A5048582930- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Gut microbiota and health
- Antimicrobial agents and applications
- Tracheal and airway disorders
- Noise Effects and Management
- Respiratory viral infections research
- Climate Change and Health Impacts
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Breastfeeding Practices and Influences
- Contact Dermatitis and Allergies
- Stress Responses and Cortisol
- Infant Health and Development
- Probiotics and Fermented Foods
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Ulsan College
2016-2025
National Taiwan University
2025
Lee University
2024
Yonsei University
2004-2024
Soonchunhyang University
2003-2024
Korea Basic Science Institute
2024
Korea Institute of Oriental Medicine
2024
Hallym University
2002-2024
Abstract Asthma is the most common chronic lower respiratory disease in childhood throughout world. Several guidelines and/or consensus documents are available to support medical decisions on pediatric asthma. Although there no doubt that use of systematic approaches for management can considerably improve outcomes, dissemination and implementation these still major challenges. Consequently, I nternational C ollaboration Asthma, Allergy Immunology (i CAALL ), recently formed by EAACI , AAAAI...
Institutional review board approval and written informed consent were obtained. Although xenon (Xe) ventilation CT has been introduced as a potential method with which to depict regional ventilation, quantification of Xe enhancement limited by the variability lung attenuation caused different volumes between scans. The purpose this study was assess feasibility dual-energy technique. Dual-energy performed in 12 subjects after inhalation. With use technique, component could be extracted...
Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10−8) in GWAS were further genotyped an independent samples (818 cases 1,032 controls) Korean (835 421 controls). SNP rs987870, located between HLA-DPA1 HLA-DPB1, was consistently associated 3 populations (Pcombined = 2.3×10−10, odds...
Rationale: Beginning in 2006, epidemics of a fatal lung injury unknown cause children were observed Korea every spring. A recent study demonstrated that this type children's interstitial disease (chILD) is associated with humidifier disinfectant use.Objectives: To determine the clinical characteristics chILD and to assess whether nationwide suspension sales autumn 2011 affected its incidence.Methods: The suspected cases between 2006 determined by retrospective study. potential causal...
Probiotic bacteria can induce immune regulation or tolerance in allergic diseases. The underlying mechanisms have been recently investigated, but are still unclear. aim of this study was to evaluate the protective effects probiotic Lactobacillus rhamnosus (Lcr35) a mouse model asthma and identify its mechanism action. Lcr35 administered daily by oral route at dosage 1×10(9) CFU/mouse BALB/c mice for 7 days before first sensitization. Clinical parameters regulatory T (Treg) cells were...
Purpose: Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups.We aimed to identify by Korean children.Methods: We performed a retrospective review of medical records for children diagnosed with between 2009 and 2013 23 secondary or tertiary hospitals South Korea.Results: A total 991 cases (mean age=5.89±5.24)were reported, 63.9% involving patients younger than 6 years 66% male children.Food was the...
Purpose:The roles of gut microbiota on the natural course atopic dermatitis (AD) are not yet fully understood.We investigated whether composition and function short-chain fatty acids (SCFAs) at 6 months age could affect AD up to 24 in early childhood.Methods: Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient 26 persistent subjects Cohort for Childhood Origin Asthma Allergic Diseases (COCOA) birth cohort.The functional profile...
Summary Objectives The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires have shown that the prevalence childhood asthma is increasing worldwide. Although Asian countries used to lower rates allergic disease than Western countries, this several countries. To determine whether changing Korean adolescents, we compared findings from nationwide cross‐sectional surveys 1995 2000 on populations middle‐school children using version ISAAC questionnaire. Methods We...
Humidifier disinfectant lung injury is an acute disease attributed to recurrent inhalation of certain aerosols emitted from room humidifiers. An outbreak this toxic occurred in South Korea 1995 until all humidifier products were recalled the consumer market by government 2011.A nationwide study was conducted ascertain and classify potential cases assess dose-response relationships.By several mechanisms, clinicians general public invited report suspected health officials Korea. A committee...
