric in Korea. A total 80 children (50 asthmatic 30 healthy controls) aged 6-14 years were participated this study. Serum measured compared between two groups. Moreover, relationship results pulmonary function test environmental...
The purpose of this study was to investigate the association between asthma and invasive pneumococcal disease (IPD) in Korea. A retrospective population-based cohort conducted using Korean Health Insurance Review Assessment database 2010-2011. subjects included 935,106 (2010) 952,295 (2011), whom 398 428 (2011) patients with IPD were identified. There significant difference prevalence without (0.07% vs. 0.02% 2010 0.08% 0.01% 2011; P<0.001). After adjusting for age gender, showed over a...
Atopic dermatitis (AD) is an inflammatory, chronically relapsing, puritic skin disorder. These syndromes result from multifactorial inheritance, with interaction between genetic and environmental factors. In particular, the macrophage-derived chemokine CCL22 directly implicated in inflammatory reactions its levels are significantly elevated serum correlated disease severity AD. We tested suppression of gene by microRNA (miRNA) observed effects mice inflammation similar to used Salmonella as...
To identify the association between residential environmental risk factors and prevalence of childhood asthma, authors surveyed 1819 elementary school students, air pollution in metropolitan (Seongbuk), semirural (Andong) areas. Although there was no significant difference self-reported asthma (SA) 2 geographic areas (12.8% vs 13.6%), physician-diagnosed (PDA) Andong (15.0%) significantly higher than that Seongbuk (6.8%). After adjusting for confounding factors, logistic regression suggested...