Abstract The gasdermin A (GSDMA) and B (GSDMB) genes are located at 17q21.2. GSDM family have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma several populations. We investigated association of GSDMA variants Korean children, to assess effect these on intermediate phenotypes asthma. Asthmatic (n = 778) normal 522) children were enrolled genotypes determined using PCR‐RFLP. Asthma susceptibility was GG (rs7212938) TT...
The occurrence of numerous cases interstitial lung disease in children (chILD) every spring Korea starting 2006 raised suspicion about a causal relationship with the use humidifier disinfectants (HDs). aim this study was to evaluate association between HD and risk chILD.This retrospective, 1∶3 matched case-control consisted 16 chILD that had developed 2010 2011. three groups parallel controls (patients acute lobar pneumonia, asthma, healthy children) were by age, gender, index date....
Background Although cesarean delivery and prenatal exposure to antibiotics are likely affect the gut microbiome in infancy, their effect on development of atopic dermatitis (AD) infancy is unclear. The influence individual genotypes these relationships also To evaluate with a prospective birth cohort study whether section, antibiotics, susceptible act additively promote AD infancy. Methods Cohort for Childhood Asthma Allergic Diseases (COCOA) was selected from general Korean population. A...
Microbes in the airway have been shown to be associated with pathogenesis of asthma. The upper microbiome influences dysbiosis lower microbiome. However, date, influence for adult and elderly asthma has not fully elucidated. Here, metagenome young adults was analyzed identify their association asthma.Nasopharyngeal swabs were collected from patients non-asthmatic subjects. compositions functional genes by high-throughput sequencing.The composition microbiota differed between elderly, it...
Abstract Background Ruminococcus gnavus ( R . ) are mucin‐degrading gut bacteria that play a key role in the early colonization of by serving as endogenous sources nutrients. They can also influence immune development. We had previously reported lower abundance infants with atopic dermatitis (AD) compared healthy subjects. However, underlying mechanisms remain unclear. In this study, we investigated effect orally administered on antibiotic treatment‐induced dysbiosis (and mechanism) mouse...
The gut microbiome influences the development of allergic diseases during early childhood. However, there is a lack comprehensive understanding microbiome-host crosstalk. Here, we analyzed influence dynamics in childhood on atopic dermatitis (AD) and potential interactions between host that control this homeostasis. We 346 fecal samples (6–36 months; 112 non-AD, 110 mild AD, 124 moderate to severe AD) from Longitudinal Cohort for Childhood Origin Asthma Allergic Disease birth cohort. were...
Abstract Food allergy (FA) is a widespread issue, affecting as many 10% of the population. Over past two to three decades, prevalence FA has been on rise, particularly in industrialized and westernized countries. complex, multifactorial disease mediated by type 2 immune responses involving environmental genetic factors. However, precise mechanisms remain inadequately understood. Metabolomics potential identify endotypes, which could beneficially promote personalized prevention treatment. A...
Summary Background A disintegrin and metalloprotease 33 (ADAM33) is expressed in the lung by fibroblasts bronchial smooth muscle cells. Given its structure cellular provenance, ADAM33 may be associated with airway remodelling hyper‐responsiveness. Single nucleotide polymorphisms (SNPs) haplotypes of gene have previously been asthma susceptibility Caucasian population. Objective Methods To assess whether genetic variants are related to a Korean population, we conducted an association study...
To review our experience with spiral and cine CT imaging for the diagnosis of foreign body aspiration.Fifty-one consecutive pediatric patients suspected aspirating radiolucent FBs underwent chest radiography a 3-dimensional scan 12 also undergoing within 24 hours before rigid bronchoscopy. Bronchoscopic results were compared.Rigid bronchoscopy showed that present in main bronchus or intermedius 42 patients. Spiral scans localized airway these same In remaining nine without FBs, six...